Research Article

Antiviral effect of flavonoids on the Dengue virus

I. Sánchez

Instituto de Investigaciones Biomédicas, UNAM, Depto. de Biología Molecular, Circuito Interior, Ciudad Universitaria, 04510 México, D.F.

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F. Gómez-Garibay,

F. Gómez-Garibay

Instituto de Química, UNAM. Circuito Exterior, Ciudad Universitaria, 04510 México, D.F.

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J. Taboada,

J. Taboada

Instituto de Investigaciones Biomédicas, UNAM, Depto. de Biología Molecular, Circuito Interior, Ciudad Universitaria, 04510 México, D.F.

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Dr B. H. Ruiz,

Corresponding Author

Dr B. H. Ruiz

Instituto de Investigaciones Biomédicas, UNAM, Depto. de Biología Molecular, Circuito Interior, Ciudad Universitaria, 04510 México, D.F.

Instituto de Investigaciones Biomédicas, UNAM, Depto. de Biología Molecular, Circuito Interior, Ciudad Universitaria, 04510 México, D.F.Search for more papers by this author

I. Sánchez,

I. Sánchez

Instituto de Investigaciones Biomédicas, UNAM, Depto. de Biología Molecular, Circuito Interior, Ciudad Universitaria, 04510 México, D.F.

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F. Gómez-Garibay,

F. Gómez-Garibay

Instituto de Química, UNAM. Circuito Exterior, Ciudad Universitaria, 04510 México, D.F.

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J. Taboada,

J. Taboada

Instituto de Investigaciones Biomédicas, UNAM, Depto. de Biología Molecular, Circuito Interior, Ciudad Universitaria, 04510 México, D.F.

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Dr B. H. Ruiz,

Corresponding Author

Dr B. H. Ruiz

Instituto de Investigaciones Biomédicas, UNAM, Depto. de Biología Molecular, Circuito Interior, Ciudad Universitaria, 04510 México, D.F.

Instituto de Investigaciones Biomédicas, UNAM, Depto. de Biología Molecular, Circuito Interior, Ciudad Universitaria, 04510 México, D.F.Search for more papers by this author

First published: 23 February 2000

https://doi.org/10.1002/(SICI)1099-1573(200003)14:2<89::AID-PTR569>3.0.CO;2-C

Citations: 101

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Abstract

In the present study we analysed the possible antiviral effect on dengue viruses of different flavonoids extracted and identified at the Chemistry Institute, UNAM, from the Mexican plants Tephrosia madrensis, Tephrosia viridiflora and Tephrosia crassifolia. The flavonoids glabranine and 7-O-methyl-glabranine presented 70% inhibition on the dengue virus at a concentration of 25 µM, while methyl-hildgardtol A, hildgardtol A and elongatine had no effect on viral growth.

Our results show that glabranine and 7-O-methyl-glabranine isolated from Tephrosia s.p. exert a dose-dependent inhibitory effect in vitro on the dengue virus. Copyright © 2000 John Wiley & Sons, Ltd.

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Volume14, Issue2

March 2000

Pages 89-92

Antiviral effect of flavonoids on the Dengue virus

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Antiviral effect of flavonoids on the Dengue virus

Abstract

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