Chapter 4
Panic Disorder and Agoraphobia
Lily A. Brown,
Michelle G. Craske,
Lily A. Brown
Search for more papers by this authorMichelle G. Craske
Search for more papers by this authorLily A. Brown,
Michelle G. Craske,
Lily A. Brown
Search for more papers by this authorMichelle G. Craske
Search for more papers by this authorBook Editor(s):Dean McKay,
Jonathan S. Abramowitz,
Eric A. Storch,
Dean McKay
Search for more papers by this authorJonathan S. Abramowitz
Search for more papers by this authorEric A. Storch
Search for more papers by this authorSummary
This chapter reviews the empirically validated explanatory models of panic disorder and agoraphobia. It discusses common barriers to success in treatment for panic disorder and agoraphobia, with an emphasis on the application of experimental findings to clinical populations. Anxiety sensitivity (AS), or the belief that anxiety symptoms are harmful, plays a prominent role in the development of panic disorder and agoraphobia. The interoceptive conditioning model of panic disorder suggests that minor changes in physiology become associated with more extreme, innately aversive surges of autonomic arousal, such that benign physical sensations evoke a conditioned fear response or a full-blown panic attack. The chapter provides more detail about nuances of panic and agoraphobia presentation that can hinder the success of traditional cognitive behavioral therapies (CBT). In panic disorder and agoraphobia, d-cycloserine results in a quicker response to exposure therapy, though it may not necessarily enhance outcomes.
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