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Evidence for the persistence of monoclonal expansions of CD8+ T cells following primary simian immunodeficiency virus infection
Jamie D. K. Wilson,
Martin Cranage,
Nicola Cook,
Sharon Leech,
Andrew J. McMichael,
Margaret F. C. Callan,
Jamie D. K. Wilson
Molecular Immunology Group, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, GB
Search for more papers by this authorMartin Cranage
Centre for Applied Microbiology & Research (CAMR), Porton Down, Salisbury, GB
Search for more papers by this authorNicola Cook
Centre for Applied Microbiology & Research (CAMR), Porton Down, Salisbury, GB
Search for more papers by this authorSharon Leech
Centre for Applied Microbiology & Research (CAMR), Porton Down, Salisbury, GB
Search for more papers by this authorAndrew J. McMichael
Molecular Immunology Group, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, GB
Search for more papers by this authorMargaret F. C. Callan
Molecular Immunology Group, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, GB
Search for more papers by this authorJamie D. K. Wilson,
Martin Cranage,
Nicola Cook,
Sharon Leech,
Andrew J. McMichael,
Margaret F. C. Callan,
Jamie D. K. Wilson
Molecular Immunology Group, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, GB
Search for more papers by this authorMartin Cranage
Centre for Applied Microbiology & Research (CAMR), Porton Down, Salisbury, GB
Search for more papers by this authorNicola Cook
Centre for Applied Microbiology & Research (CAMR), Porton Down, Salisbury, GB
Search for more papers by this authorSharon Leech
Centre for Applied Microbiology & Research (CAMR), Porton Down, Salisbury, GB
Search for more papers by this authorAndrew J. McMichael
Molecular Immunology Group, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, GB
Search for more papers by this authorMargaret F. C. Callan
Molecular Immunology Group, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, GB
Search for more papers by this authorFirst published: 28 March 2006
Citations: 16
Abstract
A longitudinal study of the CD8+ TCR variable (Vβ) chain repertoire was performed in rhesus macaques experimentally infected with simian immunodeficiency virus (SIV) using both TCR Vβ chain-specific monoclonal antibodies and TCR β chain CDR3 length analysis. Expansions of subpopulations of CD8+ T cells were detected during the acute phase of SIV infection. In all monkeys studied, monoclonal expansions persisted for at least 18 months and increasingly dominated the repertoire of CD8+ T cells expressing the relevant Vβ chain. This study shows that persistent CD8+ T cell expansions develop in response to a virus infection. This is important not only for our understanding of the T cell response to viruses but also for understanding the factors that determine the normal CD8+ TCR repertoire.
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