Living Donor Liver Transplant in Children
Adebowale A. Adeyemi
Liver Transplant Program, Nemours/Alfred I. duPont Hospital for Children, Wilmington, DE, USA
Search for more papers by this authorElizabeth B. Rand
Liver Transplant Program, The Children's Hospital of Philadelphia, Philadelphia, PA, USA
Search for more papers by this authorKim M. Olthoff
Liver Transplant Program, The Children's Hospital of Philadelphia, Philadelphia, PA, USA
Division of Transplant Surgery, The Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA
Search for more papers by this authorAdebowale A. Adeyemi
Liver Transplant Program, Nemours/Alfred I. duPont Hospital for Children, Wilmington, DE, USA
Search for more papers by this authorElizabeth B. Rand
Liver Transplant Program, The Children's Hospital of Philadelphia, Philadelphia, PA, USA
Search for more papers by this authorKim M. Olthoff
Liver Transplant Program, The Children's Hospital of Philadelphia, Philadelphia, PA, USA
Division of Transplant Surgery, The Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA
Search for more papers by this authorJames Neuberger DM, FRCP
Honorary Consultant Physician
Queen Elizabeth Hospital, Birmingham, UK
Search for more papers by this authorJames Ferguson MD, FRCPE
Consultant Hepatologist
Queen Elizabeth Hospital and Hon Reader in Medicine, University of Birmingham, Birmingham, UK
Search for more papers by this authorPhilip N. Newsome PhD, FRCPE
Professor of Experimental Hepatology and Director of the Centre for Liver and Gastrointestinal Research Consultant Transplant Hepatologist
University of Birmingham
Queen Elizabeth Hospital, Birmingham, UK
Search for more papers by this authorMichael Ronan Lucey MD, FRCPI
Professor of Medicine and Chief
Division of Gastroenterology and Hepatology, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
Search for more papers by this authorSummary
The disparity between the number of appropriately sized deceased donor liver grafts and number of children awaiting liver transplant continues to be significant and has led to increasing use of technical variant grafts, including living donor liver grafts. With increasing use of these grafts, technical advancements have been made, leading to safer donor procedures and increasing graft and recipient survival. There remains an overall expertise gap when comparing the use of living donors for pediatric transplants in the US versus other countries where living donor liver transplantation (LDLT) is the norm. Increasing use of technical variant grafts and living donor grafts will not only close this gap, but further decrease wait-list mortality in the very young children who are currently disadvantaged. The major disadvantage of LDLT is the fact that a healthy individual is subjected to a major surgery with potential medical or surgical complications, including death.
Further reading
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