Chronic Kidney Disease and Hypertension
Branko Braam
Division of Nephrology, Department of Medicine, University of Alberta, Canada
Search for more papers by this authorBranko Braam
Division of Nephrology, Department of Medicine, University of Alberta, Canada
Search for more papers by this authorJonathan C. Craig MBChB, DipCH, MMed(Clin Epi), PhD, FAHMS
Matthew Flinders Distinguished Professor Vice President and Executive Dean
College of Medicine and Public Health, Flinders University, Adelaide, Australia
Search for more papers by this authorDonald A. Molony MD
Professor of Medicine Distinguished Teaching Professor of the University of Texas System
Division of Renal Diseases and Hypertension AND Center for Clinical Research and Evidence-based Medicine, McGovern Medical School University of Texas, Houston, TX, USA
Search for more papers by this authorGiovanni F.M. Strippoli MD, PhD, MPH, MM (Epi)
Professor of Nephrology Adjunct Professor of Epidemiology
Department of Emergency and Organ Transplantation – University of Bari, Bari, Italy
School of Public Health, University of Sydney, Sydney, NSW, Australia
Search for more papers by this authorSummary
Hypertension is not only highly prevalent in patients with chronic kidney disease (CKD), it is also one of the most prevalent causes of progressive kidney injury and end-stage kidney disease. In the context of clinical evaluation of the patient with CKD, four different assessments of blood pressure (BP) are being used: in-office manual, multiple in-office automated, home, and ambulatory measurements. Volume overload is the consequence of a too excessive sodium intake and the impaired ability of the kidney to excrete sodium at normal arterial pressures. Renal artery stenosis also leads to diagnostic and therapeutic dilemmas. There are numerous studies in the literature about weight loss and its effects on BP, whether by dietary or pharmacological intervention or by bariatric surgery. Hypertension is not only prevalent in patients with CKD, it is also a key factor to control cardiovascular events in patients with CKD and to prevent progression of CKD itself.
References
- Kidney Disease Outcomes Quality I ( 2004 ). K/DOQI clinical practice guidelines on hypertension and antihypertensive agents in chronic kidney disease . Am. J. Kidney Dis. 43 : S1 – S290 .
- Braam , B. , Taler , S.J. , Rahman , M. et al. ( 2017 ). Recognition and management of resistant hypertension . Clin. J. Am. Soc. Nephrol. 12 : 524 – 535 .
- Carey , R.M. , Calhoun , D.A. , Bakris , G.L. et al. and on behalf of the American Heart Association Professional/Public Education and Publications Committee of the Council on Hypertension; Council on Cardiovascular and Stroke Nursing; Council on Clinical Cardiology; Council on Genomic and Precision Medicine; Council on Peripheral Vascular Disease; Council on Quality of Care and Outcomes Research; and Stroke Council ( 2018 ). Resistant hypertension: detection, evaluation, and management: a scientific statement from the American Heart Association . Hypertension 72 : e53 – e90 .
- Egan , B.M. , Zhao , Y. , Axon , R.N. et al. ( 2011 ). Uncontrolled and apparent treatment resistant hypertension in the United States, 1988 to 2008 . Circulation 124 : 1046 – 1058 .
- Muntner , P. , Davis , B.R. , Cushman , W.C. et al. and ALLHAT Collaborative Research Group ( 2014 ). Treatment-resistant hypertension and the incidence of cardiovascular disease and end-stage renal disease: results from the antihypertensive and lipid-lowering treatment to prevent heart attack trial (ALLHAT) . Hypertension 64 : 1012 – 1021 .
- Thomas , G. , Xie , D. , Chen , H.Y. et al. CRIC Study Investigators ( 2016 ). Prevalence and prognostic significance of apparent treatment resistant hypertension in chronic kidney disease: report from the chronic renal insufficiency cohort study . Hypertension 67 : 387 – 396 .
- Judd , E. and Calhoun , D.A. ( 2014 ). Apparent and true resistant hypertension: definition, prevalence and outcomes . J. Hum. Hypertens. 28 : 463 – 468 .
- Bobrie , G. , Chatellier , G. , Genes , N. et al. ( 2004 ). Cardiovascular prognosis of “masked hypertension” detected by blood pressure self-measurement in elderly treated hypertensive patients . JAMA 291 : 1342 – 1349 .
- Drawz , P.E. , Brown , R. , De Nicola , L. et al. ( 2018 ). Variations in 24-hour BP profiles in cohorts of patients with kidney disease around the world: the I-DARE study . Clin. J. Am. Soc. Nephrol. 13 : 1348 – 1357 .
- Liu , J.E. , Roman , M.J. , Pini , R. et al. ( 1999 ). Cardiac and arterial target organ damage in adults with elevated ambulatory and normal office blood pressure . Ann. Intern. Med. 131 : 564 – 572 .
- Agarwal , R. , Pappas , M.K. , and Sinha , A.D. ( 2016 ). Masked uncontrolled hypertension in CKD . J. Am. Soc. Nephrol. 27 : 924 – 932 .
- Scheppach , J.B. , Raff , U. , Toncar , S. et al. ( 2018 ). Blood pressure pattern and target organ damage in patients with chronic kidney disease . Hypertension 72 : 929 – 936 .
- Gorostidi , M. , Sarafidis , P.A. , de la Sierra , A. et al. ( 2013 ). Differences between office and 24-hour blood pressure control in hypertensive patients with CKD: a 5,693-patient cross-sectional analysis from Spain . Am. J. Kidney Dis. 62 : 285 – 294 .
- Chapman , A.B. , Johnson , A. , Gabow , P.A. , and Schrier , R.W. ( 1990 ). The renin-angiotensin-aldosterone system and autosomal dominant polycystic kidney disease . N. Engl. J. Med. 323 : 1091 – 1096 .
- Stone , R.A. , Tisher , C.C. , Hawkins , H.K. , and Robinson , R.R. ( 1974 ). Juxtaglomerular hyperplasia and hyperreninemia in progressive systemic sclerosis complicated acute renal failure . Am. J. Med. 56 : 119 – 123 .
- Cogan , M.G. ( 1990 ). Angiotensin II: a powerful controller of sodium transport in the early proximal tubule . Hypertension 15 : 451 – 458 .
- Koomans , H.A. , Roos , J.C. , Dorhout Mees , E.J. , and Delawi , I.M. ( 1985 ). Sodium balance in renal failure. A comparison of patients with normal subjects under extremes of sodium intake . Hypertension 7 : 714 – 721 .
- Kalainy , S. , Reid , R. , Jindal , K. et al. ( 2015 ). Fluid volume expansion and depletion in hemodialysis patients lack association with clinical parameters . Can. J. Kidney Health Dis. 2 : 54 .
- Hecking , M. , Moissl , U. , Genser , B. et al. ( 2018 ). Greater fluid overload and lower interdialytic weight gain are independently associated with mortality in a large international hemodialysis population . Nephrol. Dial. Transplant. 33 : 1832 – 1842 .
- Converse , R.L. Jr. , Jacobsen , T.N. , Toto , R.D. et al. ( 1992 ). Sympathetic overactivity in patients with chronic renal failure . N. Engl. J. Med. 327 : 1912 – 1918 .
- Ligtenberg , G. , Blankestijn , P.J. , Oey , P.L. et al. ( 1999 ). Reduction of sympathetic hyperactivity by enalapril in patients with chronic renal failure . N. Engl. J. Med. 340 : 1321 – 1328 .
- Smithwick , R.H. and Thompson , J.E. ( 1953 ). Splanchnicectomy for essential hypertension; results in 1,266 cases . J. Am. Med. Assoc. 152 : 1501 – 1504 .
- Bhatt , D.L. , Kandzari , D.E. , O'Neill , W.W. et al. and SYMPLICITY HTN-3 Investigators ( 2014 ). A controlled trial of renal denervation for resistant hypertension . N. Engl. J. Med. 370 : 1393 – 1401 .
- Grassi , G. , Arenare , F. , Pieruzzi , F. et al. ( 2009 ). Sympathetic activation in cardiovascular and renal disease . J. Nephrol. 22 : 190 – 195 .
- Vallance , P. , Leone , A. , Calver , A. et al. ( 1992 ). Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure . Lancet 339 : 572 – 575 .
- Investigators , A. , Wheatley , K. , Ives , N. et al. ( 2009 ). Revascularization versus medical therapy for renal-artery stenosis . N. Engl. J. Med. 361 : 1953 – 1962 .
- Bax , L. , Woittiez , A.J. , Kouwenberg , H.J. et al. ( 2009 ). Stent placement in patients with atherosclerotic renal artery stenosis and impaired renal function: a randomized trial . Ann. Intern. Med. 150 : 840 – 848 . W150–1.
- Cooper , C.J. , Murphy , T.P. , Cutlip , D.E. et al. ( 2014 ). Stenting and medical therapy for atherosclerotic renal-artery stenosis . N. Engl. J. Med. 370 : 13 – 22 .
- Slovut , D.P. and Olin , J.W. ( 2004 ). Fibromuscular dysplasia . N. Engl. J. Med. 350 : 1862 – 1871 .
- Lewis , E.J. , Hunsicker , L.G. , Bain , R.P. , and Rohde , R.D. ( 1993 ). The effect of angiotensin-converting-enzyme inhibition on diabetic nephropathy. The Collaborative Study Group . N. Engl. J. Med. 329 : 1456 – 1462 .
- Klahr , S. , Levey , A.S. , Beck , G.J. et al. ( 1994 ). The effects of dietary protein restriction and blood-pressure control on the progression of chronic renal disease. Modification of Diet in Renal Disease Study Group . N. Engl. J. Med. 330 : 877 – 884 .
- The GISEN Group (Gruppo Italiano di Studi Epidemiologici in Nefrologia) ( 1997 ). Randomised placebo-controlled trial of effect of ramipril on decline in glomerular filtration rate and risk of terminal renal failure in proteinuric, non-diabetic nephropathy . Lancet 349 : 1857 – 1863 .
- Ruggenenti , P. , Perna , A. , Gherardi , G. et al. ( 1999 ). Renoprotective properties of ACE-inhibition in non-diabetic nephropathies with non-nephrotic proteinuria . Lancet 354 : 359 – 364 .
- Lewis , E.J. , Hunsicker , L.G. , Clarke , W.R. et al. ( 2001 ). Renoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes . N. Engl. J. Med. 345 : 851 – 860 .
- Brenner , B.M. , Cooper , M.E. , de Zeeuw , D. et al. ( 2001 ). Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy . N. Engl. J. Med. 345 : 861 – 869 .
- Wright , J.T. Jr. , Bakris , G. , Greene , T. et al. ( 2002 ). Effect of blood pressure lowering and antihypertensive drug class on progression of hypertensive kidney disease: results from the AASK trial . JAMA 288 : 2421 – 2431 . African American Study of Kidney Disease and Hypertension Study Group
- Agodoa , L.Y. , Appel , L. , Bakris , G.L. et al., African American Study of Kidney Disease and Hypertension Study Group ( 2001 ). Effect of ramipril vs amlodipine on renal outcomes in hypertensive nephrosclerosis: a randomized controlled trial . JAMA 285 : 2719 – 2728 .
- Bakris , G.L. , Weir , M.R. , Shanifar , S. et al. and RENAAL Study Group ( 2003 ). Effects of blood pressure level on progression of diabetic nephropathy: results from the RENAAL study . Arch. Intern. Med. 163 : 1555 – 1565 .
- Ruggenenti , P. , Perna , A. , Loriga , G. et al. ( 2005 ). Blood-pressure control for renoprotection in patients with non-diabetic chronic renal disease (REIN-2): multicentre, randomised controlled trial . Lancet 365 : 939 – 946 .and REIN-2 Study Group
- Rahman , M. , Pressel , S. , Davis , B.R. et al. ( 2005 ). Renal outcomes in high-risk hypertensive patients treated with an angiotensin-converting enzyme inhibitor or a calcium channel blocker vs a diuretic: a report from the antihypertensive and lipid-lowering treatment to prevent heart attack trial (ALLHAT) . Arch. Intern. Med. 165 : 936 – 946 .
- Sarnak , M.J. , Greene , T. , Wang , X. et al. ( 2005 ). The effect of a lower target blood pressure on the progression of kidney disease: long-term follow-up of the modification of diet in renal disease study . Ann. Intern. Med. 142 : 342 – 351 .
- Papademetriou , V. , Zaheer , M. , Doumas , M. et al. and ACCORD Study Group ( 2016 ). Cardiovascular outcomes in action to control cardiovascular risk in diabetes: impact of blood pressure level and presence of kidney disease . Am. J. Nephrol. 43 : 271 – 280 .
- SPRINT Reasearch Group , Wright , J.T. Jr. , Williamson , J.D. et al. ( 2015 ). A randomized trial of intensive versus standard blood-pressure control . N. Engl. J. Med. 373 : 2103 – 2116 .
- Manjunath , G. , Tighiouart , H. , Ibrahim , H. et al. ( 2003 ). Level of kidney function as a risk factor for atherosclerotic cardiovascular outcomes in the community . J. Am. Coll. Cardiol. 41 : 47 – 55 .
- Keith , D.S. , Nichols , G.A. , Gullion , C.M. et al. ( 2004 ). Longitudinal follow-up and outcomes among a population with chronic kidney disease in a large managed care organization . Arch. Intern. Med. 164 : 659 – 663 .
- Cheung , A.K. , Rahman , M. , Reboussin , D.M. et al. and SPRINT Research Group ( 2017 ). Effects of intensive BP control in CKD . J. Am. Soc. Nephrol. 28 : 2812 – 2823 .
- Lambers Heerspink , H.J. , Holtkamp , F.A. , Parving , H.H. et al. ( 2012 ). Moderation of dietary sodium potentiates the renal and cardiovascular protective effects of angiotensin receptor blockers . Kidney Int. 82 : 330 – 337 .
- Mills , K.T. , Chen , J. , Yang , W. et al. and Chronic Renal Insufficiency Cohort Study Investigators ( 2016 ). Sodium excretion and the risk of cardiovascular disease in patients with chronic kidney disease . JAMA 315 : 2200 – 2210 .
- Sacks , F.M. , Svetkey , L.P. , Vollmer , W.M. et al. and DASH-Sodium Collaborative Research Group ( 2001 ). Effects on blood pressure of reduced dietary sodium and the dietary approaches to stop hypertension (DASH) diet. DASH-Sodium Collaborative Research Group . N. Engl. J. Med. 344 : 3 – 10 .
- McMahon , E.J. , Campbell , K.L. , Bauer , J.D. , and Mudge , D.W. ( 2015 ). Altered dietary salt intake for people with chronic kidney disease . Cochrane Database Syst. Rev .: CD010070.
- McMahon , E.J. , Bauer , J.D. , Hawley , C.M. et al. ( 2013 ). A randomized trial of dietary sodium restriction in CKD . J. Am. Soc. Nephrol. 24 : 2096 – 2103 .
- Chade , A.R. and Hall , J.E. ( 2016 ). Role of the renal microcirculation in progression of chronic kidney injury in obesity . Am. J. Nephrol. 44 : 354 – 367 .
- Docherty , N.G. , Canney , A.L. , and le Roux , C.W. ( 2015 ). Weight loss interventions and progression of diabetic kidney disease . Curr. Diab. Rep. 15 : 55 .
- Eidemak , I. , Haaber , A.B. , Feldt-Rasmussen , B. et al. ( 1997 ). Exercise training and the progression of chronic renal failure . Nephron 75 : 36 – 40 .
- Robinson-Cohen , C. , Littman , A.J. , Duncan , G.E. et al. ( 2014 ). Physical activity and change in estimated GFR among persons with CKD . J. Am. Soc. Nephrol. 25 : 399 – 406 .
- Hedayati , S.S. , Elsayed , E.F. , and Reilly , R.F. ( 2011 ). Non-pharmacological aspects of blood pressure management: what are the data? Kidney Int. 79 : 1061 – 1070 .
- Griffin , K.A. and Bidani , A.K. ( 2006 ). Progression of renal disease: renoprotective specificity of renin-angiotensin system blockade . Clin. J. Am. Soc. Nephrol. 1 : 1054 – 1065 .
- Bakris , G.L. and Weir , M.R. ( 2000 ). Angiotensin-converting enzyme inhibitor-associated elevations in serum creatinine: Is this a cause for concern? Arch. Intern. Med. 160 : 685 – 693 .
- Kanno , Y. , Okada , H. , Saruta , T. , and Suzuki , H. ( 2000 ). Blood pressure reduction associated with preservation of renal function in hypertensive patients with IgA nephropathy: a 3-year follow-up . Clin. Nephrol. 54 : 360 – 365 .
- Osawa , Y. , Narita , I. , Imai , N. et al. ( 2001 ). Determination of optimal blood pressure for patients with IgA nephropathy based on renal histology . Hypertens. Res. 24 : 89 – 92 .
- Schrier , R.W. , Abebe , K.Z. , Perrone , R.D. et al. and HALT-PKD Trial Investigators ( 2014 ). Blood pressure in early autosomal dominant polycystic kidney disease . N. Engl. J. Med. 371 : 2255 – 2266 .
- Whelton , P.K. , Carey , R.M. , Aronow , W.S. et al. ( 2018 ). 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA guideline for the prevention, detection, evaluation, and Management of High Blood Pressure in adults: executive summary: a report of the American College of Cardiology/American Heart Association task force on clinical practice guidelines . Circulation 138 : e426 – e483 .
- Williams , B. , Mancia , G. , Spiering , W. et al. and ESC Scientific Document Group ( 2018 ). 2018 ESC/ESH guidelines for the management of arterial hypertension . Eur. Heart J. 39 : 3021 – 3104 .
- Waeber , B. , Gavras , I. , Brunner , H.R. et al. ( 1982 ). Prediction of sustained antihypertensive efficacy of chronic captopril therapy: relationships to immediate blood pressure response and control plasma renin activity . Am. Heart J. 103 : 384 – 390 .
- Gaddam , K.K. , Nishizaka , M.K. , Pratt-Ubunama , M.N. et al. ( 2008 ). Characterization of resistant hypertension: association between resistant hypertension, aldosterone, and persistent intravascular volume expansion . Arch. Intern. Med. 168 : 1159 – 1164 .
- Arcand , J. , Abdulaziz , K. , Bennett , C. et al. ( 2014 ). Developing a web-based dietary sodium screening tool for personalized assessment and feedback . Appl. Physiol. Nutr. Metab. 39 : 413 – 414 .
- Klein , I.H. , Ligtenberg , G. , Neumann , J. et al. ( 2003 ). Sympathetic nerve activity is inappropriately increased in chronic renal disease . J. Am. Soc. Nephrol. 14 : 3239 – 3244 .
- de Champlain , J. , Cousineau , D. , and Lapointe , L. ( 1980 ). Evidences supporting an increased sympathetic tone and reactivity in a subgroup of patients with essential hypertension . Clin. Exp. Hypertens. 2 : 359 – 377 .
- Mahmud , A. , Mahgoub , M. , Hall , M. , and Feely , J. ( 2005 ). Does aldosterone-to-renin ratio predict the antihypertensive effect of the aldosterone antagonist spironolactone? Am. J. Hypertens. 18 : 1631 – 1635 .
- Parthasarathy , H.K. , Alhashmi , K. , McMahon , A.D. et al. ( 2010 ). Does the ratio of serum aldosterone to plasma renin activity predict the efficacy of diuretics in hypertension? Results of RENALDO . J. Hypertens. 28 : 170 – 177 .
- Egan , B.M. , Zhao , Y. , Li , J. et al. ( 2013 ). Prevalence of optimal treatment regimens in patients with apparent treatment-resistant hypertension based on office blood pressure in a community-based practice network . Hypertension 62 : 691 – 697 .
- Schersten , B. , Thulin , T. , Kuylenstierna , J. et al. ( 1980 ). Clinical and biochemical effects of spironolactone administered once daily in primary hypertension. Multicenter Sweden study . Hypertension 2 : 672 – 679 .
- Engbaek , M. , Hjerrild , M. , Hallas , J. , and Jacobsen , I.A. ( 2010 ). The effect of low-dose spironolactone on resistant hypertension . J. Am. Soc. Hypertens. 4 : 290 – 294 .