Chapter 19
Marine Peptides and Proteins with Cytotoxic and Antitumoral Properties
João Varela,
Catarina Vizetto-Duarte,
Luísa Custódio,
Luísa Barreira,
Fernando Albericio,
João Varela
Centre of Marine Sciences, University of Algarve, Faro, Portugal
Search for more papers by this authorCatarina Vizetto-Duarte
Centre of Marine Sciences, University of Algarve, Faro, Portugal
Search for more papers by this authorLuísa Custódio
Centre of Marine Sciences, University of Algarve, Faro, Portugal
Search for more papers by this authorLuísa Barreira
Centre of Marine Sciences, University of Algarve, Faro, Portugal
Search for more papers by this authorFernando Albericio
Centre of Marine Sciences, University of Algarve, Faro, Portugal
Institute for Research in Biomedicine, Barcelona, Spain; CIBER-BBN, Networking Centre on Bioengineering, Biomaterials and Nanomedicine, Barcelona, Spain
University of Barcelona, Department of Organic Chemistry, Barcelona, Spain
Search for more papers by this authorJoão Varela,
Catarina Vizetto-Duarte,
Luísa Custódio,
Luísa Barreira,
Fernando Albericio,
João Varela
Centre of Marine Sciences, University of Algarve, Faro, Portugal
Search for more papers by this authorCatarina Vizetto-Duarte
Centre of Marine Sciences, University of Algarve, Faro, Portugal
Search for more papers by this authorLuísa Custódio
Centre of Marine Sciences, University of Algarve, Faro, Portugal
Search for more papers by this authorLuísa Barreira
Centre of Marine Sciences, University of Algarve, Faro, Portugal
Search for more papers by this authorFernando Albericio
Centre of Marine Sciences, University of Algarve, Faro, Portugal
Institute for Research in Biomedicine, Barcelona, Spain; CIBER-BBN, Networking Centre on Bioengineering, Biomaterials and Nanomedicine, Barcelona, Spain
University of Barcelona, Department of Organic Chemistry, Barcelona, Spain
Search for more papers by this authorBook Editor(s):Se-Kwon Kim,
Se-Kwon Kim
Marine Bioprocess Research Center, Pukyong National University, Busan, Republic of Korea
Department of Chemistry, Pukyoung National University, Nam-Gu, Busan, Republic of Korea
Search for more papers by this authorFirst published: 27 March 2013
Summary
The wealth of knowledge concerning (poly)peptides with cytotoxic and antitumoral activities that has been gathered in the last 3 decades is astounding. Approval of novel marine peptides for the treatment of oncological patients is very likely to come in the next few years. So far the isolation of marine peptides has had a very limited range of biological sources, but there is a current trend toward widening this search to other taxa, such as fish and nonphotosynthetic bacteria. Moreover, molecular-biology tools such as metagenomics and single-cell genome amplification may soon provide a better understanding of how bioactive peptides are synthesized in nature. The cloning of complete biosynthetic pathways has revealed that bacteria have developed a way to generate an entire collection of peptides by means of cassettes that encode hypervariable amino acid sequences flanked by more conserved regions, which, in turn, recruit modifying enzymes.
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