Biosynthetic Routes to the Building Blocks of Isoprenoids

Part 2. Polyisoprenoids
Prof.Dr. Michel Rohmer

Prof.Dr. Michel Rohmer

Université Louis Pasteur/CNRS, Institut Le Bel, 4 rue Blaise Pascal, Strasbourg Cedex, France, 67070

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Dr. Myriam Seemann

Dr. Myriam Seemann

Université Louis Pasteur/CNRS, Institut Le Bel, 4 rue Blaise Pascal, Strasbourg Cedex, France, 67070

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Dr. Catherine Grosdemange-Billiard

Dr. Catherine Grosdemange-Billiard

Université Louis Pasteur/CNRS, Institut Le Bel, 4 rue Blaise Pascal, Strasbourg Cedex, France, 67070

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First published: 15 January 2005
Citations: 4

Abstract

  • Introduction: Recognition of the Isoprene Unit and Isoprenoids
  • Historical Outline
  • The Classical Mevalonate Pathway
  • The Recently Discovered Methylerythritol Phosphate Pathway
  • Labeling Experiments: Discovery and Elucidation of the MEP Pathway
    • Origin of the Carbon Skeleton of Isoprene Units
    • Identification of Deoxyxylulose and Methylerythritol Derivatives as the First C5 Isoprenoid Precursors
  • Enzymology and Genetics
    • 1-Deoxy-D-xylulose 5-phosphate Synthase
    • 1-Deoxy-D-xylulose 5-phosphate Isomero-reductase
    • From Methylerythritol Phosphate to Methylerythritol Cyclodiphosphate
  • On the Origin of the Hydrogen Atoms in Isoprene Units: Indications on Further Steps
  • Distribution of the MEP Pathway and Evolutionary Impacts
  • Outlook and Perspectives

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