Antipsychotic Medications and their use in First‐Episode Psychosis - Promoting Recovery in Early Psychosis - Wiley Online Library

NMHDU Joint National Early Intervention Programme, Lead and Worcestershire EI Clinical Development Lead, Worcestershire Mental Health Partnership NHS Trust, Worcestershire, UK

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David Shiers,

David Shiers

NMHDU Joint National Early Intervention Programme Lead Worcestershire, UK

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Mandy Reed,

Mandy Reed

Consultant Nurse

Early Intervention in Psychosis, Bath, UK

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Mark Rayne,

Mark Rayne

Programme Specialist

Service Development NHS West Midlands Regional, Development Centre, West Midlands, UK

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First published: 26 March 2010

https://doi.org/10.1002/9781444318814.ch9

Citations: 2

Summary

This chapter contains sections titled:

Introduction
A brief summary of the evidence
Why is medication being prescribed? Are there any alternatives?
Implementation into practice
What medication is being prescribed? Are there any differences between drugs?
Implementation into practice
Implementation into practice
What dose is being prescribed? I need it to work but want to avoid side effects
What if my medication doesn't help?
Implementation into practice
Implementation into practice
Are any tests needed before the drug is started? What about monitoring?
Implementation into practice
What if a few doses are missed?
Implementation into practice
When can I stop taking the tablets and what might happen? Will I have to take them again?
Implementation into practice
Implementation and conclusions
Suggested further reading
References

Suggested further reading

Taylor, D., Paton, C. & Kerwin, R. (2007). The Maudsley Prescribing Guidelines ( 9th edition). Informa Healthcare.
10.1201/b21605
Google Scholar
International Early Psychosis Association Writing Group (2005). International clinical practice guidelines for early psychosis. British Journal of Psychiatry, 187 (Suppl. 48), s120–s124.
10.1192/bjp.187.48.s120
Google Scholar
Remington, R. (2005). Rational pharmacotherapy in early psychosis. British Journal of Psychiatry, 187 (Suppl. 48), s77–s84.
10.1192/bjp.187.48.s77
Web of Science® Google Scholar
Thomas, C. & Lewis, S. (1998). Which atypical antipsychotic? British Journal of Psychiatry, 172, 106–109.
10.1192/bjp.172.2.106
CAS PubMed Web of Science® Google Scholar
References
Google Scholar
Aguilar, E.J., Keshavan, M.S., Martinez-Quiles, M.D. et al. (1994). Predictors of acute dystonia in first-episode psychotic patients. American Journal of Psychiatry, 151, 1819–1821.
10.1176/ajp.151.12.1819
CAS PubMed Web of Science® Google Scholar
Barnett, J.H., Werners, U., Secher, S.M. et al. (2007). Substance use in a population-based clinic sample of people with first-episode psychosis. The British Journal of Psychiatry, 190 515–520.
10.1192/bjp.bp.106.024448
PubMed Web of Science® Google Scholar
Claassen, D., Fakhoury, W.K., Ford, R. & Priebe, S. (2007). Money for medication: financial incentives to improve medication adherence in assertive out-reach. Psychiatric Bulletin, 31, 4–7.
10.1192/pb.31.1.4
Google Scholar
Crow, T.J., MacMillan, J.F., Johnson, A.L. & Johnstone, E.C. (1986). The Northwick Park study of first episode schizophrenia II. A randomised controlled trial of prophylactic neuroleptic treatment. British Journal of Psychiatry, 148, 120–127.
10.1192/bjp.148.2.120
PubMed Web of Science® Google Scholar
Gaebel, W. & Riesbeck, M. (2007). Results of the German Research Network on Schizophrenia (GRNS): Prodrome-based treatment in first-episode schizophrenia. European Psychiatry, 22 (Suppl. 1), S76.
10.1016/j.eurpsy.2007.01.293
Web of Science® Google Scholar
Gaebel, W., Janner, M., Frommann, N. et al. (2002). First vs multiple episode schizophrenia: Two-year outcome of intermittent and maintenance medication strategies. Schizophrenia Research, 53, 145–159.
10.1016/S0920-9964(01)00182-7
PubMed Web of Science® Google Scholar
Gilbert, P.L., Harris, M.J., McAdams, L.A. et al. (1995). Neuroleptic withdrawal in schizophrenic patients: A review of the literature. Archives of General Psychiatry, 52, 173–188.
10.1001/archpsyc.1995.03950150005001
CAS PubMed Web of Science® Google Scholar
Gitlin, M., Neuchterlein, K., Subotnik, K.L. et al. (2001). Clinical outcomes following neuroleptic discontinuation in patients with remitted recent-onset schizophrenia. American Journal of Psychiatry, 158, 1835–1842.
10.1176/appi.ajp.158.11.1835
CAS PubMed Web of Science® Google Scholar
Gray, R., Wykes, T.M., Edmunds, M. et al. (2004). Effect of a medication management training package for nurses on clinical outcomes for patients with schizophrenia: A cluster randomised controlled trial. British Journal of Psychiatry, 185, 157–162.
10.1192/bjp.185.2.157
PubMed Web of Science® Google Scholar
Jones, S., Hemingway, S. & Williams, B. (2007). Mental Health Nurses as non-medical prescribers – Entering uncharted territory. Mental Health Nursing, 27 (1), 14–17.
Google Scholar
Kemp, R., Kirov, G., Everitt, B. et al. (1998). Randomised controlled trial of compliance therapy. 18-month follow-up. British Journal of Psychiatry, 172, 413–419.
10.1192/bjp.172.5.413
CAS PubMed Web of Science® Google Scholar
Latter, S. (2005). Promoting concordance in prescribing interactions: The evidence base and implications for new generations of prescribers. In: M. Courtney & M. Griffiths (eds), Independent and Supplementary Prescribing – An Essential Guide. Cambridge: Cambridge Press.
Google Scholar
Lieberman, J., Jody, D., Geisler, S. et al. (1993). Time course and biological correlates of treatment response in first-episode schizophrenia. Archives of General Psychiatry, 50, 369–376.
10.1001/archpsyc.1993.01820170047006
PubMed Web of Science® Google Scholar
Leucht, S., Busch, R., Kissling, W. & Kane, J.M. (2007). Early predictors of antipsychotic nonresponse among patients with schizophrenia. Journal of Clinical Psychiatry, 68, 352–360.
10.4088/JCP.v68n0301
CAS PubMed Web of Science® Google Scholar
National Institute for Clinical Excellence (2002). Guidance on the use of newer (atypical) antipsychotic drugs for the treatment of schizophrenia. Health Technology Appraisal No. 43.
Google Scholar
Robinson, D.G., Woerner, M.G., McMeniman, M., Mendelowitz, A. & Bilder, R.M. (2004). Symptomatic and functional recovery from a first episode of schizophrenia or schizoaffective disorder. American Journal of Psychiatry, 161, 473–479.
10.1176/appi.ajp.161.3.473
PubMed Web of Science® Google Scholar
Walburn, J., Gray, R., Gournay, K. et al. (2001). Systematic review of patient and nurse attitudes to depot antipsychotic medication. British Journal of Psychiatry, 179, 300–307.
10.1192/bjp.179.4.300
CAS PubMed Web of Science® Google Scholar
Weiden, P.J., Preskorn, S.H., Fahnestock, P.A. et al. (2007). Translating the psychopharmacology of antipsychotics to individualized treatment for severe mental illness: A roadmap. The Journal of Clinical Psychiatry, 68 (Suppl. 7), 34–36.
PubMed Web of Science® Google Scholar
Wiersma, D., Wunderink, A., Nienhuis, F.J. & Sytema, S. (2007). The MESIFOS-trial: Treatment strategies in remitted first episode psychosis. European Psychiatry, 22 (Suppl. 1), S76–S77.
10.1016/j.eurpsy.2007.01.294
Web of Science® Google Scholar
World Health Organisation and the International Early Psychosis Association (2005). Early intervention and recovery for young people with early psychosis: Consensus statement. British Journal of Psychiatry, 187 (Suppl. 48), s116–s119.
Google Scholar
Wunderink, L., Nienhuis, F., Sytema, S. et al. (2007). Guided discontinuation versus maintenance treatment in remitted first-episode psychosis: Relapse rates and functional outcome. Journal of Clinical Psychiatry, 68, 654–661.
10.4088/JCP.v68n0502
PubMed Web of Science® Google Scholar
Wyatt, R.J., Damiani, M. & Henter, I.D. (1998). First-episode schizophrenia. Early intervention and medication discontinuation in the context of course and treatment. British Journal of Psychiatry, 172 (Suppl. 33), 77–83.
CAS PubMed Web of Science® Google Scholar

Citing Literature

Promoting Recovery in Early Psychosis: A Practice Manual