Volume 38, Issue 22 pp. 3311-3315
Communication

Self-Assembly of Trisoligonucleotidyls: The Case for Nano-Acetylene and Nano-Cyclobutadiene

Matthias Scheffler

Matthias Scheffler

Lehrstuhl für Bioorganische Chemie der Universität, D-44780 Bochum (Germany), Fax: (+49) 234-7094-355

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Axel Dorenbeck

Axel Dorenbeck

Lehrstuhl für Bioorganische Chemie der Universität, D-44780 Bochum (Germany), Fax: (+49) 234-7094-355

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Stefan Jordan

Stefan Jordan

Bayer AG, 51366 Leverkusen (Germany)

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Michael Wüstefeld

Michael Wüstefeld

Lehrstuhl für Bioorganische Chemie der Universität, D-44780 Bochum (Germany), Fax: (+49) 234-7094-355

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Günter von Kiedrowski

Günter von Kiedrowski

Lehrstuhl für Bioorganische Chemie der Universität, D-44780 Bochum (Germany), Fax: (+49) 234-7094-355

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Abstract

Rapid cooling is the recipe for the self-assembly of nanostructures from trisoligonucleotidyls, a novel class of branched oligonucleotides whose 3′-termini are connected by a trifunctional linker. The topology of the smallest complex is formally equivalent to the topology of acetylene, if a DNA double strand is envisioned as a C−C bond. The model of nano-acetylene is shown.

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