Plants experience many biotic and abiotic stresses with diverse modes of attack throughout their lifetime. Plant hormones such as ethylene, jasmonate, abscisic acid, auxin, brassinosteroid, gibberellic acid, etc., organize efficient defense responses by triggering the expression of defense genes. Recent research findings have assisted in illuminating the elaborate signaling networks and complicated crosstalk among hormone signaling pathways. In this chapter, we review the function of the major plant hormones in regulating abiotic and biotic stress responses with a particular focus on the importance of crosstalk between hormones in creating a complicated and proficient stress response. The elaborate network of crosstalk between the signaling intermediates is just beginning to be understood. Hence, determining additional information about crosstalk mechanisms among various hormones in stress responses will be a significant topic in the field of abiotic stress research.