Hemozoin: a Biocrystal Synthesized during the Degradation of Hemoglobin

Part 9. Miscellaneous Biopolymers and Biodegradation of Polymers
Prof. Dr. David J. Sullivan Jr.

Prof. Dr. David J. Sullivan Jr.

Johns Hopkins University, The Malaria Research Institute, W. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, 615 North Wolfe St., Baltimore, MD, USA, 21205

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First published: 15 January 2005
Citations: 7

Abstract

  • Introduction
    • Malaria
    • Malaria Pathogenesis
    • Hemoglobin Degradation
  • Historical Outline
    • Pigment Associates with Malaria
    • Pigment Links Mosquito to Plasmodium Life Cycle
  • Chemical Structure
  • Occurrence
  • Function of Hemozoin
  • Structure of Hemozoin
    • Analysis of Early Purifications
    • Comparison with Schistosomal Pigment
    • Hemozoin Lacks Protein
    • The Iron–Oxygen Coordinate Bond
    • Paramagnetic Hemozoin
  • Biochemical Formation of Hemozoin
    • Formalin Pigment
    • Other Parasite Pigments
    • Plasmodium Protein Initiation of Pigment
  • Inhibition of Hemozoin Formation
  • Immune Modulation of Hemozoin
    • Perturbation of Leukocyte Function
    • Leukocyte Pigment as a Prognostic Indicator
  • Patents
  • Outlook and Perspectives

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