Three-dimensional (3D) printing is becoming increasingly commonplace in healthcare facilities, and the sophistication of the models and tools that can be produced with it is expanding. While the expansion is certainly promising, it also increases the chance of mistakes and lowers the quality of the end product for patients. It is more important than ever to have a solid quality management system (QMS) in place to help detect and prevent errors, lessen the impact of those that do occur, and improve the overall quality of the product given to patients. Without knowing whether or not the traditional care methods are helping or hurting, continuing to repeat them is counterproductive to patient care. Measuring, refining, and improving the process-level repetitive operations inside 3D printing leads to high-quality results in the same way that it does in any other industry. The authors discuss the trials and tribulations they encountered in implementing a QMS into their 3D-printing operations. They describe problems that arose and how they were fixed as well as how they have worked to increase uniformity, streamline communication, and repeat past triumphs. They clearly explain the importance of collaboration between healthcare professionals, regulatory bodies, and established manufacturers in achieving the ultimate aim of patient safety and satisfaction.