Abstract
Alternative splicing of pre-messenger ribonucleic acid (pre-mRNA) allows the generation of different mRNAs from the same gene. Evolution of alternative splicing affecting translated regions of mRNAs permits the synthesis of different proteins from a single gene, significantly increasing the diversity of the protein repertoire.
References
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Further Reading
- Bhasi A, Pandey RV, Utharasamy SP and Senapathy P (2007) EuSplice: a unified resource for the analysis of splice signals and alternative splicing in eukaryotic genes. Bioinformatics 23: 1815–1823.
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- Smith CW and Valcarcel J (2000) Alternative pre-mRNA splicing: the logic of combinatorial control. Trends in Biochemical Sciences 25: 381–388.
- Zavolan M and van Nimwegen E (2006) The types and prevalence of alternative splice forms. Current Opinion in Structural Biology 16: 362–367.
Useful Internet Resources
- ESEfinder is a web resource that identifies exonic splicing enhancers. http://rulai.cshl.edu/tools/ESE/index.html.
- EuSplice is a unique resource which provides reliable splice signal and alternative splicing information for 23 eukaryotic genomes. http://66.170.16.154/EuSplice/.
- The ACESCAN2 Web Server is an online tool for identifying candidate cis-elements (exonic splicing enhancers and silencers, intronic splicing enhancers) in alternative and constitutive splicing in mammalian exons. http://genes.mit.edu/acescan2/index.html.
- The Alternative Exon Database (AEDB) is a manually generated database for human alternative exons and their properties: the data is gathered from literature where these exons have been experimentally verified. http://www.ebi.ac.uk/asd/aedb/index.html.
- The Alternative Splicing Database (ASD) Project aims to understand the mechanism of alternative splicing on a genome-wide scale by creating a database of alternative splice events and the resultant isoform splice patterns of genes from human, and other model species. http://www.ebi.ac.uk/asd/.
- The AltExtron Database is a computer generated high quality dataset of human transcript-confirmed constitutive and alternative exons and introns. http://www.ebi.ac.uk/asd/altextron/index.html.
- The FAS-ESS Web Server is an online tool for the systematic identification and analysis of exonic splicing silencers. http://genes.mit.edu/fas-ess/.
- The RESCUE-ESE Web Server is an online tool for identifying candidate ESEs in vertebrate exons. http://genes.mit.edu/burgelab/rescue-ese/.
Citing Literature
