Synthesis and Biological Activity of the Structural Analogues of (—)-Cabenegrin A-I
Katalin Gulácsi
Department of Organic Chemistry, University of Debrecen, P.O.Box 20, H-4010 Debrecen, Hungary
Search for more papers by this authorGyörgy Litkei
Department of Organic Chemistry, University of Debrecen, P.O.Box 20, H-4010 Debrecen, Hungary
Search for more papers by this authorCorresponding Author
Sándor Antus
Department of Organic Chemistry, University of Debrecen, P.O.Box 20, H-4010 Debrecen, Hungary
Department of Organic Chemistry, University of Debrecen, P.O.Box 20, H-4010 Debrecen, HungarySearch for more papers by this authorCsaba Szántay
Institute of Organic Chemistry, Technical University, P.O.Box 91, H-1111 Budapest, Hungary
Search for more papers by this authorLászló L. Darkó
Farmacon Inc., 90 Grove Street, Suite 109 Ridgefield, Connecticut 06877-4118, USA
Search for more papers by this authorJudith Szelényi
Department of Pharmacology, Institute of Experimental Medicine, Hungarian Academy of Sciences, P.O.Box 67, H-1450 Budapest, Hungary
Search for more papers by this authorGyörgy Haskó
Department of Pharmacology, Institute of Experimental Medicine, Hungarian Academy of Sciences, P.O.Box 67, H-1450 Budapest, Hungary
Search for more papers by this authorSzilveszter E. Vizi
Department of Pharmacology, Institute of Experimental Medicine, Hungarian Academy of Sciences, P.O.Box 67, H-1450 Budapest, Hungary
Search for more papers by this authorKatalin Gulácsi
Department of Organic Chemistry, University of Debrecen, P.O.Box 20, H-4010 Debrecen, Hungary
Search for more papers by this authorGyörgy Litkei
Department of Organic Chemistry, University of Debrecen, P.O.Box 20, H-4010 Debrecen, Hungary
Search for more papers by this authorCorresponding Author
Sándor Antus
Department of Organic Chemistry, University of Debrecen, P.O.Box 20, H-4010 Debrecen, Hungary
Department of Organic Chemistry, University of Debrecen, P.O.Box 20, H-4010 Debrecen, HungarySearch for more papers by this authorCsaba Szántay
Institute of Organic Chemistry, Technical University, P.O.Box 91, H-1111 Budapest, Hungary
Search for more papers by this authorLászló L. Darkó
Farmacon Inc., 90 Grove Street, Suite 109 Ridgefield, Connecticut 06877-4118, USA
Search for more papers by this authorJudith Szelényi
Department of Pharmacology, Institute of Experimental Medicine, Hungarian Academy of Sciences, P.O.Box 67, H-1450 Budapest, Hungary
Search for more papers by this authorGyörgy Haskó
Department of Pharmacology, Institute of Experimental Medicine, Hungarian Academy of Sciences, P.O.Box 67, H-1450 Budapest, Hungary
Search for more papers by this authorSzilveszter E. Vizi
Department of Pharmacology, Institute of Experimental Medicine, Hungarian Academy of Sciences, P.O.Box 67, H-1450 Budapest, Hungary
Search for more papers by this authorAbstract
A series of phenylbutene and butanol derivatives (6a—j, 12, 13, 15, 17, 24b,c, 26, 27a,b) were prepared from the readily available resorcinol derivatives 2a—f and 7-hydroxy-chroman (18). The products were tested for inhibitory activity on the LPS-induced TNF-α production in the plasma in comparison with that of cabenegrin A-I (1a).
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