Chapter 17
The Antibiotic Resistome: Origins, Diversity, and Future Prospects
Erin L. Westman, Gerard D. Wright,
Gerard D. Wright
McMaster University, Hamilton, Ontario, Canada
Search for more papers by this authorErin L. Westman, Gerard D. Wright,
Gerard D. Wright
McMaster University, Hamilton, Ontario, Canada
Search for more papers by this authorBook Editor(s):Frans J. de Bruijn,
Frans J. de Bruijn
Laboratory of Plant Micro-organism Interaction, CNRS-INRA, Castanet Tolosan, France
Search for more papers by this authorFirst published: 16 September 2011
Summary
This chapter contains sections titled:
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Introduction
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The Origins of Multidrug Resistance: The Pre-Antibiotic Era
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Expanding the Resistome: Discovery of Modern Resistance Determinants in Diverse Environments
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Acquisition and Recombination of Resistance to Antibiotics and Future Clinical Impact
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Conclusion
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References
REFERENCES
- Abraham EP, Chain E. 1940. An enzyme from bacteria able to destroy penicillin. Rev. Infect. Dis. 10: 677–678.
- Allen HK, Cloud-Hansen KA, Wolinski JM, Guan C, Greene S, et al. 2009a. Resident microbiota of the gypsy moth midgut harbors antibiotic resistance determinants. DNA Cell. Biol. 28: 109–117.
- Allen HK, Moe LA, Rodbumrer J, Gaarder A, Handelsman J. 2009b. Functional metagenomics reveals diverse beta-lactamases in a remote Alaskan soil. ISME J. 3: 243–251.
- Amann RI, Ludwig W, Schleifer KH. 1995. Phylogenetic identification and in situ detection of individual microbial cells without cultivation. Microbiol. Rev. 59: 143–169.
- Ambler RP. 1980. The structure of beta-lactamases. Philos. Trans. R. Soc. Lond. B Biol. Sci. 289: 321–331.
- Barlow M, Hall BG. 2002. Origin and evolution of the AmpC beta-lactamases of Citrobacter freundii. Antimicrob. Agents Chemother. 46: 1190–1198.
- Bauernfeind A, Chong Y, Schweighart S. 1989. Extended broad spectrum beta-lactamase in Klebsiella pneumoniae including resistance to cephamycins. Infection 17: 316–321.
- Benveniste R, Davies J. 1973. Aminoglycoside antibiotic-inactivating enzymes in actinomycetes similar to those present in clinical isolates of antibiotic-resistant bacteria. Proc. Natl. Acad. Sci. USA 70: 2276–2280.
- Brody T, Yavatkar AS, Lin Y, Ross J, Kuzin A, et al. 2008. Horizontal gene transfers link a human MRSA pathogen to contagious bovine mastitis bacteria. PLoS ONE 3: e3074.
- Bunker JP, Frazier HS, Mosteller F. 1994. Improving health: Measuring effects of medical care. Milbank Q. 72: 225–258.
- Cardo D, Horan T, Andrus M, Dembinski M, Edwards J, et al. 2004. National Nosocomial Infections Surveillance (NNIS) System Report, data summary from January 1992 through June 2004, issued October 2004. Am. J. Infect. Control 32: 470–485.
- Cloud-Hansen KA, Villiard KM, Handelsman J, Carey HV. 2007. Thirteen-lined ground squirrels (Spermophilus tridecemlineatus) harbor multiantibiotic-resistant bacteria. J. Am. Assoc. Lab. Anim. Sci. 46: 21–23.
- Cundliffe E. 1989. How antibiotic-producing organisms avoid suicide. Annu. Rev. Microbiol. 43: 207–233.
- D’Costa VM, McGrann KM, Hughes DW, Wright GD. 2006. Sampling the antibiotic resistome. Science 311: 374–377.
- Drummond AJ, Ashton B, Buxton S, Cheung M, Heled J, et al. 2010. Geneious v4.8, Available from http://www.geneious.com.
- Frost LS, Leplae R, Summers AO, Toussaint A. 2005. Mobile genetic elements: The agents of open source evolution. Nat. Rev. Microbiol. 3: 722–732.
- Gerberding J, Gaynes R, Horan T, Alonso-Echanove J, Edwards J, et al. 2000. National Nosocomial Infections Surveillance (NNIS) system report, data summary from January 1992–April 2000, issued June 2000. Am. J. Infect. Control 28: 429–448.
- Gogarten JP, Townsend JP. 2005. Horizontal gene transfer, genome innovation and evolution. Nat. Rev. Microbiol. 3: 679–687.
- Harvey R, Funk J, Wittum TE, Hoet AE. 2009. A metagenomic approach for determining prevalence of tetracycline resistance genes in the fecal flora of conventionally raised feedlot steers and feedlot steers raised without antimicrobials. Am. J. Vet. Res. 70: 198–202.
- Heron M, Hoyert DL, Murphy SL, Xu J, Kochanek KD, et al. 2009. Deaths: Final data for 2006. National Vital Statistics Reports (NVSR) 57: 1–134.
- Huang F, Haydock SF, Mironenko T, Spiteller D, Li Y, et al. 2005. The neomycin biosynthetic gene cluster of Streptomyces fradiae NCIMB 8233: Characterisation of an aminotransferase involved in the formation of 2-deoxystreptamine. Org. Biomol. Chem. 3: 1410–1418.
- Kazimierczak KA, Rincon MT, Patterson AJ, Martin JC, Young P, et al. 2008. A new tetracycline efflux gene, tet(40), is located in tandem with tet(O/32/O) in a human gut firmicute bacterium and in metagenomic library clones. Antimicrob. Agents Chemother. 52: 4001–4009.
- Kazimierczak KA, Scott KP, Kelly D, Aminov RI. 2009. Tetracycline resistome of the organic pig gut. Appl. Environ. Microbiol. 75: 1717–1722.
- Kieser T, Bib MJ, Buttner MJ, Chater KF. 2000. Practical Streptomyces Genetics. Norwich, CT: The John Innes Foundation.
- Martinez JL, Baquero F, Andersson DI. 2007. Predicting antibiotic resistance. Nat. Rev. Microbiol. 5: 958–965.
- Mori T, Mizuta S, Suenaga H, Miyazaki K. 2008a. Metagenomic screening for bleomycin resistance genes. Appl. Environ. Microbiol. 74: 6803–6805.
- Mori T, Suenaga H, Miyazaki K. 2008b. A metagenomic approach to the identification of UDP-glucose 4-epimerase as a menadione resistance protein. Biosci. Biotechnol. Biochem. 72: 1611–1614.
- Nordmann P. 1998. Trends in beta-lactam resistance among Enterobacteriaceae. Clin. Infect. Dis. 27(Suppl 1): S100–S106.
- Pallecchi L, Riccobono E, Mantella A, Bartalesi F, Sennati S, et al. 2009a. High prevalence of qnr genes in commensal enterobacteria from healthy children in Peru and Bolivia. Antimicrob. Agents Chemother. 53: 2632–2635.
- Pallecchi L, Riccobono E, Sennati S, Mantella A, Bartalesi F, et al. 2010. Characterization of small ColE-like plasmids mediating widespread dissemination of the qnrB19 gene in commensal Enterobacteria. Antimicrob. Agents Chemother. 54: 678–682.
- Phillips I, Casewell M, Cox T, De Groot B, Friis C, et al. 2004. Does the use of antibiotics in food animals pose a risk to human health? A critical review of published data. J. Antimicrob. Chemother. 53: 28–52.
- Pootoolal J, Thomas MG, Marshall CG, Neu JM, Hubbard BK, et al. 2002. Assembling the glycopeptide antibiotic scaffold: The biosynthesis of A47934 from Streptomyces toyocaensis NRRL15009. Proc. Natl. Acad. Sci. USA 99: 8962–8967.
- Riesenfeld CS, Goodman RM, Handelsman J. 2004. Uncultured soil bacteria are a reservoir of new antibiotic resistance genes. Environ. Microbiol. 6: 981–989.
- Roberts MC. 1998. Antibiotic resistance in oral/respiratory bacteria. Crit. Rev. Oral Biol. Med. 9: 522–540.
- Sanchez MB, Hernandez A, Rodriguez-Martinez JM, Martinez-Martinez L, Martinez JL. 2008. Predictive analysis of transmissible quinolone resistance indicates Stenotrophomonas maltophilia as a potential source of a novel family of Qnr determinants. BMC Micro-biol. 8: 148.
- Seville LA, Patterson AJ, Scott KP, Mullany P, Quail MA, et al. 2009. Distribution of tetracycline and erythromycin resistance genes among human oral and fecal metagenomic DNA. Microb. Drug Resist. 15: 159–166.
- Sommer MO, Dantas G, Church GM. 2009. Functional characterization of the antibiotic resistance reservoir in the human microflora. Science 325: 1128–1131.
- Song JS, Jeon JH, Lee JH, Jeong SH, Jeong BC, et al. 2005. Molecular characterization of TEM-type beta-lactamases identified in cold-seep sediments of Edison Seamount (south of Lihir Island, Papua New Guinea). J. Microbiol. 43: 172–178.
- Thaker M, Spanogiannopoulos P, Wright GD. 2010. The tetracycline resistome. Cell. Mol. Life Sci. 67: 419–431.
- Villedieu A, Diaz-Torres ML, Hunt N, McNab R, Spratt DA, et al. 2003. Prevalence of tetracycline resistance genes in oral bacteria. Antimicrob. Agents Chemother. 47: 878–882.
- Villedieu A, Diaz-Torres ML, Roberts AP, Hunt N, McNab R, et al. 2004. Genetic basis of erythromycin resistance in oral bacteria. Antimicrob. Agents Chemother. 48: 2298–2301.
- Warburton P, Roberts AP, Allan E, Seville L, Lancaster H, etal. 2009. Characterization of tet(32) genes from the oral metagenome. Antimicrob. Agents Chemother. 53: 273–276.
- Wright GD. 2007. The antibiotic resistome: The nexus of chemical and genetic diversity. Nat. Rev. Microbiol. 5: 175–186.
- Yung PY, Burke C, Lewis M, Egan S, Kjelleberg S, et al. 2009. Phylogenetic screening of a bacterial, metagenomic library using homing endonuclease restriction and marker insertion. Nucleic Acids Res. 37: e144.
