Chronomedicine
2
Germaine CornÉlissen,
Franz Halberg,
Germaine CornÉlissen
University of New Mexico, Albuquerque, NM, USA
Search for more papers by this authorGermaine CornÉlissen,
Franz Halberg,
Germaine CornÉlissen
University of New Mexico, Albuquerque, NM, USA
Search for more papers by this authorAbstract
Chronobiology (from chronos, time; bios, life; and logos, science) investigates the mechanisms underlying variability in the otherwise unassessed physiological range, including rhythms found in us, resonating with cycles around us. Broad time structures (chronomes) consisting of deterministic chaos and trends organized by rhythms are found in organisms and in their environments. They are mapped by chronomics as the reference values for both an applied chronomedicine and a basic chronobiology. Chronomics quantify health, identifying new disease risks, diagnosing predisease and overt illness, enabling timely and timed treatment (Rx), and validating the short- and long-term efficacy of a given Rx on an inferential statistical individualized (as well as population) basis.
Further Reading
- Bingham, C., Arbogast, B., Cornélissen, G., Lee, J. K. & Halberg, F. (1982). Inferential statistical methods for estimating and comparing cosinor parameters, Chronobiologia 9, 397–439.
- Bingham, C., Cornélissen, G. & Halberg, F. (1993). Power of “Phase 0” chronobiologic trials at different signal-to-noise ratios and sample sizes, Chronobiologia 20, 179–190.
- Burioka, N., Cornélissen, G., Halberg, F., Kaplan, D. T., Suyama, H., Sako, T. & Shimizu, E. (2003). Approximate entropy of human respiratory movement during eye-closed waking and different sleep stages, Chest 123, 80–86.
- Cornélissen, G. & Halberg, F. (1994). Introduction to Chronobiology. Medtronic Chronobiology Seminar No. 7, April 1994, http://www.msi.umn.edu/∼halberg.
- Cornélissen, G. & Halberg, F. (1996). Impeachment of casual blood pressure measurements and the fixed limits for their interpretation and chronobiologic recommendations, in Time-dependent Structure and Control of Arterial Blood Pressure, F. Portaluppi & M. H. Smolensky, eds; Annals of the New York Academy of Sciences 783, 24–46.
- Cornélissen, G., Halberg, F., Breus, T., Syutkina, E. V., Baevsky, R., Weydahl, A., Watanabe, Y., Otsuka, K., Siegelova, J., Fiser, B. & Bakken, E. E. (2002). Non-photic solar associations of heart rate variability and myocardial infarction, Journal of Atmospheric and Solar-Terrestrial Physics 64, 707–720.
- Halberg, F. (1959). Physiologic 24-hour periodicity; general and procedural considerations with reference to the adrenal cycle, Zeitschrift für Vitamin-, Hormon und Fermentforschung 10, 225–296.
- Halberg, F. (1969). Chronobiology, Annual Review of Physiology 31, 675–725.
- Halberg, F. (1980). Chronobiology: Methodological problems, Acta Medica Romana 18, 399–440.
- Halberg, F. (1983). Quo vadis basic and clinical chronobiology: promise for health maintenance, American Journal of Anatomy 168, 543–594.
- Halberg, F., Bakken, E., Cornélissen, G., Halberg, J., Halberg, E., Wu, J., Sánchez de la Peña, S., Delmore, P. & Tarquini, B. (1990). Chronobiologic blood pressure assessment with a cardiovascular summary, the sphygmochron, in Blood Pressure Measurements, W. Meyer-Sabellek, M. Anlauf, R. Gotzen & L. Steinfeld, eds. Steinkopff-Verlag, Darmstadt, pp. 297–326.
- Halberg, F. & Bingham, C. (1987). The scope and promise of chronobiology and biostatistics: interpenetrating, inseparable disciplines, in Proceedings of the Biopharmaceutical Section, American Statistical Association. Chicago, August 15–18, pp. 11–32.
- Halberg, F., Bingham, C. & Cornélissen, G. (1993). Clinical trials: the larger the better? Chronobiologia 20, 193–212.
- Halberg, F. & Cornélissen, G. (1995). International Womb-to-Tomb Chronome Initiative Group: Resolution from a meeting of the international society for research on civilization diseases and the environment (New SIRMCE confederation), in Fairy Tale or Reality? Medtronic Chronobiology Seminar No. 8. Brussels, March 17–18, 1995; http://www.msi.umn.edu/∼halberg/, April 1995.
-
Halberg, F.,
Cornélissen, G.,
Katinas, G.,
Syutkina, E. V.,
Sothern, R. B.,
Zaslavskaya, R.,
Halberg, F.,
Watanabe, Y.,
Schwartzkopff, O.,
Otsuka, K.,
Tarquini, R.,
Perfetto, F. &
Siegelova, J.
(2003).
Transdisciplinary unifying implications of circadian findings in the 1950s.
J Circadian Rhythms
1, 2. pp.
61 www.JCircadianRhythms.com/content/pdf/1740-3391/1/2.pdf.
10.1186/1740-3391-1-2 Google Scholar
- Halberg, F., Cornélissen, G., Otsuka, K., Katinas, G. & Schwartzkopff, O. (2001). Essays on chronomics spawned by transdisciplinary chronobiology. Witness in time: Earl Elmer Bakken, Neuroendocrinology Letters 22, 359–384.
- Halberg, F., Cornélissen, G., Otsuka, K., Schwartzkopff, O., Halberg, J. & Bakken, E. E. (2001). Chronomics, Biomedicine and Pharmacotherapy 55, (Suppl. 1), 153–190.
- Halberg, F., Halberg, E., Barnum, C. P. & Bittner, J. J. (1959). Physiologic 24-hour periodicity in human beings and mice, the lighting regimen and daily routine, in Photoperiodism and Related Phenomena in Plants and Animals, Publ. No. 55, R. B. Withrow, ed. American Association for the Advancement of Science, Washington, DC, pp. 803–878.
- Halberg, F., Lee, J. K. & Nelson, W. L. (1978). Time-qualified reference intervals—chronodesms, Experientia (Basel) 34, 713–716.
- Hawkins, D. M. (1987). Self-starting CUSUM charts for location and scale, Statistician 36, 299–315.
- Johnson, E. A., Haus, E., Halberg, F. & Wadsworth, G. L. (1959). Graphic monitoring of seizure incidence changes in epileptic patients, Minnesota Medicine 42, 1250–1257.
-
S. L. Macey ed.
(1994).
Encyclopedia of Time.
Garland,
New York.
10.4324/9780203054147 Google Scholar
- Marquardt, D. W. (1963). An algorithm for least-squares estimation of nonlinear parameters, Journal of the Society of Industrial and Applied Mathematics 11, 431–441.
- Nelson, W., Cornélissen, G., Hinkley, D., Bingham, C. & Halberg, F. (1983). Construction of rhythm-specified reference intervals and regions, with emphasis on “hybrid” data, illustrated for plasma cortisol, Chronobiologia 10, 179–193.
- Otsuka, K., Cornélissen, G. & Halberg, F. (1996). Predictive value of blood pressure dipping and swinging with regard to vascular disease risk. Clinical Drug Investigation 11, 20–31.
- Otsuka, K., Cornélissen, G. & Halberg, F. (1997). Circadian rhythmic fractal scaling of heart rate variability in health and coronary artery disease. Clinical Cardiology 20, 631–638.
-
Otsuka, K.,
Cornélissen, G.,
Weydahl, A.,
Holmeslet, B.,
Hansen, T. L.,
Shinagawa, M.,
Kubo, Y.,
Nishimura, Y.,
Omori, K.,
Yano, S. &
Halberg, F.
(2001).
Geomagnetic disturbance associated with decrease in heart rate variability in a subarctic area,
Biomedicine and Pharmacotherapy
55, (Suppl. 1),
51–56.
10.1016/S0753-3322(01)90005-8 Google Scholar
- Reinberg, A. & Smolensky, M. H. (1983). Biological rhythms and medicine. Cellular, metabolic, physiopathologic, and pharmacologic aspects. Springer, New York.
-
Shinagawa, M.,
Kubo, Y.,
Otsuka, K.,
Ohkawa, S.,
Cornélissen, G. &
Halberg, F.
(2001).
Impact of circadian amplitude and chronotherapy: relevance to prevention and treatment of stroke,
Biomedicine and Pharmacotherapy
55, (Suppl. 1),
125–132.
10.1016/S0753-3322(01)90017-4 Google Scholar
-
Smolensky, M.,
Halberg, F. &
Sargent, F. II
(1972). Chronobiology of the life sequence, in
Advances in Climatic Physiology,
S. Itoh,
K. Ogata,
H. Yoshimura, eds;
Igaku Shoin Ltd.,
Tokyo, pp.
281–318.
10.1007/978-3-642-93010-2_18 Google Scholar
- Spector, N. H., Dolina, S., Cornélissen, G., Halberg, F., Markovic, B. M. & Jankovic, B. D. (1995). Neuroimmunomodulation: neuroimmune interactions with the environment, in Handbook of Physiology, Section 4: Environmental Physiology, M. J. Fregly & C. M. Blatteis, eds; American Physiological Society/Oxford University Press, New York, pp. 1537–1550.
-
Touitou, Y. &
Haus, E.
(1992).
Biological Rhythms in Clinical and Laboratory Medicine.
Springer-Verlag,
Berlin, p.
730.
10.1007/978-3-642-78734-8 Google Scholar
- Zeman, M., Cornélissen, G., Balazova, K., Jozsa, R., Olah, A., Nagy, G., Csernus, V., Kaszaki, J., Pan, W. H., Bubenik, G. & Halberg, F. (2004). Circadian rhythm of melatonin in rat duodenum, in Proceedings, Symposium: Chronobiology in Medicine. Dedicated to the 85th Anniversary of Professor Franz Halberg, G. Cornélissen, T. Kenner, B. Fiser, J. Siegelova, eds; Masaryk University, Brno, pp. 95–97.
Citing Literature
