Chapter 2
Hepatic Immunology
Gyongyi Szabo,
Johanna Bruneau,
Gyongyi Szabo
University of Massachusetts Medical School, Worcester, MA, USA
Search for more papers by this authorJohanna Bruneau
University of Massachusetts Medical School, Worcester, MA, USA
Search for more papers by this authorGyongyi Szabo,
Johanna Bruneau,
Gyongyi Szabo
University of Massachusetts Medical School, Worcester, MA, USA
Search for more papers by this authorJohanna Bruneau
University of Massachusetts Medical School, Worcester, MA, USA
Search for more papers by this authorBook Editor(s):Howard C. Thomas BSc, PhD, FRCP, FRCPath, FMedSci,
Anna S.F. Lok MD,
Stephen A. Locarnini MBBS, BSc(Hons), PhD, FRCPath,
Arie J. Zuckerman MD, DSc, FRCP, FRCPath, FMedSci,
Howard C. Thomas BSc, PhD, FRCP, FRCPath, FMedSci
Emeritus Professor of Hepatology, Department of Medicine, Imperial College London, London, UK
Search for more papers by this authorAnna S.F. Lok MD
Alice Lohrman Andrews Research Professor in Hepatology, Director of Clinical Hepatology, Professor of Internal Medicine, Associate Chair for Clinical Research, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI, USA
Search for more papers by this authorStephen A. Locarnini MBBS, BSc(Hons), PhD, FRCPath
Head, Research & Molecular Development, Victorian Infectious Diseases Reference Laboratory, Melbourne, VIC, Australia
Search for more papers by this authorArie J. Zuckerman MD, DSc, FRCP, FRCPath, FMedSci
Emeritus Professor of Medical Microbiology, Formerly Principal and Dean, Royal Free Hospital School of Medicine
Search for more papers by this authorFirst published: 26 July 2013
Summary
The immune system is an integral part of the liver as an organ. In addition to the classical roles of hepatocytes and biliary cells in metabolism and digestion, the presence of a broad range of immune cells in the liver contributes to its basic functions by sensing and reacting to external and endogenous danger signals. Several unique features characterize immune responses in the liver, including the composition of immune cell types, the local tissue environment that allows close interaction between parenchymal cells and immune cells, and the gut-derived signals arriving from the portal blood. Integration of these components is pivotal for immunological homeostasis in the liver and orchestration of effective immune responses for the protection of the host.
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