Research Article

Toxicological evaluation of the hydro-alcohol extract of the dry leaves of Peumus boldus and boldine in rats

Corresponding Author

Edvaldo Rodrigues de Almeida

Laboratório de Farmacologia do Departamento de Antibióticos, Universidade Federal de Pernambuco, Recife, Pernambuco, CEP 50670-901, Brazil

Laboratório de Farmacologia do Departamento de Antibióticos, Universidade Federal de Pernambuco, Recife, Pernambuco, CEP 50670-901, BrazilSearch for more papers by this author

Antonio Mário Melo,

Antonio Mário Melo

Laboratório de Farmacologia do Departamento de Antibióticos, Universidade Federal de Pernambuco, Recife, Pernambuco, CEP 50670-901, Brazil

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Haroudo Xavier,

Haroudo Xavier

Laboratório de Farmacognosia da Faculdade de Farmácia da Universidade Federal de Pernambuco, Recife, Pernambuco, CEP 50670-901, Brazil

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Edvaldo Rodrigues de Almeida,

Corresponding Author

Edvaldo Rodrigues de Almeida

Laboratório de Farmacologia do Departamento de Antibióticos, Universidade Federal de Pernambuco, Recife, Pernambuco, CEP 50670-901, Brazil

Laboratório de Farmacologia do Departamento de Antibióticos, Universidade Federal de Pernambuco, Recife, Pernambuco, CEP 50670-901, BrazilSearch for more papers by this author

Antonio Mário Melo,

Antonio Mário Melo

Laboratório de Farmacologia do Departamento de Antibióticos, Universidade Federal de Pernambuco, Recife, Pernambuco, CEP 50670-901, Brazil

Search for more papers by this author

Haroudo Xavier,

Haroudo Xavier

Laboratório de Farmacognosia da Faculdade de Farmácia da Universidade Federal de Pernambuco, Recife, Pernambuco, CEP 50670-901, Brazil

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First published: 23 February 2000

https://doi.org/10.1002/(SICI)1099-1573(200003)14:2<99::AID-PTR600>3.0.CO;2-4

Citations: 30

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Abstract

The hydro-alcohol extract of the dry leaves of Peumus boldus and boldine, showed abortive and teratogenic action and changes in the blood levels of bilirubin, cholesterol, glucose, alanine aminotransferase (ALT), aspartate aminotransferase (AST) and urea in rats. The long term administration of the extract and boldine did not cause histological modification during a period of 90 days. Copyright © 2000 John Wiley & Sons, Ltd.

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Volume14, Issue2

March 2000

Pages 99-102

Toxicological evaluation of the hydro-alcohol extract of the dry leaves of Peumus boldus and boldine in rats

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Toxicological evaluation of the hydro-alcohol extract of the dry leaves of Peumus boldus and boldine in rats

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