Hyaluronan

Part 5. Polysaccharides
Prof. Dr. Peter Prehm

Prof. Dr. Peter Prehm

Institut für Physiologische Chemie und Pathobiochemie, Waldeyerstr. 15, Münster, Germany, D-48129

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First published: 15 January 2005

Abstract

  • Introduction
  • Historical Outline
  • Chemical Structure
  • Occurrence of Hyaluronan
  • Mechanism of Hyaluronan Synthesis
    • Chain Elongation
    • Chain Size
    • Chain Export
    • Swelling
    • Macromolecular Assembly
  • Hyaluronan Synthases
  • Hyaluronan-binding Proteins and Receptors
    • CD44
    • RHAMM
    • Other Hyaluronan-binding Proteins
  • Mechanisms of Hyaluronan Release from the Cell Surface
  • Regulation of Hyaluronan Synthesis
    • Expression of the Synthase
    • Stimulation and Inhibition of the Synthase
      • Signal Transduction at Membranes
      • Intracellular Signal Transduction
    • Influence of Chain Length on Further Elongation
  • Turnover and Catabolism
  • Functions of Hyaluronan
    • Cellular Functions
    • Physiological Functions
      • Differentiation and Morphogenesis
      • Wound Healing
      • Synovia
    • Pathological Functions
      • Metastasis
      • Edema
      • Streptococci
  • Hyaluronan Degradation
    • Degradation by Free Radicals
    • Degradation by Hyaluronidases
  • Production
    • Patents
    • Market
  • Medical Applications
    • Ophthalmics
    • Arthritis
    • Wound Healing and Scarring
    • Adhesion Prevention
    • Drug Delivery
  • Effects of Hyaluronan Oligosaccharides
  • Outlook and Perspectives

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