Central Nervous System Complications of Hepatitis C Virus Infection

Alice Lohrman Andrews Research Professor in Hepatology, Director of Clinical Hepatology, Professor of Internal Medicine, Associate Chair for Clinical Research, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI, USA

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Stephen A. Locarnini MBBS, BSc(Hons), PhD, FRCPath,

Stephen A. Locarnini MBBS, BSc(Hons), PhD, FRCPath

Head, Research & Molecular Development, Victorian Infectious Diseases Reference Laboratory, Melbourne, VIC, Australia

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Arie J. Zuckerman MD, DSc, FRCP, FRCPath, FMedSci,

Arie J. Zuckerman MD, DSc, FRCP, FRCPath, FMedSci

Emeritus Professor of Medical Microbiology, Formerly Principal and Dean, Royal Free Hospital School of Medicine

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First published: 26 July 2013

https://doi.org/10.1002/9781118637272.ch21

Citations: 2

Summary

Chronic hepatitis C virus (HCV) infection is a major cause of liver morbidity, and hepatic encephalopathy is the clearest example of central nervous system (CNS) involvement as a result of virus-induced cirrhosis. However, there is accumulating evidence to suggest a direct effect of HCV infection on CNS function, which can occur at an early stage of chronic infection prior to the development of cirrhosis and unrelated to encephalopathy. In this chapter, we review the current evidence from neuropsychological, brain-imaging, and virological studies that support a direct link between HCV infection and cerebral function and propose a model for HCV infection of the CNS.

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