Detection and localization of pulmonary air leaks using laser-polarized 3He MRI
Corresponding Author
David A. Roberts
Department of Radiology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania
Assistant Professor of Radiology, University of Pennsylvania Medical Center, Philadelphia, PA 19104-4283===Search for more papers by this authorRahim R. Rizi
Department of Radiology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania
Search for more papers by this authorDavid A. Lipson
Department of Pulmonary Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania
Search for more papers by this authorMargaret Aranda
Department of Anesthesiology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania
Search for more papers by this authorJames Baumgardner
Department of Anesthesiology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania
Search for more papers by this authorLisa Bearn
Department of Anesthesiology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania
Search for more papers by this authorJohn Hansen-Flaschen
Department of Pulmonary Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania
Search for more papers by this authorWarren B. Gefter
Department of Radiology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania
Search for more papers by this authorHiroto H. Hatabu
Department of Radiology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania
Search for more papers by this authorJohn S. Leigh Jr.
Department of Radiology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania
Search for more papers by this authorMitchell D. Schnall
Department of Radiology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania
Search for more papers by this authorCorresponding Author
David A. Roberts
Department of Radiology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania
Assistant Professor of Radiology, University of Pennsylvania Medical Center, Philadelphia, PA 19104-4283===Search for more papers by this authorRahim R. Rizi
Department of Radiology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania
Search for more papers by this authorDavid A. Lipson
Department of Pulmonary Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania
Search for more papers by this authorMargaret Aranda
Department of Anesthesiology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania
Search for more papers by this authorJames Baumgardner
Department of Anesthesiology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania
Search for more papers by this authorLisa Bearn
Department of Anesthesiology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania
Search for more papers by this authorJohn Hansen-Flaschen
Department of Pulmonary Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania
Search for more papers by this authorWarren B. Gefter
Department of Radiology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania
Search for more papers by this authorHiroto H. Hatabu
Department of Radiology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania
Search for more papers by this authorJohn S. Leigh Jr.
Department of Radiology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania
Search for more papers by this authorMitchell D. Schnall
Department of Radiology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania
Search for more papers by this authorAbstract
Pulmonary air leaks were created in the lungs of Yorkshire pigs. Dynamic, 3D MRI of laser-polarized 3He gas was then performed using a gradient-echo pulse sequence. Coronal magnitude images of the helium distribution were acquired during gas inhalation with a voxel resolution of approximately 1.2 × 2.5 × 8 mm, and a time resolution of 5 sec. In each animal, the ventilation images reveal focal high-signal intensity within the pleural cavity at the site of the air leaks. In addition, a wedge-shaped region of increased parenchymal signal intensity was observed adjacent to the site of the air leak in one animal. 3He MRI may prove helpful in the management of patients with pulmonary air leaks. Magn Reson Med 44:379–382, 2000. © 2000 Wiley-Liss, Inc.
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