Chapter 4
Noninvasive Imaging of the Biliary System
Elmar M. Merkle,
Rendon C. Nelson,
He Nrik Petrowsky,
Elmar M. Merkle
Search for more papers by this authorRendon C. Nelson
Search for more papers by this authorHe Nrik Petrowsky
Search for more papers by this authorElmar M. Merkle,
Rendon C. Nelson,
He Nrik Petrowsky,
Elmar M. Merkle
Search for more papers by this authorRendon C. Nelson
Search for more papers by this authorHe Nrik Petrowsky
Search for more papers by this authorBook Editor(s):Pierre-Alain Clavien MD, PhD, FACS, FRCS,
John Baillie MB, ChB, FRCP, FACG,
Pierre-Alain Clavien MD, PhD, FACS, FRCS
Professor and Chairman, Swiss Hepato-Pancreato-Biliary Center, Department of Visceral and Transplant Surgery, University Hospital Zurich, Zurich, Switzerland
Search for more papers by this authorJohn Baillie MB, ChB, FRCP, FACG
Professor of Medicine, Director of Hepatobiliary and Pancreatic Disorder Service, Wake Forest University Health Sciences Center, Winston-Salem, North Carolina, USA
Search for more papers by this authorFirst published: 14 June 2006
Summary
This chapter contains sections titled:
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Introduction
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Spectrum of cross-sectional imaging modalities
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Gallbladder
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Bile ducts
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Cholescintigraphy
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Questions
References
- Harisinghani MG, Saini S, Schima W, et al. Simethicone coated cellulose as an oral contrast agent for ultrasound of the upper abdomen. Clin Radiol 1997; 52: 224–6.
- Kono Y, Moriyasu F, Nada T, et al. Grayscale second harmonic imaging of the liver: a preliminary animal study. Ultrasound Med Biol 1997; 23: 719–26.
- Ortega D, Burns PN, Hope Simpson D, Wilson SR. Tissue harmonic imaging: is it a benefit for bile duct sonography? Am J Roentgenol 2001; 176: 653–9.
- Wilson SR, Burns PN, Muradali D, et al. Harmonic hepatic US with microbubble contrast agent: initial experience showing improved characterization of hemangioma, hepatocellular carcinoma, and metastasis. Radiology 2000; 215: 153–61.
- Loyer EM, Chin H, Du Brow RA, et al. Hepatocellular carcinoma and intrahepatic peripheral cholangiocarcinoma: enhancement patterns with quadruple phase helical CT—a comparative study. Radiology 1999; 212: 866–75.
- McNulty NJ, Francis I R, Platt J F, et al. Multi-detector row helical CT of the pancreas: effect of contrast-enhanced multiphasic imaging on enhancement of the panc reas, per ipanc reatic vas-culature, and pancreatic adenocarcinoma. Radiology 2001; 220: 97–102.
- de Bazelaire CM, Duhamel GD, Rofsky NM, Alsop DC. MR imaging relaxation times of abdominal and pelvic tissues measured in vivo at 3.0 T: preliminary results. Radiology 2004; 230: 652–9.
- Van Beers BE, Gallez B, Pringot J. Contrast-enhanced MR imaging of the liver. Radiology 1997; 203: 297–306.
- Prince MR, Arnoldus C, Frisoli JK. Nephrotoxicity of high-dose gadolinium compared with iodinated contrast. J Magn Reson Imaging 1996; 6: 162–6.
- Wallner BK, Schumacher KA, Weidenmaier W, Friedrich JM. Dilated biliary tract: evaluation with MR cholangiography with a T2-weighted contrast-enhanced fast sequence. Radiology 1991; 181: 805–8.
- Lee VS, Krinsky GA, Nazzaro CA, et al. Defining intrahepatic biliary anatomy in living liver transplant donor candidates at mangafodipir trisodium-enhanced MR cholangiography versus conventional T2-weighted MR cholangiography. Radiology 2004; 233: 659–66.
- Reimer P, Schneider G, Schima W. Hepatobiliary contrast agents for contrast-enhanced MRI of the liver: properties, clinical development and applications. Eur Radiol 2004; 14: 559–78.
- Warburg O, Neglers E. On the metabolism of tumors in the body. London: Consable, 1930.
- Hany TF, Steinert HC, Goerres GW, et al. PET diagnostic accuracy: improvement with in-line PET-CT system: initial results. Radiology 2002; 225: 575–81.
- Perkerson RB, Jr, Erwin BC, Baumgartner BR, et al. CT densities in delayed iodine hepatic scanning. Radiology 1985; 155: 445–6.
- Adusumilli S, Siegelman ES. MR imaging of the gallbladder. Magn Reson Imaging Clin N Am 2002; 10: 165–84.
- Prescot AP, Collins DJ, Leach MO, Dzik-Jurasz AS. Human gallbladder bile: noninvasive investigation in vivo with single-voxel 1H MR spectroscopy. Radiology 2003; 229: 587–92.
- McIntosh DM, Penney HF. Gray-scale ultrasonography as a screening procedure in the detection of gallbladder disease. Radiology 1980; 136: 725–7.
- Birnholz JC. Population survey: ultrasonic cholecystography. Gastrointest Radiol 1982; 7: 165–7.
- Havrilla TR, Reich NE, Haaga JR, et al. Computed tomography of the gallbladder. Am J Roentgenol 1978; 130: 1059–67.
- Barakos JA, Ralls PW, Lapin SA, et al. Cholelithiasis: evaluation with CT. Radiology 1987; 162: 415–8.
- Park MS, Yu JS, Kim YH, et al. Acute cholecystitis: comparison of MR cholangiography and US. Radiology 1998; 209: 781–5.
- Ralls PW, Colletti PM, Halls JM, Siemsen JK. Prospective evaluation of 99mTc-IDA cholescintigraphy and gray-scale ultrasound in the diagnosis of acute cholecystitis. Radiology 1982; 144: 369–71.
- Ralls PW, Colletti PM, Lapin SA, et al. Real-time sonography in suspected acute cholecystitis. Prospective evaluation of primary and secondary signs. Radiology 1985; 155: 767–71.
- Laing FC, Federle M P, Jeffrey RB, Brown TW. Ultrasonic evaluation of patients with acute right upper quadrant pain. Radiology 1981; 140: 449–55.
- Soyer P, Brouland JP, Boudiaf M, et al. Color velocity imaging and power Doppler sonography of the gallbladder wall: a new look at sonographic diagnosis of acute cholecystitis. Am J Roentgenol 1998; 171: 183–8.
- Uggowitzer M, Kugler C, Schramayer G, et al. Sonography of acute cholecystitis: comparison of color and power Doppler so-nography in detecting a hypervascularized gallbladder wall. Am J Roentgenol 1997; 168: 707–12.
- Paulson EK, Kliewer MA, Hertzberg BS, et al. Diagnosis of acute cholecystitis with color Doppler sonography: signifi-cance of arterial fl ow in thickened gallbladder wall. Am J Roentgenol 1994; 162: 1105–8.
- Regan F, Schaefer DC, Smith DP, et al. The diagnostic utility of HASTEMRI in the eva luation of acute cholecystitis. Half-Fourier acquisition single-shot turbo SE. J Comput Assist Tomogr 1998; 22: 638–42.
- Loud PA, Semelka RC, Kettritz U, et al. MRI of acute cholecystitis: comparison with the normal gallbladder and other entities. Magn Reson I maging 1996; 14: 349–55.
- Demachi H, Matsui O, Hoshiba K, et al. Dynamic MRI using a surface coil in chronic cholecystitis and gallbladder carcinoma: radiologic and histopathologic correlation. J Comput Assist Tomogr 1997; 21: 643–51.
- Vaittinen E. Carcinoma of the gallbladder. A study of 390 cases diagnosed in Finland 1953–1967. Ann Chir Gy naecol Fenn Suppl 1970; 168: 1–81.
- Ito H, Matros E, Brooks DC, et al. Treatment outcomes associated with surgery for gallbladder cancer: a 20-year experience. J Gastrointest Surg 2004; 8: 183–90.
- Hart J, Modan B, Hashomer T. Factors affecting survival of patients with gallbladder neoplasms. Arch Intern Med 1972; 129: 931–4.
- Bach AM, Loring LA, Hann LE, et al. Gallbladder cancer: can ultrasonography evaluate extent of disease? J Ultrasound Med 1998; 17: 303–9.
- Ohtani T, Shirai Y, Tsukada K, et al. Spread of gallbladder carcinoma: CT evaluation with pathologic correlation. Abdom Imaging 1996; 21: 195–201.
- Rooholamini SA, Tehrani NS, Razavi MK, et al. Imaging of gallbladder carcinoma. Radiographics 1994; 14: 291–306.
- Sagoh T, Itoh K, Togashi K, et al. Gallbladder carcinoma: evaluation with MR imaging. Radiology 1990; 174: 131–6.
- Schwartz LH, Black J, Fong Y, et al. Gallbladder carcinoma: findings at MR imaging with MR cholangiopancreatography. J Comput Assist Tomogr 2002; 26: 405–10.
- Koh T, Taniguchi H, Yamaguchi A, et al. Differential diagnosis of gallbladder cancer using positron emission tomography with fluorine-18-labeled fluoro-deoxyglucose (FDG-PET). J Surg Oncol 2003; 84: 74–81.
- Anderson CD, Rice MH, Pinson CW, et al. Fluorodeoxyg lucose PET imaging in the evaluation of gallbladder carcinoma and cholangiocarcinoma. J Gastrointest Surg 2004; 8: 90–7.
- Rodriguez-Fernandez A, Gomez-Rio M, Llamas-Elvira JM, et al. Positron-emission tomography with fl uorine-18-fl uoro-2-deoxy-D-glucose for gallbladder cancer diagnosis. Am J Surg 2004; 188: 171–5.
- Petrowsky H, Wildbrett P, Husarik D, et al. Impact of integrated position emission tomography and computed tomography on staging and management of gallbladder cancer and cholangio-carcinoma. (submitted for publication).
- Caoili EM, Paulson EK, Heyneman LE, et al. Helical CT chol-angiography with three-dimensional volume rendering using an oral biliary contrast agent: feasibility of a novel technique. Am J Roentgenol 2000; 174: 487–92.
- Yeh BM, Breiman RS, Taouli B, et al. Biliary tract depiction in living potential liver donors: comparison of conventiona IMR, mangafodipir trisodium-enhanced excretory MR, and multi-detector row CT cholangiography - initial experience. R ad iol-ogy 2004; 230: 645–51.
-
Coakley FV,
Schwartz LH.
Magnetic resonance cholangiopancreatography.
J Magn Reson Imaging
1999;
9: 157–62.
10.1002/(SICI)1522-2586(199902)9:2<157::AID-JMRI2>3.0.CO;2-N CAS PubMed Web of Science® Google Scholar
- Takehara Y. Can MRCP replace ERCP? J Magn Reson Imaging 1998; 8: 517–34.
- Barish MA, Soto JA, Yucel EK. Magnetic resonance cholangio-pancreatography of the biliary ducts: techniques, clinical applications, and limitations. Top Magn Reson Imaging 1996; 8: 302–11.
- Van Hoe L, Mermuys K, Vanhoenacker P. MRCP pitfalls. Abdom Imaging 2004; 29: 360–87.
- Reinhold C, Guibaud L, Genin G, Bret PM. MR cholangiopancreatography: comparison between two-dimensional fast spin-echo and three-dimensional gradient-echo pulse sequences. J Magn Reson Imaging 1995; 5: 379–84.
- Vyas PK, Vesy TL, Konez O, et al. Estimation of gallbladder ejection fraction utilizing cholecystokinin-stimulated magnetic resonance cholangiography and comparison with hepatobiliary scintigraphy. J Magn Reson Imaging 2002; 15: 75–81.
- Bowie JD. What is the upper limit of normal for the common bile duct on ultrasound: how much do you want it to be? Am J Gastroenterol 2000; 95: 897–900.
- Mitchell SE, Clark RA. A comparison of computed tomography and sonography in choledocholithiasis. Am J Roentgenol 1984; 142: 729–33.
- Jeffrey R B, Federle M P, Laing FC, et al. Computed tomography of choledocholithiasis. Am J Roentgenol 1983; 140: 1179–83.
- Pickuth D, Spielmann RP. Detection of choledocholithiasis: comparison of unenhanced spiral CT, US, and ERCP. Hepato-gastroenterology 2000; 47: 1514–7.
- Neitlich JD, Topazian M, Smith RC, et al. Detection of choledo-cholithiasis: comparison of unenhanced helical CT and endoscopic retrograde cholangiopancreatography. Radiology 1997; 203: 753–7.
- Lui WY, Chau GY, Wu CW, King KL. Surgical resection of hepatocellular carcinoma in elderly cirrhotic patients. Hepato-gastroenterology 1999; 46: 640–5.
- Varghese JC, Farrell MA, Courtney G, et al. A prospective comparison of magnetic resonance cholangiopancreatography with endoscopic retrograde cholangiopancreatography in the evaluation of patients with suspected biliary tract disease. Clin Radiol 1999; 54: 513–20.
- Reinhold C, Taourel P, Bret PM, et al. Choledocholithiasis: evaluation of MR cholangiography for diagnosis. Radiology 1998; 209: 435–42.
- Dwerryhouse SJ, Brown E, Vipond MN. Prospective evaluation of magnetic resonance cholangiography to detect common bile duct stones before laparoscopic cholec ystectomy. Br J Surg 1998; 85: 1364–6.
- Chan YL, Chan AC, Lam WW, et al. Choledocholithiasis: comparison of MR cholangiography and endoscopic retrograde cholangiography. Radiology 1996; 200: 85–9.
- Romagnuolo J, Bardou M, Rahme E, et al. Mag netic resonance cholangiopancreatography: a meta-analysis of test performance in suspected biliary disease. Ann Intern Med 2003; 139: 547–57.
- Chan FL, Man SW, Leong LL, Fan ST. Evaluation of recurrent pyogenic cholangitis with CT: analysis of 50 patients. Radiology 1989; 170: 165–9.
- Bader T R, Braga L, Beavers K L, Semelka RC. MR imaging findings of infectious cholangitis. Magn Reson Imaging 2001; 19: 781–8.
- Wiesner RH, Ludwig J, LaRusso NF, MacCarty RL. Diagnosis and treatment of primary sclerosing cholangitis. Semin Liver Dis 1985; 5: 241–53.
- MacCarty RL, LaRusso NF, May GR, et al. Cholangiocarcinoma complicating primary sclerosing cholangitis: cholangiographic appearances. Radiology 1985; 156: 43–6.
- Dodd GD, 3rd, Niedzwiecki GA, Campbell WL, Baron RL. Bile duct calculi in patients with primary sclerosing cholangitis. Radiology 1997; 203: 443–7.
- Textor HJ, Flacke S, Pauleit D, et al. Three-dimensional magnetic resonance cholangiopancreatography with respiratory triggering in the diagnosis of primary sclerosing cholangitis: comparison with endoscopic retrograde cholangiography. En-doscopy 2002; 34: 984–90.
- Ito K, Mitchell DG, Outwater EK, Blasbalg R. Primary sclerosing cholangitis: MR imaging features. Am J Roentgenol 1999; 172: 1527–33.
- Fulcher AS, Turner MA, Franklin KJ, et al. Primary sclerosing cholangitis: evaluation with MR cholangiography — a case-control study. Radiology 2000; 215: 71–80.
- Alonso-Lej F, Rever WB, Jr, Pessagno DJ. Congenital choledochal cyst, with a report of 2, and an analysis of 94, cases. Int Abstr Surg 1959; 108: 1–30.
- Todani T, Watanabe Y, Narusue M, et al. Congenital bile duct cysts: Classification, operative procedures, and review of thirty-seven cases including cancer arising from choledochal cyst. Am J Surg 1977; 134: 263–9.
- Crittenden SL, McKinley M J. Choledochal cyst - clinical features and classification. Am J Gastroenterol 1985; 80: 643–7.
- Voyles CR, Smadja C, Shands WC, Blumgart LH. Carcinoma in choledochal cysts. Age-related incidence. Arch Surg 1983; 118: 986–8.
- Reuter K, Raptopoulos VD, Cantelmo N, et al. The diagnosis of a choledochal cyst by ultrasound. Radiology 1980; 136: 437–8.
- Araki T, Itai Y, Tasaka A. CT of choledochalcyst. Am J Roent-genol 1980; 135: 729–34.
- Matos C, Nicaise N, Deviere J, et al. Choledochal cysts: comparison of findings at MR cholangiopancreatography and endoscopic retrograde cholangiopancreatography in eight patients. Radiology 1998; 209: 443–8.
- Irie H, Honda H, Jimi M, et al. Value of MR cholangiopancreatography in evaluating choledochal cysts. Am J Roentgenol 1998; 171: 1381–5.
- Pavone P, Laghi A, Catalano C, et al. Caroli's disease: evaluation with MR cholangiopancreatography (MRCP). Abdom Imaging 1996; 21: 117–9.
- Lavine E, Maklad MF, Wright CH, Lee KR. Computed tomography and ultrsonic appearances of primary carcinoma of the common bile duct. Gastrointest Radiol 1979; 4: 147–51.
- Farley DR, Weaver AL, Nagorney DM. “Natural history” of unresected cholangiocarcinoma: patient outcome after noncurative intervention. Mayo Clin Proc 1995; 70: 425–9.
- Soyer P, Bluemke DA, Reichle R, et al. Imaging of intrahepatic cholangiocarcinoma: 2. Hilar cholangiocarcinoma. Am J Roentgenol 1995; 165: 1433–6.
- Soyer P, Bluemke DA, Reichle R, et al. Imaging of intrahepatic cholangiocarcinoma: 1. Peripheral cholangiocarcinoma. Am J Roentgenol 1995; 165: 1427–31.
- Otto G, Romaneehsen B, Hoppe-Lotichius M, Bittinger F. Hilar cholangiocarcinoma: resectability and radicality after routine diagnostic imaging. J Hepatobiliary Pancreat Surg 2004; 11: 310–8.
- Subramanyam BR, Raghavendra BN, Balthazar EJ, et al. Ultrasonic features of cholangiocarcinoma. J Ultrasound Med 1984; 3: 405–8.
- Choi BI, Lee JH, Han MC, et al. Hilar cholangiocarcinoma: comparative study with sonography and CT. Radiology 1989; 172: 689–92.
- Vazquez JL, Thorsen MK, Dodds WJ, et al. Atrophy of the left hepatic lobe caused by a cholangiocarcinoma. Am J Roentgen-ol 1985; 144: 547–8.
- Keogan MT, Seabourn JT, Paulson EK, et al. Contrast-enhanced CT of intrahepatic and hilar cholangiocarcinoma: delay time for optimal imaging. Am J Roentgenol 1997; 169: 1493–9.
- Choi BI, Han JK, Shin YM, et al. Peripheral cholangiocarcinoma: comparison of MRI with CT. Abdom Imaging 1995; 20: 357–60.
- Soyer P, Bluemke DA, Sibert A, Laissy J P. MR imaging of intrahepatic cholangiocarcinoma. Abdom Imaging 1995; 20: 126–30.
- Adjei ON, Tamura S, Sugimura H, et al. Contrast-enhanced MR imaging of intrahepatic cholangiocarcinoma. Clin Radiol 1995; 50: 6–10.
- Kim YJ, Yun M, Lee WJ, et al. Usefulness of 18F-FDG PET in intrahepatic cholangiocarcinoma. Eur J Nucl Med Mol Imaging 2003; 30: 1467–72.
- Kluge R, Schmidt F, Caca K, et al. Positron emission tomography with [(18)F]fluoro-2-deoxy-D-glucose for diagnosis and staging of bile duct cancer. Hepatology 2001; 33: 1029–35.
- Carr TG, Kazarian KK, Smego DR, Barone JE. Radionuclide cholescintigraphy in patients with suspected biliary tract obstruction. Am Surg 1991; 57: 673–5.
- Lecklitner M L, Austin A R, Benedetto A R, Growcock GW. Positive predictive value of cholescintigraphy in common bile duct obstruction. J Nucl Med 1986; 27: 1403–6.
- Toftdahl DB, Hojgaard L, Winkler K. Dynamic cholescintigraphy: induction and description of gallbladder emptying. J Nucl Med 1996; 37: 261–6.
- Kim CK, Palestro CJ, Solomon RW, et al. Delayed biliary-to-bowel transit in cholescintigraphy after cholecystokinin treatment. Radiology 1990; 176: 553–6.
- Kim CK, Lim JK, Machac J. Variable bile retention on choles-cintigraphy after morphine administration. Eur J Nucl Med 1996; 23: 1464–7.
- Flancbaum L, Choban PS, Sinha R, Jonasson O. Morphine cholescintigraphy in the evaluation of hospitalized patients with suspected acute cholecystitis. Ann Surg 1994; 220: 25–31.
- Adam A, Roddie ME. Acute cholecystitis: radiological management. Baillieres Clin Gastroenterol 1991; 5: 787–816.
- Lauritsen KB, Sommer W, Hahn L, Henriksen JH. Choles-cintigraphy and ultrasonography in patients suspected of having acute cholecystitis. Scand J Gastroenterol 1988; 23: 42–6.
- Krishnamurthy S, Krishnamurthy GT. Cholecystokinin and morphine pharmacological intervention during 99mTc-HIDA cholescintigraphy: a rational approach. Semin Nucl Med 1996; 26: 16–24.
- Kim CK. Pharmacologic intervention for the diag nosis of acute cholecystitis: cholecystokinin pretreatment or morphine, or both? J Nucl Med 1997; 38: 647–9.
- Bohdiewicz PJ. The diagnostic value of grading hyperperfu-sion and the rim sign in cholescintigraphy. Clin Nucl Med 1993; 18: 867–71.
- Klingensmith WC 3rd, Turner WM. Cholescintigraphy for acute cholecystitis: false positive results caused by chronic cholecystitis. Gastrointest Radiol 1990; 15: 129–32.
- Nadel H R. Hepatobiliary scintigraphy in children. Semin Nucl Med 1996; 26: 25–42.
- Cox K L, Stadalnik RC, McGahan J P, et al. Hepatobiliary scintigraphy with technetium-99m disofenin in the evaluation of neonatal cholestasis. J Pediatr Gastroenterol Nutr 1987; 6: 885–91.
- Krishnamurthy S, Krishnamurthy GT. Biliary dyskinesia: role of the sphincter of Oddi, gallbladder and cholecystokinin. J Nucl Med 1997; 38: 1824–30.
- Sorenson M K, Fancher S, Lang NP, et al. Abnormal gallbladder nuclear ejection fraction predicts success of cholecystectomy in patients with biliary dyskinesia. Am J Surg 1993; 166: 672–4; discussion 4–5.
- Fritscher-Ravens A, Bohuslavizki KH, Broering DC, et al. FDG PET in the diagnosis of hilar cholangiocarcinoma. Nucl Med Commun 2001; 22: 1277–85.
- Kato T, Tsukamoto E, Kuge Y, et al. Clinical role of (18)F-FDG PET for initial staging of patients with extrahepatic bile duct cancer. Eur J Nucl Med Mol Imaging 2002; 29: 1047–54.