Characterizing white matter with magnetization transfer and T2
Corresponding Author
G.J. Stanisz
Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.
Imaging Research, Sunnybrook & Women's College Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada.
Sunnybrook & Women's College Health Sciences Centre, S646-2075 Bayview Ave., Toronto, Ontario, Canada M4N 3M5.===Search for more papers by this authorA. Kecojevic
Imaging Research, Sunnybrook & Women's College Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada.
Search for more papers by this authorM.J. Bronskill
Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.
Imaging Research, Sunnybrook & Women's College Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada.
Search for more papers by this authorR.M. Henkelman
Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.
Imaging Research, Sunnybrook & Women's College Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada.
Search for more papers by this authorCorresponding Author
G.J. Stanisz
Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.
Imaging Research, Sunnybrook & Women's College Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada.
Sunnybrook & Women's College Health Sciences Centre, S646-2075 Bayview Ave., Toronto, Ontario, Canada M4N 3M5.===Search for more papers by this authorA. Kecojevic
Imaging Research, Sunnybrook & Women's College Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada.
Search for more papers by this authorM.J. Bronskill
Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.
Imaging Research, Sunnybrook & Women's College Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada.
Search for more papers by this authorR.M. Henkelman
Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.
Imaging Research, Sunnybrook & Women's College Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada.
Search for more papers by this authorAbstract
A magnetization-transfer (MT) CPMG hybrid experiment was performed to analyze T2 relaxation and MT characteristics in bovine optic nerve. Two exchanging liquid pools with their own, independent MT characteristics were necessary to model both the T2 relaxation and the MT data. The model agrees well with the experimental data and yields physically realistic parameters. The MT effect for myelin water is approximately nine time larger than that for intra/intercellular water, indicating that the MT characteristics observed for white matter are mainly related to myelin. The model can be used to probe parameters that would be difficult to achieve experimentally. The exchange process between the two tissue compartments does not drastically affect the amplitudes and relaxation rates of the T2 components, but is fast enough to significantly influence their MT characteristics. Although, both the MT and T2 experiments described in this paper are too time consuming to be applied in routine clinical work, presented results can be useful in interpreting clinical pulse sequences that are sensitive to myelin. Magn Reson Med 42:1128–1136, 1999. © 1999 Wiley-Liss, Inc.
REFERENCES
- 1 Dousset V, Grossman RI, Ramer KN, Schnall MD, Young LH, Gonzalez-Scarano F, Lavi E, Cohen JA. Experimental allergic encephalomyelitis and multiple sclerosis: lesion characterization with magnetization transfer imaging. Radiology 1992; 182: 483–491. Medline
- 2 MacKay AL, Whittall KP, Adler J, Li DKB, Paty DW, Graeb D. In vivo visualisation of myelin water in brain by magnetic resonance. Magn Reson Med 1994; 31: 673–677. Medline
- 3 Mehta RC, Pike GB, Enzmann DR. Measure of magnetization transfer in multiple sclerosis demyelinating plaques, white matter ischemic lessions, and edema. Am J Neuroradiol 1995; 17: 1051–1055.
- 4 Lexa FJ, Grossman RI, Rosenquist AC. MR of Wallerian degeneration in the feline visual system: Characterization of magnetization transfer rate with histopathologic correlation. Am J Neuroradiol 1994; 15: 201–212. Medline
- 5 Thorpe JW, Barker GJ, Jones SJ, Moseley I, Losseff N, MacManus DG, Webb S, Mortimer C, Plummer DL, Tofts PS, McDonald WI, Miller DH. Magnetisation transfer ratios and transverse magnetisation decay curves in optic neuritis: correlation with clinical findings and electrophysiology. J Neurol Neurosurg Psychiat 1995; 59: 487–492. Medline
- 6 Kato Y, Matsumura K, Kinosada Y, Narita Y, Kuzuhara S, Nakagawa T. Detection of pyramidal tract lesions in amyotrophic lateral sclerosis with magnetization-transfer measurements. Am J Neuroradiol 1997; 18: 1541–1547. Medline
- 7 Miller DH, Albert PS, Barkhof F, Francis G, Frank JA, Hodgkinson S, Lublin FD, Paty DW, Reingold SC, Simon J. Guidelines for the use of magnetic resonance techniques in monitoring the treatment of multiple sclerosis. Ann Neurol 1996; 39: 6–16. Medline
- 8 Prineas JW, McDonald WI. In: D Lantos, editor. Demyelinating diseases. London: Greenfield's Neuropathology; 1997.
- 9 Koopmans RA, Li DKB, Zhu G, Allen PS, Penn A, Paty DW. Magnetic resonance spectroscopy of multiple sclerosis: in-vivo detection of myelin breakdown products. Lancet 1993; 341: 631–632. Medline
- 10 Goodkin DE, Rudick RA, Medendorp SVB, Daughtry MM, Van Dyke C. Low-dose oral methotrexate in chronic progressive multiple sclerosis: Analyses of serial MRIs. Neurology 1996; 47: 1153–1157. Medline
- 11 Larsson HBW, Frederiksen J, Kjaer L, Hendriksen O, Olesen J. In vivo determination of T1 and T2 in the brain of patients with severe but stable multiple sclerosis. Magn Reson Med 1988; 7: 43–55. Medline
- 12 Morrison C, Henkelman RM. A model for magnetization transfer in tissues. Magn Reson Med 1995; 33: 475–482. See also Erratum, Mag Reson Med 1996;35:277.
- 13 Harrison R, Bronskill MJ, Henkelman RM. Magnetization transfer and T2 relaxation components in tissue. Magn Reson Med 1995; 33: 490–496. Medline
- 14 Does MD, Beaulieu C, Allen PS, Snyder RE. Multi-component T1 relaxation and magnetisation transfer in peripheral nerve. Magn Reson Imag 1998; 16: 1033–1041.
- 15 Sobol WT, Cameron IG, Inch WR, Pintar MM. Modeling of proton spin relaxation in muscle tissue using nuclear magnetic resonance spin grouping and exchange analysis. J Biophys Soc 1986; 50: 181–191.
- 16 Vavasour IM, Whittall KP, MacKay AL, Li DKB, Vorobeychik G, Paty DW. A comparison between magnetization transfer ratios and myelin water percentages in normals and multiple sclerosis patients. Mag Reson Med 1998; 40: 763–768.
- 17 Henkelman RM, Huang H, Xiang Q, Stanisz GJ, Swanson SD, Bronskill MJ. Quantitative interpretation of magnetization transfer. Magn Reson Med 1993; 29: 759–766. Medline
- 18 Charvolin J, Rigny P. Pulsed NMR in dynamically heterogenous systems. J Magn Reson 1971; 4: 40–46.
- 19 Grad J, Bryant RG. Nuclear magnetic cross-relaxation spectroscopy. J Magn Reson 1990; 90: 1–8.
- 20 Kroeker RM, Henkelman RM. Analysis of biological NMR relaxation data with continuous distributions of relaxation times. J Magn Reson 1986; 69: 218–233.
- 21 Li GL, Graham SJ, Henkelman RM. A flexible magnetization transfer line shape derived from tissue experimental data. Magn Reson Med 1997; 37: 866–871. Medline
- 22 Vavasour I. Magnetic resonance of human and bovine brain. PhD thesis, The University of British Columbia, 1998.
- 23 Whittall KP, MacKay AL, Graeb DA, Nugent RA, Li DKB, Paty DW. In vivo measurement of T2 distributions and water contents in normal human brain. Magn Res Med 1994; 37: 34–43.
- 24 Yeung HN, Eisen AM. Magnetization transfer contrast with periodic pulsed saturation. Radiology 1992; 183: 209–214. Medline
- 25 Hu BS, Conolly SM, Wright GA, Nishimura DG, Macovski A. Pulsed saturation transfer contrast. Magn Reson Med 1992; 26: 231–240. Medline
- 26 Graham SJ, Henkelman RM. Understanding pulsed magnetization transfer. J Mag Reson Imag 1997; 7: 903–912.
- 27 Baratti C, Barnett AS, Pierpaoli C. Comparative MR imaging study of brain maturation in kittens with T1, T2, and the trace of the diffusion tensor. Radiology 1999; 210: 133–142. Medline
- 28 Engelbrecht V, Rassek M, Preiss S, Wald C, Modder U. Age-dependent changes in magnetization transfer contrast of white matter in the pediatric brain. Am J Neuroradiol 1998; 19: 1923–1929. Medline
- 29 Wolff S, Balaban RS. Magnetization transfer contrast (MTC) and tissue water proton relaxation in vivo. Magn Reson Med 1989; 10: 135–144. Medline
- 30 Hills BP, Favret FA. A comparative multinuclear relaxation study of protein-DSMO and protein-water interactions. J Magn Reson B 1994; 103: 142–151.
- 31 Solomon I. Relaxation processes in a system of two spins. Phys Rev 1955; 99: 559–565.
- 32 Anet FAL, O'Leary DJ. NMR lineshapes caused by transverse cross relaxation of nearly like spins. J Magn Reson 1990; 86: 358–370.
- 33 Wu X, Listinsky JJ. Effects on transverse cross relaxation on magnetization transfer. J Magn Reson B 1994; 105: 73–76.
- 34 Listerud J. Off-resonance pulsed magnetization transfer in clinical MR imaging: Optimization by an analysis of transients. Magn Reson Med 1997; 37: 693–705. Medline
- 35 Provotorov BN. Magnetic resonance saturation in crystals. Sov Phys JETP 1962; 14: 1126–1131.
- 36 Martin RH. In: Elementary differential equations with boundary value problems. McGraw-Hill Book Company; 1984.
- 37 Powell MJD. Numerical analysis. New York: Springer Verlag; 1978.
- 38 NR Draper, H Smith, editors Applied regression analysis. New York: John Wiley and Sons; 1981.
