Infectious Injury to Bone Marrow
K. Jane Wardrop
Search for more papers by this authorK. Jane Wardrop
Search for more papers by this authorMarjory B. Brooks DVM, DACVIM
Director, Comparative Coagulation Section
Animal Health Diagnostic Center, Cornell University, Ithaca, New York, USA
Search for more papers by this authorKendal E. Harr DVM, MS, DACVP
URIKA, LLC, Mukilteo, Washington, USA
Search for more papers by this authorDavis M. Seelig DVM, PhD, DACVP
Associate Professor, Clinical Pathology
Department of Veterinary Clinical Sciences, University of Minnesota, College of Veterinary Medicine, St. Paul, Minnesota, USA
Search for more papers by this authorK. Jane Wardrop DVM, MS, DACVP
Professor and Director, Clinical Pathology Laboratory
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, Washington, USA
Search for more papers by this authorDouglas J. Weiss DVM, PhD, DACVP
Emeritus Professor
College of Veterinary Medicine, University of Minnesota, St. Paul, Minnesota, USA
Search for more papers by this authorSummary
The response of the bone marrow to infectious agents is variable, depending on the organism involved, the nature and chronicity of infection, and the presence of other diseases. The marrow response to common companion or domestic animal infectious diseases known for their marrow involvement is described in this chapter. Bacteria within the families Rickettsiaceae and Anaplasmataceae of the order Rickettsiales cause a variety of diseases in dogs, cats, horses, and cattle; however, marrow changes are best documented for infections caused by Ehrlichia canis . Leishmaniasis is a disease caused by protozoal organisms of the genus Leishmania , and is transmitted in Mediterranean regions by the bite of an infected female sand fly. Blastomycosis, histoplasmosis, coccidioidomycosis, and cryptococcosis are common systemic fungal diseases of the dog and cat. Although all of these diseases can involve the bone marrow, marrow involvement is most frequently described in histoplasmosis.
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