Chapter 17
Teratogenic Impact of Dioxin Activated AHR in Laboratory Animals†
Barbara D. Abbott,
Barbara D. Abbott
Developmental Biology Branch, Toxicity Assessment Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC, USA
Search for more papers by this authorBarbara D. Abbott,
Barbara D. Abbott
Developmental Biology Branch, Toxicity Assessment Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC, USA
Search for more papers by this authorBook Editor(s):Raimo Pohjanvirta,
Raimo Pohjanvirta
Department of Food Hygiene and Environmental Health, Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland
Search for more papers by this authorFirst published: 10 November 2011
†
This chapter has been reviewed by the National Health and Environmental Effects Research Laboratory, U.S. EPA. The use of trade names is for identification only and does not constitute endorsement by the U.S. EPA.
Summary
This chapter contains sections titled:
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Introduction: AHR-Mediated Developmental Toxicity
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Hydronephrosis: Sensitive Period, Etiology, and Recovery
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Cleft Palate: Sensitive Period and Etiology
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Requirement for AHR Expression in Teratogenic Responses
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Human Palatal AHR Expression and Response in Organ Culture and the Humanized Mouse Model
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AHR and Signaling Pathways: Mechanisms for Teratogenic Responses
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Summary
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References
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