Chapter 24

Neurodegeneration and Dementia

John Hardy

John Hardy

Laboratory of Neurogenetics, National Institutes of Health, Bethesda, MD, USA

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Scott A. Small

Scott A. Small

Department of Neurology, Columbia University, New York, NY, USA

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First published: 16 April 2008

Summary

A deeper understanding of the neuroanatomy of cognition and the pathogenesis of disease has refined the definitions of both “dementia” and “neurodegeneration.” By reviewing a sampling of neurodegenerative illness, those in which the greatest scientific discovery has been made, this chapter will highlight and clarify emerging principles relevant to the category as a whole. In particular, this chapter will focus on Alzheimer's disease, frontal temporal dementia, Lewy body dementia, and prion diseases.

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