Perfusion-weighted imaging of interictal hypoperfusion in temporal lobe epilepsy using FAIR-HASTE: Comparison with H215O PET measurements
Ho-Ling Liu
Research Imaging Center, University of Texas Health Science Center, San Antonio, Texas
Department of Medical Technology, Chang Gung University, Taoyuan, Taiwan
Department of Diagnostic Radiology, Chang Gung Medical Center, Taoyuan, Taiwan
Search for more papers by this authorPeter Kochunov
Research Imaging Center, University of Texas Health Science Center, San Antonio, Texas
Search for more papers by this authorJinwen Hou
Research Imaging Center, University of Texas Health Science Center, San Antonio, Texas
Department of Radiology, Shandong Medical University, Jiana, Shangdong, China
Search for more papers by this authorYonglin Pu
Research Imaging Center, University of Texas Health Science Center, San Antonio, Texas
Search for more papers by this authorSrikanth Mahankali
Research Imaging Center, University of Texas Health Science Center, San Antonio, Texas
Search for more papers by this authorChing-Mei Feng
Research Imaging Center, University of Texas Health Science Center, San Antonio, Texas
Search for more papers by this authorSeong-Hwan Yee
Research Imaging Center, University of Texas Health Science Center, San Antonio, Texas
Search for more papers by this authorYung-Liang Wan
Department of Medical Technology, Chang Gung University, Taoyuan, Taiwan
Department of Diagnostic Radiology, Chang Gung Medical Center, Taoyuan, Taiwan
Search for more papers by this authorPeter T. Fox
Research Imaging Center, University of Texas Health Science Center, San Antonio, Texas
Search for more papers by this authorCorresponding Author
Jia-Hong Gao
Research Imaging Center, University of Texas Health Science Center, San Antonio, Texas
Research Imaging Center, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78284-6240===Search for more papers by this authorHo-Ling Liu
Research Imaging Center, University of Texas Health Science Center, San Antonio, Texas
Department of Medical Technology, Chang Gung University, Taoyuan, Taiwan
Department of Diagnostic Radiology, Chang Gung Medical Center, Taoyuan, Taiwan
Search for more papers by this authorPeter Kochunov
Research Imaging Center, University of Texas Health Science Center, San Antonio, Texas
Search for more papers by this authorJinwen Hou
Research Imaging Center, University of Texas Health Science Center, San Antonio, Texas
Department of Radiology, Shandong Medical University, Jiana, Shangdong, China
Search for more papers by this authorYonglin Pu
Research Imaging Center, University of Texas Health Science Center, San Antonio, Texas
Search for more papers by this authorSrikanth Mahankali
Research Imaging Center, University of Texas Health Science Center, San Antonio, Texas
Search for more papers by this authorChing-Mei Feng
Research Imaging Center, University of Texas Health Science Center, San Antonio, Texas
Search for more papers by this authorSeong-Hwan Yee
Research Imaging Center, University of Texas Health Science Center, San Antonio, Texas
Search for more papers by this authorYung-Liang Wan
Department of Medical Technology, Chang Gung University, Taoyuan, Taiwan
Department of Diagnostic Radiology, Chang Gung Medical Center, Taoyuan, Taiwan
Search for more papers by this authorPeter T. Fox
Research Imaging Center, University of Texas Health Science Center, San Antonio, Texas
Search for more papers by this authorCorresponding Author
Jia-Hong Gao
Research Imaging Center, University of Texas Health Science Center, San Antonio, Texas
Research Imaging Center, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78284-6240===Search for more papers by this authorAbstract
To detect perfusion abnormalities in areas of high magnetic susceptibility in the brain, an arterial spin-labeling MRI technique utilizing flow-sensitive alternating inversion recovery (FAIR) and half-Fourier single shot turbo spin-echo (HASTE) for spin preparation and image acquisition, respectively, was developed. It was initially tested in a functional study involving visual stimulation, and was able to detect significant activation with an increase (approximately 70%) in relative cerebral blood flow. Subsequently, it was applied in a clinical situation in eight patients with temporal lobe epilepsy (TLE). The perfusion-weighted images obtained showed no susceptibility artifacts even in the region of the inferior temporal lobe and were able to detect interictal hypoperfusion in TLE. The results were compared with those derived from H215O PET perfusion imaging in each patient. A statistically significant correlation (r = 0.75, P < 0.05) was found between results acquired from these two modalities. Magn Reson Med 45:431–435, 2001. © 2001 Wiley-Liss, Inc.
REFERENCES
- 1 Rosen BR, Belliveau JW, Vevea JM, Brandy TJ. Perfusion imaging with NMR contrast agents. Magn Reson Med 1990; 14: 249–265.
- 2 Belliveau JW, Rosen BR, Kantor HL. Functional cerebral imaging by susceptibility-contrast NMR. Magn Reson Med 1990; 14: 538–546.
- 3 Detre JA, Leigh JS, Williams DS, Koretsky AP. Perfusion imaging. Magn Reson Med 1992; 23: 37–45.
- 4 Warach S, Dashe JF, Edelman RR. Clinical outcome in ischemic stroke predicted by early diffusion-weighted and perfusion magnetic resonance imaging: a preliminary analysis. Cereb Blood Flow Metab 1996; 16: 53–59.
- 5 Siewert B, Schlaug G, Edelman RR, Warach S. Comparison of EPISTAR and T2*-weighted gadolinium-enhanced perfusion imaging in patients with acute cerebral ischemia. Neurology 1997; 48(3): 673–679.
- 6 Belliveau JW, Kennedy DN, McKinstry RC, Buchbinder BR, Weisskoff RM, Cohen MS, Vevea JM, Brady TJ, Rosen BR. Functional mapping of the human visual cortex by magnetic resonance imaging. Science 1991; 254: 716–719.
- 7 Edelman RR, Siewert B, Darby DG, Thangaraj V, Nobre AC, Mesulam MM, Warach S. Qualitative mapping of cerebral blood flow and functional localization with echo-planar MR imaging and signal targeting with alternating radio frequency. Radiology 1994; 192: 513–520.
- 8 Kwong KK, Chesler DA, Weisskoff RM, Donahue KM, Davis TL, Ostergaard L, Campbell TA, Rosen BR. MR perfusion studies with T1-weighted echo planar imaging. Magn Reson Med 1995; 34: 878–887.
- 9 Kim S-G. Quantification of relative cerebral blood flow change by flow-sensitive alternating inversion recovery (FAIR) technique: application to functional mapping. Magn Reson Med 1995; 34: 293–301.
- 10
Liu HL,
Gao J-H.
Perfusion based event-related functional MRI.
Magn Reson Med
1999;
42:
1011–1013.
10.1002/(SICI)1522-2594(199912)42:6<1011::AID-MRM3>3.0.CO;2-R CAS PubMed Web of Science® Google Scholar
- 11 Ostergaard L, Weisskoff RM, Chesler DA, Gyldensted C, Rosen BR. High resolution measurement of cerebral blood flow using intravascular tracer bolus passages. Part I: mathematical approach and statistical analysis. Magn Reson Med 1996a; 36: 715–725.
- 12 Ostergaard L, Sorensen AG, Kwong KK, Weisskoff RM, Gyldensted C, Rosen BR. High resolution measurement of cerebral blood flow using intravascular tracer bolus passages. Part II: experimental comparison and preliminary results. Magn Reson Med 1996b; 36: 726–736.
- 13
Liu HL,
Pu Y,
Liu Y,
Nickerson LD,
Andrews T,
Fox PT,
Gao J-H.
Cerebral blood flow measurement by dynamic contrast MRI using singular value decomposition with an adaptive threshold.
Magn Reson Med
1999;
42:
167–172.
10.1002/(SICI)1522-2594(199907)42:1<167::AID-MRM22>3.0.CO;2-Q CAS PubMed Web of Science® Google Scholar
- 14 Chen Q, Siewert B, Bly BM, Warach S, Edelman RR. STAR-HASTE: perfusion imaging without magnetic susceptibility artifact. Magn Reson Med 1997; 38: 404–408.
- 15
Crelier GR,
Hoge RD,
Munger P,
Pike GB.
Perfusion-based functional magnetic resonance imaging with single-shot RARE and GRASE acquisitions.
Magn Reson Med
1999;
41:
132–136.
10.1002/(SICI)1522-2594(199901)41:1<132::AID-MRM18>3.0.CO;2-5 CAS PubMed Web of Science® Google Scholar
- 16 Bronen RA. Is there any role for gadopentetate dimeglumine administration when searching for mesial temporal sclerosis in patients with seizure? Am J Roentgenol 1995; 164(2): 503.
- 17 Kuhl DE, Engel J Jr, Phelps ME, Selin C. Epileptic patterns of local cerebral metabolism and perfusion in humans determined by emission computed tomography of 18FDG and 13NH3. Ann Neurol 1980; 45: 348–360.
- 18 Leiderman DB, Balish M, Sato S, Kufta C, Reeves P, Gaillard WD, Theodore WH. Comparison of PET measurements of cerebral blood flow and glucose metabolism for the localization of human epileptic foci. Epilepsy Res 1992; 13(2): 153–157.
- 19 Theodore WH, Gaillard WD, Sato S, Kufta C, Leiderman D. Positron emission tomography measurement of cerebral blood flow and temporal lobectomy. Ann Neurol 1994; 36: 241–244.
- 20 Gaillard WD, Fazilat S, White S, Malow B, Sato S, Reeves P, Herscovitch P, Theodore WH. Interictal metabolism and blood flow are uncoupled in temporal lobe cortex of patients with partial complex epilepsy. Neurology 1995; 45: 1841–1847.
- 21 Fink GR, Pawlik G, Stefan H, Pietrzyk U, Wienhard K, Heiss WD. Temporal lobe epilepsy: evidence evidence for interictal uncoupling of blood flow and glucose metabolism in temporomesial structures. J Neurol Sci 1996; 137: 28–34.
- 22 Markand ON, Salanova V, Worth R, Park HM, Wellman HN. Comparative study of interictal PET and ictal SPECT in partial complex seizures. Acta Neurologica Scandinavica 1997; 95: 129–136.
- 23 Wu RH, Bruening R, Noachtar S, Arnold S, Berchtenbreiter C, Bartenstein P, Drzezga A, Tatsch K, Reiser M. MR measurement of regional relative cerebral blood volume in epilepsy. J Magn Reson Imaging 1999; 9: 435–440.
- 24 Kiefer B, Grassner J, Hausmann R. Image acquisition in a second with a half-Fourier–acquisition single-shot turbo spin echo. J Magn Reson Imaging 1994; 4: 86.
- 25 Hennig J, Friedburg H. Clinical applications and methodological developments of the RARE technique. Magn Reson Imaging 1988; 6: 391–395.
- 26 Listerud JL, Einstein S, Outwater E, Kressel HY. First principles of fast spin-echo. Magn Reson Q 1992; 8: 199–244.
- 27 Gao J-H, Xiong J, Li J, Schiff J, Roby J, Lancaster JL, Fox PT. Fast spin-echo characteristics of visual stimulation-induced signal changes in the human brain. J Magn Reson Imaging 1995; 5: 709–714.
- 28 Fox PT, Perlmutter JS, Raichle ME. A stereotactic method of anatomical localization for positron emission tomograpghy. J Comput Assist Tomogr 1985; 9: 141–153.
- 29 Xiong J, Gao J-H, Lancaster JL, Fox PT. Clustered pixels analysis for functional MRI activation studies in human brain. Human Brain Mapping 1995; 3: 287–301.
- 30 Lancaster JL, Fox PT, Downs H, Nickerson DS, Hander TA, Mallah ME, Kochunov PV, Zamarripa F. Global spatial normalization of human brain using convex hulls. J Nucl Med 1999; 40: 942–955.
- 31 Pardo FS, Aronen HJ, Kennedy D, Moulton G, Paiva K, Okunieff P, Schmidt EV, Hochberg FH, Harsh GR, Fischman AJ. Functional cerebral imaging in the evaluation and radiotherapeutic treatment planning of patients with malignant glioma. Int J Radiat Oncol Biol Phys 1994; 30(3): 663–669.
- 32 Fish DR, Brooks DJ, Young IR, Bydder GM. Use of magnetic resonance imaging to identify changes in cerebral blood flow in epilepsia partialis continua. Magn Reson Med 1988; 8: 238–240.
- 33 Warach S, Levin JM, Schomer DL, Holman BL, Edelman RR. Hyperperfusion of ictal seizure focus demonstrated by MR perfusion imaging. Am J Neuroradiol 1994; 15(5): 965–968.
- 34 Desmond JE, Sum JM, Wagner AD, Demb JB, Shear PK, Glover GH, Gabrieli JD, Morrell MJ. Functional MRI measurement of language lateralization in Wada-tested patients. Brain 1995; 118: 1411–1419.
- 35 Casey BJ, Cohen JD, Jezzard P, Turner R, Noll DC, Trainor RJ, Giedd J, Kaysen D, Hertz-Pannier L, Rapoport JL. Activation of prefrontal cortex in children during a nonspatial working memory task with functional MRI. NeuroImage 1995; 2: 221–229.
- 36
Kim SG,
Tsekos NV,
Ashe J.
Multi-slice perfusion-based functional MRI using the FAIR technique: comparison of CBF and BOLD effects.
NMR Biomed
1997;
10(4–5):
191–196.
10.1002/(SICI)1099-1492(199706/08)10:4/5<191::AID-NBM460>3.0.CO;2-R CAS PubMed Web of Science® Google Scholar
- 37 Edelman RR, Chen Q. EPISTAR MRI: multislice mapping of cerebral blood flow. Magn Reson Med 1998; 40(6): 800–805.
- 38 Alsop DC, Detre JA. Multisection cerebral blood flow MR imaging with continuous arterial spin labeling. Radiology 1998; 208(2): 410–416.
- 39 Wong EC, Buxton RB, Frank LR. Quantitative imaging of perfusion using a single subtraction (QUIPSS and QUIPSS II). Magn Reson Med 1998; 39(5): 702–708.
