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A New Role for Polyketides
Jürgen Rohr Prof. Dr.,
Jürgen Rohr Prof. Dr.
Medical University of South Carolina Department of Pharmaceutical Sciences 171 Ashley Avenue, Charleston, SC 29425-2303 (USA) Fax: (+1) 843-792-0759
Search for more papers by this authorJürgen Rohr Prof. Dr.,
Jürgen Rohr Prof. Dr.
Medical University of South Carolina Department of Pharmaceutical Sciences 171 Ashley Avenue, Charleston, SC 29425-2303 (USA) Fax: (+1) 843-792-0759
Search for more papers by this authorFirst published: 11 August 2000
Citations: 112
Abstract
A toxic determinant of the human skin disease the Buruli ulcer, which is caused by Mycobacterium ulcerans, has been identified for the first time as containing two polyketides. The novel structures of these twelve-membered macrolides (one of which is shown) reveal an unusual biosynthesis, in which two type 1 polyketide synthases (PKS) have to be involved. There is also evidence that the polyketide toxin might represent the first of a family of virulence factors associated with other mycobacterial diseases, such as leprosy and tuberculosis.
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