Carbon fiber reinforced polymer (CFRP) composites possess high strength and become accessible materials to be utilized in the automotive and aerospace industries due to their unique and superior mechanical properties like high strength-to-weight ratios and stiffness-to-weight ratios. In all the machining operations, the most commonly performed process is drilling. Delamination is a significant disadvantage while drilling composites. Therefore, this work aims to present an experimental study of drilling behaviour that describes the effect of drilling process parameters such as feed rate and spindle speed on delamination by using a statistical approach called the Design of Experiments (DOE). This technique minimizes the number of tests required during manufacturing and maximizes the amount of account information. CFRP material “FMS 2275_Type1_Class1” is used for the experiment by a Taguchi L16 orthogonal array. There are three types of drillbit materials that were selected: “HSS Drill, Kevlar Drill, and Polycrystalline Diamond Drill (PCD).” After the experimental study, the most effective drillbit PCD is used and the effect of drilling process parameters on delamination was studied further. The C-scan technique analyzes the delamination around the hole of the CFRP panel. The results obtained from these experiments show that at high spindle speed and lower feed rate, heat generation due to friction effect between cutting edges and the work material causes softening of the composite matrix, which results in inferior surface finish but lowers the delamination.