Noncardiac Problems of the Neonatal Period
James M. Greenberg MD
Division of Neonatology, Cincinnati Children's Hospital Research Foundation, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA
Search for more papers by this authorJames M. Greenberg MD
Division of Neonatology, Cincinnati Children's Hospital Research Foundation, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA
Search for more papers by this authorJames H. Moller MD
University of Minnesota, Minneapolis, MN, USA
Search for more papers by this authorJulien I. E. Hoffman MD, FRCP
University of California San Francisco, San Francisco, CA, USA
Search for more papers by this authorSummary
Preterm and premature neonates present unique medical problems which are challenging to manage and may complicate the care of those with congenital heart disease, particularly in the postoperative period. In this chapter, those affecting the lungs and intestinal system are stressed. Generally, the severity of the conditions is inversely related to weight and degree of prematurity, but even those closer to term may be affected. The pathophysiology, clinical findings, management, and sequellae are discussed.
References
- Mathews TJ, MacDorman MF. Infant mortality statistics from the 2005 period linked birth/infant death data set. Natl Vital Stat Rep 2008; 57: 1–32.
- Behrman R, Butler A, eds. Preterm Birth: Causes, Consequences, and Prevention. Washington, DC: Institute of Medicine, National Academy of Sciences, 2007.
- MacDonald H. Perinatal care at the threshold of viability. Pediatrics 2002; 110: 1024–7.
- Wood NS, Marlow N, Costeloe K, et al. Neurologic and developmental disability after extremely preterm birth. EPICure Study Group. N Engl J Med 2000; 343: 378–84.
- Lucey JF, Rowan CA, Shiono P, et al. Fetal infants: the fate of 4172 infants with birth weights of 401 to 500 grams – the Vermont Oxford Network experience (1996–2000). Pediatrics 2004; 113: 1559–66.
- Vohr BR, Wright LL, Poole WK, McDonald SA. Neurodevelopmental outcomes of extremely low birth weight infants <32 weeks' gestation between 1993 and 1998. Pediatrics 2005; 116: 635–43.
- Warner B, Musial MJ, Chenier T, Donovan E. The effect of birth hospital type on the outcome of very low birth weight infants. Pediatrics 2004; 113: 35–41.
- Kramer MS, Demissie K, Yang H, et al. The contribution of mild and moderate preterm birth to infant mortality. Fetal and Infant Health Study Group of the Canadian Perinatal Surveillance System. JAMA 2000; 284: 843–9.
- Escobar GJ, Clark RH, Greene JD. Short-term outcomes of infants born at 35 and 36 weeks gestation: we need to ask more questions. Semin Perinatol 2006; 30: 28–33.
- Kirkegaard I, Obel C, Hedegaard M, Henriksen TB. Gestational age and birth weight in relation to school performance of 10-year-old children: a follow-up study of children born after 32 completed weeks. Pediatrics 2006; 118: 1600–6.
- MacKay DF, Smith GC, Dobbie R, Pell JP. Gestational age at delivery and special educational need: retrospective cohort study of 407,503 schoolchildren. PLoS Med 2010; 7: e1000289.
- Laye MR, Dellinger EH. Timing of scheduled cesarean delivery in patients on a teaching versus private service: adherence to American College of Obstetricians and Gynecologists guidelines and neonatal outcomes. Am J Obstet Gynecol 2006; 195: 577–82; discussion 582–4.
- Costello JM, Polito A, Brown DW, et al. Birth before 39 weeks' gestation is associated with worse outcomes in neonates with heart disease. Pediatrics 2010; 126: 277–84.
- Yoon BH, Jun JK, Romero R, et al. Amniotic fluid inflammatory cytokines (interleukin-6, interleukin-1beta, and tumor necrosis factor-alpha), neonatal brain white matter lesions, and cerebral palsy. Am J Obstet Gynecol 1997; 177: 19–26.
- Kallapur SG, Jobe AH. Contribution of inflammation to lung injury and development. Arch Dis Child 2006; 91: F132–5.
- Watterberg KL, Demers LM, Scott SM, Murphy S. Chorioamnionitis and early lung inflammation in infants in whom bronchopulmonary dysplasia develops. Pediatrics 1996; 97: 210–5.
- Richardson BS, Wakim E, daSilva O, Walton J. Preterm histologic chorioamnionitis: impact on cord gas and pH values and neonatal outcome. Am J Obstet Gynecol 2006; 195: 1357–65.
- Halliday HL. Recent clinical trials of surfactant treatment for neonates. Biol Neonate 2006; 89: 323–9.
- Stevens TP, Harrington EW, Blennow M, Soll RF. Early surfactant administration with brief ventilation vs. selective surfactant and continued mechanical ventilation for preterm infants with or at risk for respiratory distress syndrome. Cochrane Database Syst Rev 2007;(4): CD003063.
- Northway WH Jr, Rosan RC, Porter DY. Pulmonary disease following respirator therapy of hyaline-membrane disease. Bronchopulmonary dysplasia. N Engl J Med 1967; 276: 357–68.
- Jobe AH, Bancalari E. Bronchopulmonary dysplasia. Am J Resp Crit Care Med 2001; 163: 1723–9.
- Walsh MC, Yao Q, Gettner P, et al. Impact of a physiologic definition on bronchopulmonary dysplasia rates. Pediatrics 2004; 114: 1305–11.
- Donn SM, Sinha SK. Minimising ventilator induced lung injury in preterm infants. Arch Dis Child 2006; 91: F226–30.
- Tyson JE, Wright LL, Oh W, et al. Vitamin A supplementation for extremely-low-birth-weight infants. National Institute of Child Health and Human Development Neonatal Research Network. N Engl J Med 1999; 340: 1962–8.
- Kinsella JP, Cutter GR, Walsh WF, et al. Early inhaled nitric oxide therapy in premature newborns with respiratory failure. N Engl J Med 2006; 355: 354–64.
- Ballard RA, Truog WE, Cnaan A, et al. Inhaled nitric oxide in preterm infants undergoing mechanical ventilation. N Engl J Med 2006; 355: 343–53.
- Baveja R, Christou H. Pharmacological strategies in the prevention and management of bronchopulmonary dysplasia. Semin Perinatol 2006; 30: 209–18.
- Anderson PJ, Doyle LW. Neurodevelopmental outcome of bronchopulmonary dysplasia. Semin Perinatol 2006; 30: 227–32.
- Lindner W, Pohlandt F, Grab D, Flock F. Acute respiratory failure and short-term outcome after premature rupture of the membranes and oligohydramnios before 20 weeks of gestation. J Pediatr 2002; 140; 177–82.
- Wu S, Johnson MP. Fetal lower urinary tract obstruction. Clin Perinatol 2009; 36: 377–90.
-
Burklow KA, Phelps AN, Schultz JR, et al. Classifying complex pediatric feeding disorders. J Pediatr Gastroenterol Nutr 1998; 27: 3–7.
10.1097/00005176-199808000-00003 Google Scholar
- Wang LY, Luo HJ, Hsieh WS, et al. Severity of bronchopulmonary dysplasia and increased risk of feeding desaturation and growth delay in very low birth weight preterm infants. Pediatr Pulmonol 2010; 45: 165–73.
- Singer LT, Davillier M, Preuss L, et al. Feeding interactions in infants with very low birth weight and bronchopulmonary dysplasia. J Dev Behav Pediatr 1996; 17 69–76.
- Kieffer J, Sapin E, Berg A, et al. Gastroesophageal reflux after repair of congenital diaphragmatic hernia. J Pediatr Surg 1995; 30: 1330–3.
- Muratore CS, Utter S, Jaksic T, et al. Nutritional morbidity in survivors of congenital diaphragmatic hernia. J Pediatr Surg 2001; 36: 1171–6.
- Lemons JA, Bauer CR, Oh W, et al. Very low birth weight outcomes of the National Institute of Child Health and Human Development Neonatal Research Network, January 1995 through December 1996. NICHD Neonatal Research Network. Pediatrics 2001; 107: E1.
- McElhinney DB, Hedrick HL, Bush DM, et al. Necrotizing enterocolitis in neonates with congenital heart disease: risk factors and outcomes. Pediatrics 2000; 106: 1080–7.
- Bell MJ, Ternberg JL, Feigin RD, et al. Neonatal necrotizing enterocolitis. Therapeutic decisions based upon clinical staging. Ann Surg 1978; 187: 1–7.
- Walsh MC, Kliegman RM. Necrotizing enterocolitis: treatment based on staging criteria. Pediatr Clin North Am 1986; 33: 179–201.
- Deshpande G, Rao S, Patole S, Bulsara M. Updated meta-analysis of probiotics for preventing necrotizing enterocolitis in preterm neonates. Pediatrics 2010; 125: 921–30.
- Maisels MJ. Neonatal jaundice. Pediatr Rev 2006; 2: 443–54.
- Dennery PA, Seidman DS, Stevenson DK. Neonatal hyperbilirubinemia. N Engl J Med 2001; 344: 581–90.
- Bental YA, Shiff Y, Dorsht N, et al. Bhutani-based nomograms for the prediction of significant hyperbilirubinaemia using transcutaneous measurements of bilirubin. Acta Paediatr 2009; 98: 1902–8.
- Huizing K, Roislien J, Hansen T. Intravenous immune globulin reduces the need for exchange transfusions in Rhesus and AB0 incompatibility. Acta Paediatr 2008; 97: 1362–5.
- Hill A. Intraventricular hemorrhage: emphasis on prevention. Semin Pediatr Neurol 1998; 5: 152–60.
- Wilson-Costello D, Friedman H, Minich N, et al. Improved neurodevelopmental outcomes for extremely low birth weight infants in 2000–2002. Pediatrics 2007; 119: 37–45.
- Volpe JJ. Brain injury in the premature infant: overview of clinical aspects, neuropathology, and pathogenesis. Semin Pediatr Neurol 1998; 5: 135–51.
- Golden JA, Gilles FH, Rudelli R, Leviton A. Frequency of neuropathological abnormalities in very low birth weight infants. J Neuropathol Exp Neurol 1997; 56: 472–8.