Chapter 11
Vesiculopustular, Bullous and Erosive Diseases of the Neonate
Caroline Mahon,
Anna E. Martinez,
Caroline Mahon
Department of Dermatology, Bristol Royal Infirmary, University Hospitals Bristol NHS Foundation Trust, Bristol, UK
Search for more papers by this authorAnna E. Martinez
Paediatric Dermatology Department, Great Ormond St Hospital for Children NHS Trust, London, UK
Search for more papers by this authorCaroline Mahon,
Anna E. Martinez,
Caroline Mahon
Department of Dermatology, Bristol Royal Infirmary, University Hospitals Bristol NHS Foundation Trust, Bristol, UK
Search for more papers by this authorAnna E. Martinez
Paediatric Dermatology Department, Great Ormond St Hospital for Children NHS Trust, London, UK
Search for more papers by this authorBook Editor(s):Peter Hoeger,
Veronica Kinsler,
Albert Yan,
John Harper,
Arnold Oranje,
Christine Bodemer,
Margarita Larralde,
David Luk, Vibhu Mendiratta,
Diana Purvis,
Peter Hoeger
Search for more papers by this authorVeronica Kinsler
Search for more papers by this authorAlbert Yan
Search for more papers by this authorJohn Harper
Search for more papers by this authorArnold Oranje
Search for more papers by this authorChristine Bodemer
Search for more papers by this authorMargarita Larralde
Search for more papers by this authorVibhu Mendiratta
Search for more papers by this authorDiana Purvis
Search for more papers by this authorFirst published: 20 November 2019
Summary
The skin of the neonate must make a rapid adaptation to extrauterine life. A number of benign physiological vesiculopustular and bullous skin lesions present in the newborn period and these probably represent adaptive events as the skin of the neonate becomes accustomed to a low-humidity environment, is colonized with commensal organisms and matures as an environmental barrier. Distinguishing between cutaneous eruptions that represent benign or transient physiological cutaneous phenomena, infections, inflammatory dermatoses and genodermatoses is essential to guide clinical management.
References
- Moosavi Z, Hosseini T. One year survey of cutaneous lesions in 1000 consecutive newborns. Pediatr Dermatol 2006; 23: 61–3.
- Rivers JK, Frederiksen PC, Dibdin C. A prevalence survey of dermatosis in the Australian neonate. J Am Acad Dermatol 1990; 23: 77–81.
- Ferahbas A, Utas S, Akcakus M et al. Prevalence of cutaneous findings in hospitalized neonates: a prospective observational study. Pediatr Dermatol 2009; 26: 139–42.
- Ekiz Ö, Gül Ü, Mollamahmutoğlu L et al. Skin findings in newborns and their relationship with maternal factors: observational research. Ann Dermatol 2013; 25: 1–4.
- Luna PC, Larralde M. Profuse congenital familial milia with absent dermatoglyphics (Basan's Syndrome): description of a new family. Pediatr Dermatol 2012; 29: 527–9.
- Lloyd BM, Braverman AC, Anadkat MJ. Multiple facial milia in patients with Loeys-Dietz syndrome. Arch Dermatol 2011; 147: 223–6.
- Epstein W, Klingman AM. The pathogenesis of milia and benign tumors of the skin. J Invest Dermatol 1956; 26: 1–11.
- Hidano A, Purwoko R, Jitsukawa K. Statistical survey of skin changes in Japanese neonates. Pediatr Dermatol 1986; 3: 140–4.
- Shelley WB, Horvath PN. Experimental miliaria in man; production of sweat retention anidrosis and miliaria crystallina by various kinds of injury. J Invest Dermatol 1950; 14: 9–20.
- Haas N, Henz BM, Weigel H. Congenital miliaria crystallina. J Am Acad Dermatol 2002; 47(5 Suppl): S270–2.
- Babu TA, Sharmila V. Congenital miliaria crystallina in a term neonate born to a mother with chorioamnionitis. Pediatr Dermatol 2012; 29:3.
- Argoubi H, Fitchner C, Richard O et al. [Pustular miliaria rubra and systemic type 1b pseudohypoaldosteronism in a newborn]. Ann Dermatol Venereol 2007; 134(3 Pt 1): 253–6.
- Monteagudo B, Labandeira J, Cabanillas M et al. Prospective study of erythema toxicum neonatorum: Epidemiology and predisposing factors. Pediatr Dermatol 2012; 29: 166–8.
- Haveri FTTS, Inamadar AC. A cross-sectional prospective study of cutaneous lesions in newborn. ISRN Dermatology 2014: 360590.
- Zagne V, Fernandes NC. Dermatoses in the first 72 h of life: A clinical and statistical survey. Indian J Dermatol Venereol Leprol 2011; 77: 470–6.
- Sadana DJ, Sharma YK, Chaudhari ND et al. A clinical and statistical survey of cutaneous changes in the first 120 hours of life. Indian J Dermatol 2014; 59: 552–7.
- Kulkarni ML, Singh R. Normal variants of skin in neonates. Indian J Dermatol Venereol Leprol 1996; 62: 83–6.
- Sachdeva M, Kaur S, Nagpal M et al. Cutaneous lesions in newborn. Indian J Dermatol Venereol Leprol 2002; 68: 334–7.
- Liu C, Feng J, Qu R et al. Epidemiologic study of the predisposing factors in erythema toxicum neonatorum. Dermatology 2005; 210: 269–72.
- Gokdemir G, Erdogan HK, Koslu A et al. Cutaneous lesions in Turkish neonates born in a teaching hospital. Indian J Dermatol Venereol Leprol 2009; 75: 638.
- Menni S, Boccardi D, Crosti C. Neonatal toxic erythema: clinico-epidemiologic characteristics and recent pathogenic hypothesis. Pediatr Med Chir 2005; 27: 22–5.
- Leung AK. Erythema toxicum neonatorum present at birth. J Singapore Paediatr Soc 1986; 28: 163–6.
- Maffei FA, Michaels MG, Wald ER. An unusual case of erythema toxicum scrotal pustules present at birth. Arch Pediatr Adolesc Med; 150: 649–50.
- Plantin P et la Société française de dermatopédiatrie. Érythème toxique du nouveau-né. Ann Dermatol Venereol 2010; 137: 150–2.
- Ramamurthy RS, Reveri M, Esterly NB et al. Transient neonatal pustular melanosis. J Pediatr; 88: 831–5.
- Ferrándiz C, Coroleu W, Ribera M et al. Sterile transient neonatal pustulosis is a precocious form of erythema toxicum neonatorum. Dermatology 1992; 185: 18–22.
- Finelt N, Kristal L. Patient characteristics of neonatal eosinophilic pustulosis. Pediatr Dermatol 2013; 30: e204–7.
- Ofuji S, Ogino A, Horio T et al. Eosinophilic pustular folliculitis. Acta Derm Venereol 1970; 50: 195–203.
- Giard F, Marcoux D, McCuaig C et al. Eosinophilic pustular folliculitis (Ofuji disease) in childhood: a review of four cases. Pediatr Dermatol 1991; 8: 189–93.
- Kasai Y, Uchida S, Sakuma M. Eosinophilic pustular folliculitis. Jpn J Dermatol 1981; 91: 1029–35.
- Lucky AW, Esterly NB, Heskel N et al. Eosinophilic pustular folliculitis in infancy. Paediatr Dermatol 1984; 1: 202–6.
- Taieb A, Basan-Andrieu L, Maleville J. Eosinophilic pustulosis of the scalp in childhood. J Am Acad Dermatol 1992; 27: 55–60.
- Asgari M, Leiferman KM, Piepkorn M et al. Neonatal eosinophilic pustulosis. Int J Dermatol 2006; 45: 131–4.
- Vicente J, España A, Idoate M et al. Are eosinophilic pustular folliculitis of infancy and infantile acropustulosis the same entity? Br J Dermatol 1996; 135: 807–9.
- Picone Z, Madile BM. Eosinophilic pustular folliculitis (Ofuji's disease) in a newborn. Pediatr Dermatol 1992; 9: 178.
- Buckley DA, Munn SE, Higgins EM. Neonatal eosinophilic pustular folliculitis. Clin Exp Dermatol 2001; 26: 251–5.
- Hernandez–Martin A, Nuno-Gonzalez A, Colmenero I et al. Eosinophilic pustular folliculitis in infancy: a series of 15 cases and review of the literature. J Am Acad Dermatol 2012; 68: 150–5.
- Nomora T, Katoh M, Yamamoto Y et al. Eosinophilic pustular folliculitis: The transition in sex differences and interracial characteristics between 1965 and 2013. J Dermatol 2015; 42: 343–52.
- Ramdial PK, Morar N, Dlova et al. HIV-associated eosinophilic folliculitis in an infant. Am J Dermatopathol 1999; 126: 29–31.
- Bull RH, Harland CA, Fallowfield ME et al. Eosinophilic folliculitis: a self-limiting illness in patients being treated for haematological malignancy. Br J Dermatol 1993; 129: 178–82.
- Rybojad M, Guibal F, Vignon-Pennamen MD et al. [Eosinophilic pustulosis in an infant accompanied by immune deficit]. Ann Dermatol Venereol 1999; 126: 29–31.
- Eberting CL, Davis J, Puck JM et al. Dermatitis and the newborn rash of hyper-IgE syndrome in infants and children. Arch Dermatol 2004; 140: 1119–25.
- Miura H, Shoda Y, Adachi J. Eosinophilic pustular folliculitis in infancy in a Japanese neonate. Pediatr Dermatol 2004; 21: 615–16.
- Ota T, Hata Y, Tanikawa A et al. Eosinophilic pustular folliculitis (Ofuji disease): indomethacin as a first choice of treatment. Clin Exp Dermatol 2001; 26: 179–81.
- Toyonaga E, Abe R, Moriuchi R et al. Indomethacin for refractory infantile eosinophilic pustular folliculitis. JAMA Dermatol 2013; 149: 367–8.
- Patel NP, Laguda B, Roberts NM et al. Treatment of eosinophilic pustulosis of infancy with topical tacrolimus. (Letter). Br J Dermatolol 2012; 167: 184–95.
- Imai M, Katho S, Sakamoto K et al. A case of eosinophilic pustular folliculitis in a child started initially only with plantar pustular lesions. Rinsho Hifuka 2011; 65: 227–330.
- Kahn G, Rywlin AM. Acropustulosis of infancy. Arch Dermatol 1979; 115: 831–3.
- Jarrat M, Ramsdell W. Infantile acropustulosis. Arch Dermatol. 1979; 115: 834–6.
- Kahn G. Reply. (Letter). J Am Acad Dermatol 1984; 11: 896.
- Good L, Good T, High W. Infantile acropustulosis in internationally adopted children. J Am Acad Dermatol 2011; 65: 763–71.
- Mancini AJ, Frieden IJ, Paller AS. Infantile acropustulosis revisited: history of scabies and response to topical corticosteroids. Pediatr Dermatol 1998; 15: 337–41.
- Dromy R, Raz A, Metzker, MD. Infantile acropustulosis. Pediatr Dermatol 1991; 8: 284–87.
- Elpern DJ. Infantile acropustulosis and antecedent scabies. (Letter). J Am Acad Dermatol 1984; 11: 895.
- Prendiville JS. Infantile acropustulosis – how often is it a sequela of scabies? Pediatr Dermatol 1995; 12: 275–6.
- Bjornberg A, Friis B. Persistent pustulosis in children adopted from Asia; a sequel of scabies? Int J Dermatol 1978; 17: 69–73.
- Truong AL, Truong MD, Esterly N. Atypical acropustulosis of infancy. Int J Dermatol 1997; 36: 677–99.
- Kimura M, Higuchi T, Yoshida M. Infantile acropustulosis treated successfully with topical maxacalcitol. Acta Derm Venerol 2010; 91: 363–4.
- Lucky AW, McGuire JS. Infantile acropustulosis with eosinophilic pustules. J Pediatr 1982; 100: 428–9.
- Falanga V. Infantile acropustulosis with eosinophilia. J Am Acad Dermatol 1985; 13: 826–8.
- Vignon-Pennamen MD, Wallach D. Infantile acropustulosis. Arch Dermatol 1986; 122: 1155–60.
- Bernier V, Weill FX, Hirigoyen V et al. Skin colonization by Malassezia species in neonates: a prospective study and relationship with neonatal cephalic pustulosis. Arch Dermatol 2002; 138: 215–18.
- Ayhan M, Sancak B, Karaduman A et al. Colonisation of neonate skin by Malassezia species: Relationship with neonatal cephalic pustulosis J Am Acad Dermatol 2007; 57: 1012–18.
- Aractingi S, Cadranel S, Reygagne P et al. Pustulose neonatale induite par Malazessia furfur. Ann Dermatol Venereol 1991; 118: 856–8.
- Rapelanoro R, Mortureux P, Couprie B et al. Neonatal Malazessia furfur pustulosis. Arch Dermatol 1996; 132: 190–3.
- Bardazzi F. Transient cephalic neonatal pustulosis. Arch Dermatol 1997; 133: 528–30.
- Niamba P, Weill FX, Sarlangue J et al. Is common neonatal cephalic pustulosis (neonatal acne) triggered by Malassezia sympoialis? Arch Dermatol 1998; 134: 995–8.
- Roberts SO. Pityrosporum orbiculare: incidence and distribution on clinically normal skin. Br J Dermatol 1969; 81: 264–9.
-
Koseki S, Takahashi S. Serial observations on the colonization of Pityrosporum obiculare (ovale) on the facial skin surface of newborn infants. Jpn J Med Mycol 1998; 29: 209–15.
10.3314/jjmm1960.29.209 Google Scholar
- Grattan CE, Peachey RD, Boon A. Evidence for a role of local trauma in the pathogenesis of erosive pustular dermatosis of the scalp. Clin Exp Dermatol 1988; 13: 7–10.
- Pye RJ, Peachey RD, Burton JL. Erosive pustular dermatosis of the scalp. Br J Dermatol 1979; 100: 559–66.
- Siegel D, Holland K, Philips R et al. Erosive dermatosis of the scalp after perinatal scalp injury. Pediatr Dermatol 2006; 23: 533–6.
- Shimada R, Masu T, Hanamizu H et al. Infantile erosive pustular dermatosis of the scalp associated with Klippel Feil syndrome. Acta Derm Venerol 2010; 90: 200–1.
- Sheckter C, Rommer E, Francis C et al. Scalp erosion in ankyloblepharon-ectodermal defect-cleft lip and/or palate (AEC syndrome): treatment with a cellular dermal matrix. J Craniofac Surg 2013; 24: e28–30.
- Broussard KC, Berger TG, Rosenblum et al. Erosive pustular dermatosis of the scalp: A review with a focus on dapsone therapy. J Am Acad Dermatol 2012; 66: 680–6.
- Turrentine JE, Sokumbi O, Agim NG. Blisters and erosions in a neonate. JAMA Dermatol 2014; 150: 1223–4.
- Zhao CY, Murrell DF. Blistering diseases in neonates. Curr Opin Pediatr 2016; 28: 500–6.
- Al-Mutairi N, Sharma AK, Zaki A et al. Maternal and neonatal pemphigoid gestationis. Clin Exp Dermatol 2004; 29: 202–4.
- Abrams ML, Smidt A, Benjamin L et al. Congenital epidermolysis bullosa acquisita: vertical transfer of maternal autoantibody from mother to infant. Arch Dermatol 2011; 147: 337–41.
- Lorente Lavirgen AI, Bernabeu-Wittel J, Dominguez-Cruz J et al. Neonatal pemphigus foliaceus. J Pediatr 2012; 161: 768.
- Daneshpazhooh M, Chams-Davatchi C, Valikhani M et al. Pemphigus and pregnancy: a 23-year experience. Indian J Dermatol Venereol Leprol 2011; 77: 534.
- Zhao CY, Chiang YZ, Murrell DF. Neonatal autoimmune blistering disease: a systematic review. Pediatr Dermatol 2016; 33: 367–74.
- Kardos M, Levine D, Gürcan HM et al. Pemphigus vulgaris in pregnancy: analysis of current data on the management and outcomes. Obstet Gynecol Surv 2009; 64: 739–49.
- Itsukaichi M, Takakuwa K, Yamaguchi M et al. Twins with neonatal pemphigus vulgaris born to a mother with pemphigus vulgaris: a case report. Pediatr Dermatol 2013; 30: e59–60.
- Wu H, Wang ZH, Yan A et al. Protection against pemphigus foliaceus by desmoglein 3 in neonates. N Engl J Med 2000; 343: 31–5.
- Julapalli MR, Brandon KL, Rosales CM et al. Neonatal linear immunoglobulin a bullous dermatosis: a rare presentation. Pediatr Dermatol 2012; 29: 610–13.
- Zone JJ, Taylor TB, Meyer LJ et al. The 97 kDA linear IgA bullous disease antigen is identical to a portion of the extracellular domain of the 180kDa bullous pemphigoid antigen BPAg2. J Invest Dermatol 1998; 110: 207–10.
- Sachs JA, Leonard J, Awad J et al. A comparative serological and molecular study of linear IgA disease and dermatitis herpetiformis. Br J Dermatol 1988; 118: 759–64.
- Gluth MB, Witman PM, Thompson DM. Upper aerodigestive tract complications in a neonate with linear IgA bullous dermatosis. Int J Pediatr Otorhinolaryngol 2004; 68: 965–70.
- Hurza LL, Mallory SB, Fitzgibbons J et al. Linear IgA bullous dermatitis in a neonate. Pediatr Dermatol 1993; 10: 171–6.
- Smahi A, Courtois G, Vabres P et al. Genomic rearrangement in NEMO impairs NF-kappaB activation and is a cause of incontinentia pigmenti. The International Incontinentia Pigmenti (IP) Consortium. Nature 2000; 405: 466–72.
- Orphanet Report Series. Prevalence and incidence of rare diseases: Bibliographic data. 2018. Listed in alphabetical order of disease or group of diseases: http://www.orpha.net/orphacom/cahiers/docs/GB/Prevalence_of_rare_diseases_by_alphabetical_list.pdf (accessed 16 October 2018).
- Minić S, Trpinac D, Obradović M. Incontinentia pigmenti diagnostic criteria update. Clin Genet 2014; 85: 536–42.
- Fusco F, Bardaro T, Fimiani G et al. Molecular analysis of the genetic defect in a large cohort of IP patients and identification of novel NEMO mutations interfering with NF-kappaB activation. Hum Mol Genet 2004; 13: 1763–73.
- Carney RG Jr. Incontinentia pigmenti: a world statistical analysis. Arch Dermatol 1976; 112: 535–42.
- Minic S, Trpinac D, Obradovic M. Systematic review of central nervous system anomalies in incontinentia pigmenti. Orphanet J Rare Dis 2013; 8: 25.
- Pinheiro A, Mathew MC, Thomas M et al. The clinical profile of children in India with pigmentary anomalies along the lines of Blaschko and central nervous system manifestations. Pediatr Dermatol 2007; 24: 11–17.
- Minic S, Obradovic M, Kovacevic I et al. Ocular anomalies in incontinentia pigmenti: literature review and meta-analysis. Srp Arh Celok Lek 2010; 138: 408–13.
- Phan TA, Wargon O, Turner AM. Incontinentia pigmenti case series: clinical spectrum of incontinentia pigmenti in 53 female patients and their relatives. Clin Exp Dermatol 2005; 30: 474–80.
- François J. Incontinentia pigmenti (Bloch-Sulzberger syndrome) and retinal changes. Br J Ophthalmol 1984; 68: 19–25.
- Swinney CC, Han DP, Karth PA. Incontinentia pigmenti: a comprehensive review and update. Ophthalmic Surg Lasers Imaging Retina 2015; 46: 650–7.
- Wang X, Reid-Sutton V, Omar-Peraza-Llanes J et al. Mutations in X-linked PORCN, a putative regulator of Wnt signalling, cause of focal dermal hypoplasia. Nat Genet 2007; 39: 836–38.
- Bostwick B, Van den Veyver IB, Sutton VR. Focal dermal hypoplasia. In: MP Adam, HH Ardinger, RA Pagon et al (eds) GeneReviews® [Internet]. Seattle: University of Washington, Seattle:1993–2019 (updated 21 July 2016).
- Navarro CL, Esteves-Vieira V, Courrier S et al. New ZMPSTE24 (FACE1) mutations in patients affected with restrictive dermopathy or related progeroid syndromes and mutation update. Eur J Hum Genet 2014; 22: 1002–11.
- Ahmad Z, Phadke SR, Arch E et al. Homozygous null mutations in ZMPSTE24 in restrictive dermopathy: evidence of genetic heterogeneity. Clin Genet 2012; 81: 158–64.
- Matulevičienė A, Meškienė R, Morkūnienė A et al. Frame shift mutations of the ZMPSTE24 gene in two siblings with restrictive dermopathy. Clin Dysmorphol. 2016; 25(1): 7–11.
- Bodemer C, Hermine O, Palmérini F et al. Pediatric mastocytosis is a clonal disease associated with D816V and other activating c-KIT mutations. J Invest Dermatol 2010; 130: 804–15.
- Hartmann K, Escribano L, Grattan C et al. Cutaneous manifestations in patients with mastocytosis: Consensus report of the European Competence Network on Mastocytosis; the American Academy of Allergy, Asthma & Immunology; and the European Academy of Allergology and Clinical Immunology. J Allergy Clin Immunol 2016; 137: 35–45.
- Koga H, Kokubo T, Akaishi M et al. Neonatal onset diffuse cutaneous mastocytosis: a case report and review of the literature. Pediatr Dermatol 2011; 28: 542–6.
- Waters WJ, Lacson PS. Mast cell leukemia presenting as urticaria pigmentosa. Pediatrics 1957; 19: 1033–42.
- Brockow K, Akin C, Huber M et al. Assessment of the extent of cutaneous involvement in children and adults with mastocytosis: relationship to symptomatology, tryptase levels, and bone marrow pathology. J Am Acad Dermatol 2003; 48: 508–16.
- Arock M, Akin C, Hermine O, Valent P. Current treatment options in patients with mastocytosis: status in 2015 and future perspectives. Eur J Haematol 2015; 94: 474–90.
- Brockow K, Jofer C, Behrendt H et al. Anaphylaxis in patients with mastocytosis: a study on history, clinical features and risk factors in 120 patients. Allergy 2008; 63: 226–32.
- Renke J, Lange M. Routine vaccinations in diffuse cutaneous mastocytosis. J Allergy Clin Immunol Pract 2016; 4: 190.
- Stephan M J, Smith D W, Powzi J W et al. Origin of scalp aplasia cutis. J Pediatr 1982; 101: 850–3.
- Marneros AG. Genetics of aplasia cutis reveal novel regulators of skin morphogenesis. J Invest Dermatol 2015; 135: 666–72.
- Tlougan BE, Paller AS, Schaffer JV et al. Congenital erosive and vesicular dermatosis with reticulated supple scarring: unifying clinical features. J Am Acad Dermatol 2013; 69: 909–15.
- Sadick NS, Shea CR, Schlessel JS. Congenital erosive and vesicular dermatosis with reticulated supple scarring: a neutrophilic dermatosis. J Am Acad Dermatol 1995; 32: 44–8.
- Sidhu-Malik NK, Resnick SD, Wilson BB. Congenital erosive and vesicular dermatosis healing with reticulated supple scarring: report of three new cases and review of the literature. Pediatr Dermatol 1998; 15: 214–18.
- De Lange A, Bayet B, Debauche C et al. Congenital erosive and vesicular dermatosis with reticulated scarring in a newborn: an innovative treatment using a silicone dressing. Pediatr Dermatol 2009; 26: 735–8.
