Chapter 68
Henoch–Schonlein Purpura Glomerulonephritis and IgA Nephropathy in Children
Myda Khalid,
Sharon Phillips Andreoli,
Myda Khalid
Department of Pediatrics Division of Pediatric Nephrology and Hypertension, James Whitcomb Riley Hospital for Children Indiana University Medical Center, Indianapolis, IN, USA
Search for more papers by this authorSharon Phillips Andreoli
Department of Pediatrics, James Whitcomb Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, IN, USA
Search for more papers by this authorMyda Khalid,
Sharon Phillips Andreoli,
Myda Khalid
Department of Pediatrics Division of Pediatric Nephrology and Hypertension, James Whitcomb Riley Hospital for Children Indiana University Medical Center, Indianapolis, IN, USA
Search for more papers by this authorSharon Phillips Andreoli
Department of Pediatrics, James Whitcomb Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, IN, USA
Search for more papers by this authorBook Editor(s):Jonathan C. Craig MBChB, DipCH, MMed(Clin Epi), PhD, FAHMS,
Donald A. Molony MD,
Giovanni F.M. Strippoli MD, PhD, MPH, MM (Epi),
Jonathan C. Craig MBChB, DipCH, MMed(Clin Epi), PhD, FAHMS
Matthew Flinders Distinguished Professor Vice President and Executive Dean
College of Medicine and Public Health, Flinders University, Adelaide, Australia
Search for more papers by this authorDonald A. Molony MD
Professor of Medicine Distinguished Teaching Professor of the University of Texas System
Division of Renal Diseases and Hypertension AND Center for Clinical Research and Evidence-based Medicine, McGovern Medical School University of Texas, Houston, TX, USA
Search for more papers by this authorGiovanni F.M. Strippoli MD, PhD, MPH, MM (Epi)
Professor of Nephrology Adjunct Professor of Epidemiology
Department of Emergency and Organ Transplantation – University of Bari, Bari, Italy
School of Public Health, University of Sydney, Sydney, NSW, Australia
Search for more papers by this authorFirst published: 18 November 2022
Summary
Henoch–Schonlein purpura (HSP) nephritis and IgA nephropathy are the two most common glomerular diseases occurring in children characterized by predominant glomerular IgA deposits. While IgA nephropathy is a renally limited glomerular disorder, HSP nephritis is associated with extrarenal involvement including the typical rash, arthralgia, arthritis, and gastrointestinal involvement. HSP are anecdotal reports and despite extensive investigation there is no clear pathogen that is accepted as a trigger for the clinical manifestations of HSP. IgA nephropathy comprises mesangial deposition of IgA within the glomerulus. The light microscopy findings on renal biopsy in patients with IgA nephropathy can range from near normal appearing glomeruli to a rapidly progressing glomerulonephritis picture with cellular crescents. Limited evidence-based recommendations can be made for the treatment of IgA nephropathy and HSP nephritis in children due to overall lack of controlled low risk of bias studies in this population.
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