The Standards for Quality Improvement Reporting Excellence (SQUIRE) guidelines provide recommendations for authors reporting on healthcare quality improvement (QI) activities and improvement research. The goals of the guidelines are to increase the breadth and frequency of published reports of QI by encouraging and guiding authors; to improve the utility of QI reports by enhancing their transparency, comprehensiveness, and rigor; and to encourage reflection on the epistemology of QI work. The SQUIRE guidelines can be helpful in describing the evaluation of system-level improvement projects of any size or scope. The developers of SQUIRE proposed that consensus-based publication guidelines might be useful not only to authors in this rapidly developing but inadequately understood area, but also to editors, peer reviewers, and funding agencies. This chapter explains previous versions and current version of the SQUIRE, and summarizes extensions and/or implementations, related activities, development process and evidence of effectiveness of guideline for the SQUIRE.