Percutaneous coronary intervention (PCI) of chronic total occlusion (CTO) is considered as the major frontier in interventional cardiology. Repeated wire manipulations to redirect the guidewire into the CTO body can result in extensive subintimal dissection with accompanying extramural hematoma. The parallel-wire technique has two main purposes: redirecting a wire inside the body of the CTO, and puncture of the distal CTO fibrous cap. The parallel-wire technique can be used with different aims, at different stages of the CTO recanalization: exchanging wires inside a CTO; finding a new channel inside the CTO body; and puncture of the distal CTO fibrous cap. Parallel-wire technique can be applied to all CTOs, irrespective of the individual lesion characteristics. The parallel-wire technique significantly increases the success rate in percutaneous CTO recanalization via antegrade route.