Chapter 9

Optical Coherence Tomography, Near-Infrared Spectroscopy, and Near-Infrared Fluorescence Molecular Imaging

First published: 06 May 2022

Summary

Intravascular optical coherence tomography (OCT) is a high-resolution imaging technology through fiber optics. OCT requires replacing blood with transparent crystalloids.

Various characteristics of coronary lesions can be classified by utilizing different tissues properties. The unique ability of OCT to identify plaque rupture erosion offers a major added value in the characterization of acute coronary syndromes. Thanks to the sharp delineation of lumen contours provided by OCT, this technology can provide automatic lumen measurements, suggest the best optimization in percutaneous coronary intervention, detect even subclinical dissections and fractures after lithotripsy or atherectomy procedures.

Near-infrared spectroscopy is a imaging technique that can distinguish plaque composition through its “chemogram” obtained by absorbance and reflectance of near-infrared light.

Near-infrared fluorescence molecular imaging is a promising coronary intravascular imaging that aims to molecules and cells involved in the pathogenesis of vascular disease.

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