Chapter 3
Shape-memory Polymers for Tissue Engineering Applications
Fangyuan Zheng,
Ane García-García,
Isabel Moreno-Benítez,
Leire Ruiz-Rubio,
Leyre Pérez-Álvarez,
José L. Vilas-Vilela,
Fangyuan Zheng
Basque Centre for Materials, Applications and Nanostructures (BCMaterials), Sarriena no number, Leioa, 48940 Spain
Search for more papers by this authorAne García-García
Basque Centre for Materials, Applications and Nanostructures (BCMaterials), Sarriena no number, Leioa, 48940 Spain
University of Basque Country, Macromolecular Chemistry Group (LABQUIMAC), Faculty of Science and Technology, Department of Physical Chemistry, Sarriena no number, Leioa, 48940 Spain
Search for more papers by this authorIsabel Moreno-Benítez
Basque Centre for Materials, Applications and Nanostructures (BCMaterials), Sarriena no number, Leioa, 48940 Spain
Search for more papers by this authorLeire Ruiz-Rubio
Basque Centre for Materials, Applications and Nanostructures (BCMaterials), Sarriena no number, Leioa, 48940 Spain
University of Basque Country, Macromolecular Chemistry Group (LABQUIMAC), Faculty of Science and Technology, Department of Physical Chemistry, Sarriena no number, Leioa, 48940 Spain
Search for more papers by this authorLeyre Pérez-Álvarez
Basque Centre for Materials, Applications and Nanostructures (BCMaterials), Sarriena no number, Leioa, 48940 Spain
University of Basque Country, Macromolecular Chemistry Group (LABQUIMAC), Faculty of Science and Technology, Department of Physical Chemistry, Sarriena no number, Leioa, 48940 Spain
Search for more papers by this authorJosé L. Vilas-Vilela
Basque Centre for Materials, Applications and Nanostructures (BCMaterials), Sarriena no number, Leioa, 48940 Spain
University of Basque Country, Macromolecular Chemistry Group (LABQUIMAC), Faculty of Science and Technology, Department of Physical Chemistry, Sarriena no number, Leioa, 48940 Spain
Search for more papers by this authorFangyuan Zheng,
Ane García-García,
Isabel Moreno-Benítez,
Leire Ruiz-Rubio,
Leyre Pérez-Álvarez,
José L. Vilas-Vilela,
Fangyuan Zheng
Basque Centre for Materials, Applications and Nanostructures (BCMaterials), Sarriena no number, Leioa, 48940 Spain
Search for more papers by this authorAne García-García
Basque Centre for Materials, Applications and Nanostructures (BCMaterials), Sarriena no number, Leioa, 48940 Spain
University of Basque Country, Macromolecular Chemistry Group (LABQUIMAC), Faculty of Science and Technology, Department of Physical Chemistry, Sarriena no number, Leioa, 48940 Spain
Search for more papers by this authorIsabel Moreno-Benítez
Basque Centre for Materials, Applications and Nanostructures (BCMaterials), Sarriena no number, Leioa, 48940 Spain
Search for more papers by this authorLeire Ruiz-Rubio
Basque Centre for Materials, Applications and Nanostructures (BCMaterials), Sarriena no number, Leioa, 48940 Spain
University of Basque Country, Macromolecular Chemistry Group (LABQUIMAC), Faculty of Science and Technology, Department of Physical Chemistry, Sarriena no number, Leioa, 48940 Spain
Search for more papers by this authorLeyre Pérez-Álvarez
Basque Centre for Materials, Applications and Nanostructures (BCMaterials), Sarriena no number, Leioa, 48940 Spain
University of Basque Country, Macromolecular Chemistry Group (LABQUIMAC), Faculty of Science and Technology, Department of Physical Chemistry, Sarriena no number, Leioa, 48940 Spain
Search for more papers by this authorJosé L. Vilas-Vilela
Basque Centre for Materials, Applications and Nanostructures (BCMaterials), Sarriena no number, Leioa, 48940 Spain
University of Basque Country, Macromolecular Chemistry Group (LABQUIMAC), Faculty of Science and Technology, Department of Physical Chemistry, Sarriena no number, Leioa, 48940 Spain
Search for more papers by this authorBook Editor(s):Senentxu Lanceros-Méndez,
Clarisse Ribeiro,
Unai Silván,
Senentxu Lanceros-Méndez
Basque Center for Materials Applications, UPV/EHU Science Park, Leioa, 48940 Spain
Search for more papers by this authorClarisse Ribeiro
Universidade do Minho, Braga, 4710-057 Portugal
Search for more papers by this authorUnai Silván
Basque Center Mater, Appl, Nanostruc, UPV/EHU Science Park, Leioa, 48940 Spain
Search for more papers by this authorFirst published: 22 November 2024
Summary
Growing interest on tissue engineering has driven the fast advancement of shape-memory polymers. These materials are able to recover a programmed shape when an external stimulus is applied. This unique functionality has been used to promote tissue defect filling and stimulate cell differentiation and new tissue generation. In this review, we describe the structural specifications that explain the shape recovery in the diverse range of shape-memory polymers, as well as the critical requirements that must been considered in their design to their successful integration and in vivo performance. Moreover, this chapter reviews recent investigations related to tissue engineering applications of shape-memory homopolymers/copolymers, composites, and hydrogels. We reviewed the physicochemical properties of SMPs with a huge variety of structures and trigger stimuli, and their contributions to the tissue regeneration and formation in cellular and in vivo experiments devoted to the repair of different tissue types. New perspectives in the field that allow the effective translation of these materials to the clinic are also highlighted.
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