Chapter 99
Immunoglobulin G Glycosylation and Galactosyltransferase Changes in Rheumatoid Arthritis
John S. Axford,
John S. Axford
Search for more papers by this authorJohn S. Axford,
John S. Axford
Search for more papers by this authorProf. Dr. Beat Ernst,
Prof. Dr. Gerald W. Hart,
Prof. Dr. Pierre Sinaý,
Prof. Dr. Beat Ernst
Institut für Molekulare Pharmazie, Universität Basel, Klingenbergstrasse 50, 4051 Basel, Switzerland
Search for more papers by this authorProf. Dr. Gerald W. Hart
Dept. of Biological Chemistry, Johns Hopkins University School of Medicine, 725 N. Wolf St. Rm., 401 Hunterian Baltimore, MD 21205-2185, USA
Search for more papers by this authorProf. Dr. Pierre Sinaý
Dept. de Chimie, URA 1686, Ecole Normale Supérieure, 24 rue Lhomond, 75231 Paris Cedex 05, France
Search for more papers by this authorBook Author(s):Prof. Dr. Beat Ernst,
Prof. Dr. Gerald W. Hart,
Prof. Dr. Pierre Sinaý,
Prof. Dr. Beat Ernst
Institut für Molekulare Pharmazie, Universität Basel, Klingenbergstrasse 50, 4051 Basel, Switzerland
Search for more papers by this authorProf. Dr. Gerald W. Hart
Dept. of Biological Chemistry, Johns Hopkins University School of Medicine, 725 N. Wolf St. Rm., 401 Hunterian Baltimore, MD 21205-2185, USA
Search for more papers by this authorProf. Dr. Pierre Sinaý
Dept. de Chimie, URA 1686, Ecole Normale Supérieure, 24 rue Lhomond, 75231 Paris Cedex 05, France
Search for more papers by this authorFirst published: 27 July 2000
Summary
The prelims comprise:
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Introduction
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Oligosaccharide Synthesis
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Galactosyltransferase
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Immunoglobulin G
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Rheumatoid Arthritis
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Quantification of IgG sugars in RAr
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RAr and Pregnancy
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Tissue-specific Galactosyltransferase Abnormalities in an Experimental Model of Rheumatoid Arthritis
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Glycosylation Homeostasis within RAr Lymphocytes is Abnormal
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Are the Rheumatoid Arthritis Associated Glycosylation Abnormalities Unique?
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Sugar Printing Rheumatic Disease is Possible
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Rapid Profiling of IgG N-Glycans by Fluorophore-coupled Oligosaccharide Electrophoresis has the Potential of Differentiating Rheumatic Diseases
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In What Way could GTase Enzymatic Control be Abnormal?
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Conclusion
References
- Glycoimmunology II. Advances in experimental medicine and biology. Edited by J.S. Axford, Published by Plenum Press Vol. 435 (1996).
- Dwek RA., Glycobiology: Towards understanding the function of sugars (Wellcome Trust Award Lecture 1994) Biochem Soc Trans (1995) 23 (1) 1–25.
- Feizi T., Demonstration by monoclonal antibodies that carbohydrate structures of glycoproteins and glycolipids are onco-developmental antigens. Nature, 1985, 314: 53–57.
- Crocker PR & Feizi T., Carbohydrate recognition systems: functional triads in cell-cell interactions. Curr Opin Struct Biol (1996) 6 (5): 679–91.
- Axford JS, et al., 2nd Jenner International Glycoimmunology meeting. Ann Rheum Dis (1992) 1269–1985.
- Axford JS, et al., 3rd Jenner International Glycoimmunology meeting. Glycosylat Dis, 1994, 3: 197–227.
- Axford JS., 3rd Jenner International Glycoimmunology meeting. Immunol Today, 1993, 14 (3): 104–106.
- Axford JS., Trends. 2nd Jenner International Glycoimmunology meeting. Immunol Today, 1995, 16 (5): 213–215.
- Axford JS., Oligosaccharides: An optional extra or of relevance to disease mechanisms in rheumatology? J Rheumatol (1991) 18 (8): 1124–1127.
- Axford JS., Glycosylation and rheumatic disease: more than icing on the cake. J. Rheumatol, 1994, 21 (10): 1791–1795.
- Alavi A & Axford JS., Chapter: The glycosyltransferases from abnormalities of IgG glycosylation and immunological disorders. Edited by DA Isenberg & TW. Rademacher Published by John Wiley & Sons (1996).
-
Alavi A &
Axford JS.,
Glycoimmunology I.
Published by Plenum Press
(1995).
10.1007/978-1-4615-1885-3 Google Scholar
- Axford, JS., Glycosylation and Autoimmune Disease. Glycoconj J. (1996) 13: 893.
- Axford JS., 4th Jenner International Glycoimmunology Meeting: A Review. Immunol Today 1997; 18 (11): 511–513.
- Varki A., Biological roles of oligosaccharides: all of the theories are correct. Glycobiology, 1993, 3 (2): 97–130.
- Feizi T., Oligosaccharides that mediate mammalian cell-cell adhesion. Curr Opin Struct Biol, 1993, 3: 701–710.
- Hagopian A & Eylar EH., Glycoprotein biosynthesis: studies on the receptor specificity of the polypeptide: N-acetylglucosaminyl-transferase from bovine submaxillary glands. Arch Biochem Biophys, 1968, 128 (2): 422–433.
- Farquhar MG & Palade G., The golgi apparatus (complex)—(1954–81) from artifact to center stage. J Cell Biol (1981) 91 (3); 77–103.
- Roth J & Berger EG., Immunocytochemical localisation of galactosyltransferase in HeLa cells: co-distribution with thiamine pyrophosphatase in trans-Golgi cisternae. J Cell Biol, 1982, 93 (1): 223–229.
- Roth J, Taatjes DJ, Lucocq JM, Weinstein J, Paulson JC., Demonstration of an extensive transtubular network continuous with the Golgi apparatus stack that may function in glycosylation. Cell, 1985, 43 (1): 287–295.
- Rabouille C, Hui N, Hunte F, Kieckbusch R, Berger EG, Warren G, Nilsson T., Mapping the distribution of golgi enzymes involved in the construction of complex oligosaccharides. J Cell Sci (1995) 108 (4) 1617–1627.
- Roseman S., The synthesis of complex carbohydrates by multi-glycosyltransferase systems and their potential function in intercellular adhesion. Chem Phys Lipids, 1970, 5 (1): 270–297.
- Nilsson T & Warren G., Retention and retrieval in the endoplasmic reticulum and the golgi apparatus. Curr Opin Cell Biol, 1994, 6 (4): 517–521.
- Berger EG & Thumher M., Clues to the cell-specific synthesis of complex carbohydrates. News Physiol Sci, 1993, 8: 57–60.
- Berger EG, Thurnher M & Muller U., Galactosyltransferase and sialyltransferase are located in different sub-cellular compartments in HeLa cells. Exp Cell Res (EPB), 1987, 173: 267–273.
- Shur BD & Roth S., Cell surface glycosyltransferases. Biochem Biophys Acta, 1975, 415: 473–512.
- Schachter H & Roden L., The biosynthesis of animal glycoproteins. In: Metabolic Conjugation and Metabolic Hydrolysis. WH. Fishman Editor: Academic Press, New York pp. 1–149.
- McGuire EJ, Kerlin R, Cebra JJ & Roth S., A human milk galactosyltransferase is specific for secreted, but not plasma IgA. J Immunol, 1989, 143 (9): 2933–2938.
- Shaper NL, Shaper JH, Bertness V, Chang Hg, Kirsch IR and Hollis GF., The human galactosyltransferase gene is on chromosome 9 at band pl 3. Somatic Cell Mol Genet (1986) 12 (6) 633–6.
- Russo RN, Shaper NL and Shaper JHI., Bovine ǎ14 galactosyltransferase: two sets of mRNA transcripts encode two forms of the protein with different amino-terminal domains. In vitro translation experiments demonstrate that both the short and the long forms of the enzyme are type II membrane-bound glycoproteins. J Biol Chem, 1990, 265 (6): 3324–3331.
- Shur BD & Hall NG., Sperm surface galactosyltransferase activities during in vitro compaction. J Cell Biol, 1982, 95: 567–573.
- Bayna EM, Runyan RB, Scully NF, Reichner J, Lopez LC and Shur BD., Cell surface galactosyltransfer as a recognition molecule during development. Mol Cell Biochem, 1986, 72: 141–151.
- Bayna ME, Shaper JH & Shur BD., Temporally specific involvement of cell surface b1,4 galactosyltransferase during mouse embryo morula compaction. Cell, 1988, 53: 145–157.
- Begovac PC and Shur BD., Cell surface galactosyltransferase mediates the initiation of neutite outgrowth from PC12 cells on laminin. J. Biol Chem, 1990, 110 (2): 461–470.
- Parekh RB, Dwek RA, Sutton BJ, et al., Association of rheumatoid arthritis and primary osteoarthritis with changes in the glycosylation pattern of total serum IgG. Nature, 1985, 316: 452–457.
- Axford JS., Medicine Published by Blackwell Science 1996.
- Routier FH, Hounsell EF, Rudd PM, Takahashi N, Bond A, Hay FC, Alavi A, Axford JS and Jefferis R., Quantitation of the different oligosaccharides of human serum IgG from patients with rheumatoid arthritis: A critical evaluation of different methods. J Immunol Meths 1998; 213: 113–130.
- Alavi A, Arden N, Spector TD & Axford JS., IgG glycosylation changes are associated with the clinical outcome of rheumatoid arthritis in pregnancy. Arth Rheum 1997; 40 (9 S149) Suppl. No. 771.
- Havenaar EC, Axford JS, Brinkman-van der Linden ECM, Alavi A, Van Ommen ECR, van het Hof B, Spector T, Mackiewicz A & Dijk WV., Severe rheumatoid arthritis prohibits the pregnancy-induced decrease in α3-fucosylation of α1-acid glycoprotein. Glycoconj J, 1998, 15: 723–729.
- Soltys AJ, Hay FC, Bond A, Axford JS, Jones MG, Randen I, Thompson K & Natvig J., The binding of synovial tissue-derived human monoclonal immunoglobulin M rheumatoid factor to immunoglobulin G preparations of differing galactose content. Scan J Immunol, 1994, 40 (2): 135–143.
- Alavi A, Axford JS, Hay FC, Jones MG., Tissue-specific galactosyltransferase abnormalities in an experimental model of rheumatoid arthritis. Ann Med Intern, 1998, 149 (5): 251–260.
- Axford JS, Sumar N, Alavi A, Isenberg DA, Young A, Bodman KB, Roitt IM., Changes in normal glycosylation mechanisms in autoimmune rheumatic disease. J Clin Invest, 1992, 89 (3): 1021–1031.
- Bond A, Alavi A, Axford JS, Youinou P & Hay FC., The relationship between exposed galactose and N-acetylglucosamine residues on IgG in RA, JCA and Sjogren's syndrome. Clin Exp Immunol, 1996, 105: 99–103.
- Watson M, Rudd P, Dwek RA & Axford JS., Sugar printing rheumatic diseases: A potential method for diagnosis and differentiation using immunoglobulin G oligosaccharides. Arth Rheum (1996) 39 (9 216) Suppl. No. 1133.
- Frears ER, Merry AH and Axford JS., Rapid profiling of IgG N-glycans by fluorophore-coupled oligosaccharide electrophoresis has the potential of differentiating rheumatic diseases. Arth Rheum 1998; 41 (9 S85) Suppl. No. 317.
- Pool AJ, Alavi A & Axford JS., β1,4 galactosyltransferase isoenzyme changes in serum of patients with rheumatoid arthritis. Br J Rheumatol (1996) 35 (1 174): Suppl. No. 335.
