Phagocytes
Fernando O Martinez
Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK
Search for more papers by this authorGiuseppe Teti
Scylla Biotech S.r.l., University of Messina, Messina, Italy
Search for more papers by this authorSiamon Gordon
Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan City, Taiwan
Sir William Dunn School of Pathology, University of Oxford, Oxford, UK
Search for more papers by this authorFernando O Martinez
Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK
Search for more papers by this authorGiuseppe Teti
Scylla Biotech S.r.l., University of Messina, Messina, Italy
Search for more papers by this authorSiamon Gordon
Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan City, Taiwan
Sir William Dunn School of Pathology, University of Oxford, Oxford, UK
Search for more papers by this authorAdam J Mead PhD, FRCP, FRCPath, FMedSci
Haematopoietic Stem Cell Biology Laboratory, Medical Research Council Molecular Haematology Unit, Medical Research Council Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK
Search for more papers by this authorMichael A Laffan DM, MRCP, FRCPath
Department of Immunology and Inflammation, Faculty of Medicine, Imperial College London, London, UK
Search for more papers by this authorGraham P Collins DPhil, FRCP, FRCPath
Department of Haematology, Oxford Cancer and Haematology Centre, Oxford, UK
Search for more papers by this authorDeborah Hay DPhil, MRCP, FRCPath
Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, Oxford, UK
Search for more papers by this authorA Victor Hoffbrand MA, DM, FRCP, FRCPath, FRCP (Edin), DSc, FMedSci
Emeritus Professor of Haematology Honorary Consultant Haematologist
University College London, London, UK
Royal Free Hospital, London, UK
Search for more papers by this authorSummary
The phagocyte lineage plays a crucial role in the immune system eliminating and destroying pathogens. In this chapter we examine neutrophils, eosinophils, basophils, mast cells, monocytes, macrophages, dendritic cells, and multinucleated cells, and provide a comprehensive view of the system's complexity. The chapter covers key aspects of the phagocyte system, beginning with an overview of its lineage. We discuss phagocyte identification and quantification methods and provide insights into the tools used to study their function. General phagocyte molecules are explored in the context of their diverse roles in the immune response. The process of phagocytosis, adhesion and chemotaxis mechanisms, are detailed to illustrate how phagocytes locate and engulf foreign particles. Additionally, we cover killing mechanisms such lytic enzymes and reactive radicals. We conclude by addressing disorders within the phagocyte system, including congenital disorders in neutrophils and genetic perspectives on monocyte/macrophage-related disorders.
Selected bibliography
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