Seizures are frequently encountered conditions by EMS personnel. Often, the situation has stabilized prior to EMS arrival. When seizure activity persists, it represents a medical emergency, and terminating it can reduce subsequent morbidity. The history is important to determine if the seizure is provoked, secondary to a medical issue that may require additional intervention, or epileptic, without a known cause. While EMS clinicians should be alert for evidence of trauma, general use of backboards to restrict spinal motion is not indicated. Benzodiazepines are the mainstay of emergency anticonvulsant treatment for status epilepticus. Administration should be prompt and in adequate doses. Multiple potential routes of administration may be effective.