This chapter presents a series of case studies with multiple choice questions and answers on endometrial cancer and cervical cancer. It commences with a discourse on combination chemotherapy regimens shown in a phase III randomized trial to result in a superior survival outcome compared to single-agent cisplatin when employed as a component of a chemoradiation strategy in locally advanced cervical cancer. The chapter ends with the chemotherapy procedure in the clinical setting of a 50-year-old female diagnosed with a stage IV endometrial sarcoma. It also discusses on chemotherapy regimen that has been shown to improve overall survival, compared to single-agent cisplatin in metastatic cervical cancer, and the combination of chemotherapy and hormonal therapy in endometrial adenocarcinoma.