Volume 38, Issue 23 pp. 3504-3506
Communication

The First Catalytic Asymmetric Nitro-Mannich-Type Reaction Promoted by a New Heterobimetallic Complex

Ken-ichi Yamada

Ken-ichi Yamada

Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan, Fax: (+81) 3-5684-5206

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Simon J. Harwood

Simon J. Harwood

Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan, Fax: (+81) 3-5684-5206

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Harald Gröger

Harald Gröger

Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan, Fax: (+81) 3-5684-5206

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Masakatsu Shibasaki

Masakatsu Shibasaki

Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan, Fax: (+81) 3-5684-5206

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Abstract

The best ratio is 1:1:3 for the components Yb, K, and binaphthol in the new heterobimetallic complex, which efficiently catalyzes an asymmetric nitro-Mannich-type reaction. The desired nitro-Mannich products 2 are obtained with up to 91 % ee starting from N-phosphinoyl imines 1.

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