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Fast, Convenient, and Efficient Molybdenum-Catalyzed Asymmetric Allylic Alkylation under Noninert Conditions: An Example of Microwave-Promoted Fast Chemistry

Nils-Fredrik K. Kaiser

Department of Organic Pharmaceutical Chemistry Uppsala Biomedical Centre, Uppsala University P.O. Box 574, 751 23 Uppsala (Sweden) Fax: (+46) 18-471-4474

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Ulf Bremberg Dr.,

Ulf Bremberg Dr.

Department of Chemistry, Organic Chemistry Royal Institute of Technology 100 44 Stockholm (Sweden)

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Mats Larhed Dr.,

Mats Larhed Dr.

[email protected]

Department of Organic Pharmaceutical Chemistry Uppsala Biomedical Centre, Uppsala University P.O. Box 574, 751 23 Uppsala (Sweden) Fax: (+46) 18-471-4474

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Christina Moberg Prof.,

Christina Moberg Prof.

Department of Chemistry, Organic Chemistry Royal Institute of Technology 100 44 Stockholm (Sweden)

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Anders Hallberg Prof.,

Anders Hallberg Prof.

Department of Organic Pharmaceutical Chemistry Uppsala Biomedical Centre, Uppsala University P.O. Box 574, 751 23 Uppsala (Sweden) Fax: (+46) 18-471-4474

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Nils-Fredrik K. Kaiser,

Nils-Fredrik K. Kaiser

Department of Organic Pharmaceutical Chemistry Uppsala Biomedical Centre, Uppsala University P.O. Box 574, 751 23 Uppsala (Sweden) Fax: (+46) 18-471-4474

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Ulf Bremberg Dr.,

Ulf Bremberg Dr.

Department of Chemistry, Organic Chemistry Royal Institute of Technology 100 44 Stockholm (Sweden)

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Mats Larhed Dr.,

Mats Larhed Dr.

[email protected]

Department of Organic Pharmaceutical Chemistry Uppsala Biomedical Centre, Uppsala University P.O. Box 574, 751 23 Uppsala (Sweden) Fax: (+46) 18-471-4474

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Christina Moberg Prof.,

Christina Moberg Prof.

Department of Chemistry, Organic Chemistry Royal Institute of Technology 100 44 Stockholm (Sweden)

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Anders Hallberg Prof.,

Anders Hallberg Prof.

Department of Organic Pharmaceutical Chemistry Uppsala Biomedical Centre, Uppsala University P.O. Box 574, 751 23 Uppsala (Sweden) Fax: (+46) 18-471-4474

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First published: 13 October 2000

https://doi.org/10.1002/1521-3773(20001016)39:20<3595::AID-ANIE3595>3.0.CO;2-S

Citations: 100

We gratefully acknowledge financial support from Personal Chemistry, the Swedish Natural Science Research Council (C.M.), and the Swedish Research Council for Engineering Sciences (M.L., A.H.).

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Abstract

Microwave heating allows regio- and enantioselective allylic alkylation to be carried out in air in a few minutes in a convenient one-pot procedure [Eq. (1)]. The catalytically active molybdenum(0) species was formed in situ from inexpensive [Mo(CO)₆] and a chiral ligand.

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References

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Volume39, Issue20

October 16, 2000

Pages 3595-3598

Fast, Convenient, and Efficient Molybdenum-Catalyzed Asymmetric Allylic Alkylation under Noninert Conditions: An Example of Microwave-Promoted Fast Chemistry

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Fast, Convenient, and Efficient Molybdenum-Catalyzed Asymmetric Allylic Alkylation under Noninert Conditions: An Example of Microwave-Promoted Fast Chemistry

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