Communication
Enantioselective Synthesis of β-Amino Sulfones by aza-Michael Addition to Alkenyl Sulfones
First published: 04 February 2004
Citations: 54
Abstract
Regardless of whether SAMP or RAMBO (or their enantiomers RAMP or SAMBO) are used, the asymmetric synthesis of N-protected β-amino sulfones 4 by conjugate addition of a chiral nitrogen nucleophile (S)-1 (SAMP) or (R,R,R)-2 (RAMBO) to (E)-alkenyl sulfones 3 proceeds with high enantiomeric excesses. The title compounds are obtained after removal of the chiral auxiliary by reductive N−N bond cleavage.
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