Chapter 20.8
The Liver in Graft-vs.-Host Disease
Enric Carreras,
Carmen Martínez,
Miguel Bruguera,
Enric Carreras
Search for more papers by this authorCarmen Martínez
Search for more papers by this authorMiguel Bruguera
Search for more papers by this authorEnric Carreras,
Carmen Martínez,
Miguel Bruguera,
Enric Carreras
Search for more papers by this authorCarmen Martínez
Search for more papers by this authorMiguel Bruguera
Search for more papers by this authorBook Editor(s):Juan Rodés MD,
Jean-Pierre Benhamou MD,
Andres T. Blei MD,
Jürg Reichen MD,
Mario Rizzetto MD,
Juan Rodés MD
Director General, Hospital Clinic; Professor of Medicine, University of Barcelona, Barcelona, Spain
Search for more papers by this authorJean-Pierre Benhamou MD
Professor of Hepatology, Université Denis Diderot Paris 7, Assistance Publique — Hôpitaux de Paris and Inserm U773, Service d'Hépatologie, Hôpital Beaujon, Clichy, France
Search for more papers by this authorAndres T. Blei MD
Professor of Medicine and Surgery, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA
Search for more papers by this authorJürg Reichen MD
Professor of Medicine, University of Bern; Chief of Hepatology, University Hospital, Bern, Switzerland
Search for more papers by this authorMario Rizzetto MD
Professor of Gastroenterology, University of Turin, Turin, Italy
Search for more papers by this author
References
- Ferrara JL, Deeg HJ (1991) Graft-versus-host disease. N Engl J Med 7, 667–674.
- Ferrara JL, Cooke KR, Teshima T (2003) The pathophysiology of acute graft-versus-host disease. Int J Hematol 78, 181–187.
- Ferrara JLM, Antin JH (1999) The pathophysiology of graft-versus-host. In: ED Thomas KG Blume SJ Forman (eds) Hematopoietic Cell Transplantation, 2nd edn. Cambridge, MA: Blackwell Science, pp. 305–315.
- Sullivan KM (1999) Graft-versus-host disease. In: ED Thomas KG Blume SJ Forman (eds) Hematopoietic Cell Transplantation, 2nd edn. Cambridge, MA: Blackwell Science, pp. 515–536.
- Urbano-Ispizua A Brunet S Solano C et al. (2001) Allogeneic transplantation of CD34+-selected cells from peripheral blood in patients with myeloid malignancies in early phase: a case control comparison with unmodified peripheral blood transplantation. Bone Marrow Transplant 28, 349–354.
- Lowsky R, Takahashi T, Liu YP et al. (2005) Protective conditioning for acute graft-versus-host disease. N Engl J Med 353, 1321–1331.
- Pérez-Simón JA Díez-Campelo M Martino R et al. (2005) Influence of the intensity of the conditioning regimen on the characteristics of acute and chronic graft-versus-host disease after allogeneic transplantation. Br J Haematol 130, 394–403.
- Ma SY, Au WY, Lie AK et al. (2004) Liver graft-versus-host disease after donor lymphocyte infusion for relapses of hematologic malignancies post allogeneic hematopoietic stem cell transplantation. Bone Marrow Transplant 34, 57–61.
- Johnson BD, Truitt RL (1995) Delayed infusion of immunocompetent donor cells after bone marrow transplantation breaks graft-host tolerance allows for persistent antileukemic reactivity without severe graft-versus-host disease. Blood 85, 3302–3312.
- Hill GR, Ferrara JL (2000) The primacy of the gastrointestinal tract as a target organ of acute graft-versus-host disease: rationale for the use of cytokine shields in allogeneic bone marrow transplantation. Blood 95, 2754–2759.
- Bierer BE, Hollander G, Fruman D et al. (1993) Cyclosporin A and FK506: molecular mechanisms of immunosuppression and probes for transplantation biology. Curr Opin Immunol 5, 763–773.
- Belanger C Esperou-Bourdeau H Bordigoni P et al. (1993) Use of an anti-interleukin-2 receptor monoclonal antibody for GVHD prophylaxis in unrelated donor BMT. Bone Marrow Transplant 11, 293–297.
- Kagi D, Vignaux F, Ledermann B et al. (1994) Fas and perforin pathways as major mechanisms of T cell-mediated cytotoxicity. Science 265, 528–530.
- Graubert TA, DiPersio JF, Russell JH et al. (1997) Perforin/granzyme-dependent and independent mechanisms are both important for the development of graft-versus-host disease after murine bone marrow transplantation. J Clin Invest 100, 904–911.
- Schmaltz C, Alpdogan O, Muriglan SJ et al. (2003) Donor T cell-derived TNF is required for graft-versus-host disease and graft-versus-tumor activity after bone marrow transplantation. Blood 101, 2440–2445.
- Cooke KR, Hill GR, Gerbitz A et al. (2000) Tumor necrosis factor-alpha neutralization reduces lung injury after experimental allogeneic bone marrow transplantation. Transplantation 70, 272–279.
- Johnson BD, Konkol MC, Truitt RL (2002) CD25+ immunoregu-latory T-cells of donor origin suppress alloreactivity after BMT. Biol BloodMarrow Transplant 8, 525–535.
- Zhang Y, Shlomchik WD, Joe G et al. (2002) APCs in the liver and spleen recruit activated allogeneic CD8+ T cells to elicit hepatic graft-versus-host disease. J Immunol 169, 7111–7118.
- Murai M, Yoneyama H, Harada, A. et al. (1999) Active participation of CCR5(+)CD8(+) T lymphocytes in the pathogenesis of liver injury in graft-versus-host disease. J Clin Invest 104, 49–57.
- Ichiba T, Teshima T, Kuick R et al. (2003) Early changes in gene expression profiles of hepatic GVHD uncovered by oligonucleotide microarrays. Blood 102, 763–771.
- Ueno Y, Ishii M, Yahagi K et al. (2000) Fas-mediated cholangiopathy in the murine model of graft versus host disease. Hepatology 4, 966–974.
- Hattori K, Hirano T, Miyajima H et al. (1998) Differential effects of anti-Fas ligand and anti-tumor necrosis factor alpha antibodies on acute graft-versus-host disease pathologies. Blood 91, 4051–4055.
- Strasser SI, McDonald GB (2003) Hepatobiliary complications of hematopoietic cell transplantation. In: ER Shiff MF Sorrell WC Maddrey (eds) Schiffs Diseases of the Liver, 9th edn. Philadelphia, PA: Lippincott, pp. 1635–1663.
- Akpek G, Boitnott JK, Lee LA et al. (2002) Hepatitic variant of graft-versus-host disease after donor lymphocyte infusion. Blood 100, 3903–3907.
- Fujii N, Takenaka K, Shinagawa K et al. (2001) Hepatic graft-versus-host disease presenting as an acute hepatitis after allogeneic peripheral blood stem cell transplantation. Bone Marrow Transplant 27, 1007–1010.
- Sale GE, Shulman HM, Hackman RC (1999) Pathology of hematopoietic cell transplantation. In: ED Thomas KG Blume SJ Forman (eds) Hematopoietic Cell Transplantation, 2nd edn. Cambridge, MA: Blackwell Science, pp. 248–263.
- Strasser SI, Shulman HM, Flowers ME et al. (2000) Chronic graft-versus-host disease of the liver: presentation as an acute hepatitis. Hepatology 32, 1265–1271.
- Duarte RF, Delgado J, Shaw BE et al. (2005) Histologic features of the liver biopsy predict the clinical outcome for patients with graft-versus-host disease of the liver. Biol Blood Marrow Transplant 10, 805–813.
- Martin PJ, Schoch G, Fisher L et al. (1990) A retrospective analysis of therapy for acute graft-versus-host disease: initial treatment. Blood 76, 1464–1472.
- Martin PJ, Schoch G, Fisher L et al. (1991) A retrospective analysis of therapy for acute graft-versus-host disease: secondary treatment. Blood 77, 1821–1828.
- Lee SJ, Vogelsang G, Flowers ME (2003) Chronic graft-versus-host disease. Biol Blood Marrow Transplant 9, 215–233.
- Komanduri KV (2002) Thymic function and allogeneic T-cell responses in stem-cell transplantation. Cytotherapy 4, 333–342.
- Atkinson K, Horowitz MM, Gale RP et al. (1990) Risk factors for chronic graft-versus-host disease after HLA-identical sibling bone marrow transplantation. Blood 75, 2459–2464.
- Ochs LA, Miller WJ, Filipovich AH et al. (1994) Predictive factors for chronic graft-versus-host disease after histocompatible sibling donor bone marrow transplantation. Bone Marrow Transplant 13, 455–460.
- Akpek G, Zahurak ML, Piantadosi S et al. (2001) Development of a prognostic model for grading chronic graft-versus-host disease. Blood 97, 1219–1226.
- Loughran TP Jr Sullivan K Morton T et al. (1990) Value of day 100 screening studies for predicting the development of chronic graft-versus-host disease after allogeneic bone marrow transplantation. Blood 76, 228–234.
- Akpek G, Lee SJ, Flowers ME et al. (2003). Performance of a new clinical grading system for chronic graft-versus-host disease: a multi-center study. Blood 102, 802–809.
- Strasser SI, Sullivan KM, Myerson D et al. (1999) Cirrhosis of the liver in long-term marrow transplant survivors. Blood 93, 3259–3266.
- Shulman HM, Sharma P, Amos D et al. (1988) A coded histologic study of hepatic graft-versus-host disease after human bone marrow transplantation. Hepatology 8, 463–470.
- Yeh KH, Hsieh HC, Tang JL et al. (1994) Severe isolated acute hepatic graft-versus-host disease with vanishing bile duct syndrome. Bone Marrow Transplant 14, 319–321.
- Erlinger S (1992) Chronic graft-vs.-host disease of the liver: another indication of ursodeoxycholic acid? Hepatology 16, 1305–1307.
- Fried RH, Murakami CS, Fisher LD et al. (1992) Ursodeoxycholic acid treatment of refractory chronic graft-versus-host disease of the liver. Ann Intern Med 116, 624–629.
- Barshes NR, Myers GD, Lee D et al. (2005) Liver transplantation for severe hepatic graft-versus-host disease: an analysis of aggregate survival data. Liver Transpl 11, 525–531.
- Sharma P, McDonald GB, Banaji M (1982) The risk of bleeding after percutaneous liver biopsy: relation to platelet count. J Clin Gastroenterol 4, 451–453.
- Carreras E Grañena A Navasa M et al. (1993) Transjugular liver biopsy in BMT. Bone Marrow Transplant 11, 21–26.
- Shulman HM, Gooley T, Dudley MD et al. (1995) Utility of transven-ous liver biopsies and wedged hepatic venous pressure measurements in sixty marrow transplant recipients. Transplantation 59, 1015–1022.
- Lee JL, Gooley T, Bensinger W et al. (1999) Veno-occlusive disease of the liver after busulfan, melphalan, and thiotepa conditioning therapy: incidence, risk factors, and outcome. Biol Blood Marrow Transplant 5, 306–315.
- Carreras E (2000) Veno-occlusive disease of the liver after hemopoietic cell transplantation. Eur J Haematol 64, 281–291.
- Moseley RH (2004) Sepsis and cholestasis. Clin Liver Dis 8, 83–94.
- Hebart H, Loffler J, Reitze H et al. (2000) Prospective screening by a panfungal polymerase chain reaction assay in patients at risk for fungal infections: implications for the management of febrile neutropenia. Br J Haematol 111, 635–640.
- Anttila VJ, Lamminen AE, Bondestam S et al. (1996), Magnetic resonance imaging is superior to computed tomography and ultrasonography in imaging infectious liver foci in acute leukaemia. Eur J Haematol 56 (1–2), 82–87.
- Snover DC, Weisdorf S, Bloomer J et al. (1989) Nodular regenerative hyperplasia of the liver following bone marrow transplantation. Hepatology 9, 443–448.
- Sandhu IS, Jarvis C, Everson GT (1999) Total parenteral nutrition and cholestasis. Clin Liver Dis 3, 489–508.
- Jacobson AF, Teefey SA, Lee SP et al. (1993) Frequent occurrence of new hepatobiliary abnormalities after bone marrow transplantation: results of a prospective study using scintigraphy and sonography. Am J Gastroenterol 88, 1044–1049.
- Ko CW, Murakami C, Sekijima JH et al. (1996) Chemical composition of gallbladder sludge in patients after marrow transplantation. Am J Gastroenterol 91, 1207–1210.
