Chromosome band 1q21 is recurrently gained in desmoid tumors
Marcelo L. Larramendy
Department of Medical Genetics, Haartman Institute, University of Helsinki, Helsinki, Finland
Laboratorio de Citogenética y Cátedra de Citología, Facultad de Ciencias Naturales, Universidad Nacional de La Plata, La Plata, Argentina
Search for more papers by this authorMartti Virolainen
Department of Pathology, Haartman Institute, University of Helsinki, Helsinki, Finland
Search for more papers by this authorErkki Tukiainen
Department of Plastic Surgery, Helsinki University Central Hospital, Helsinki, Finland
Search for more papers by this authorInkeri Elomaa
Department of Oncology, Helsinki University Central Hospital, Helsinki, Finland
Search for more papers by this authorCorresponding Author
Sakari Knuutila
Department of Medical Genetics, Haartman Institute, University of Helsinki, Helsinki, Finland
Laboratory of Medical Genetics, Helsinki University Central Hospital, Helsinki, Finland
Laboratory of Medical Genetics, Helsinki University Central Hospital, P.O. Box 404 (Haartmaninkatu 3, 4th flr), FIN-00029 HUCH, Helsinki, FinlandSearch for more papers by this authorMarcelo L. Larramendy
Department of Medical Genetics, Haartman Institute, University of Helsinki, Helsinki, Finland
Laboratorio de Citogenética y Cátedra de Citología, Facultad de Ciencias Naturales, Universidad Nacional de La Plata, La Plata, Argentina
Search for more papers by this authorMartti Virolainen
Department of Pathology, Haartman Institute, University of Helsinki, Helsinki, Finland
Search for more papers by this authorErkki Tukiainen
Department of Plastic Surgery, Helsinki University Central Hospital, Helsinki, Finland
Search for more papers by this authorInkeri Elomaa
Department of Oncology, Helsinki University Central Hospital, Helsinki, Finland
Search for more papers by this authorCorresponding Author
Sakari Knuutila
Department of Medical Genetics, Haartman Institute, University of Helsinki, Helsinki, Finland
Laboratory of Medical Genetics, Helsinki University Central Hospital, Helsinki, Finland
Laboratory of Medical Genetics, Helsinki University Central Hospital, P.O. Box 404 (Haartmaninkatu 3, 4th flr), FIN-00029 HUCH, Helsinki, FinlandSearch for more papers by this authorAbstract
DNA sequence copy number changes were studied by comparative genomic hybridization (CGH) in 28 desmoid tumors. Changes were detected in 12 tumors (43%) with a mean of 1.4 changes per sample (range: 1 to 7). Out of 12 tumors associated with pregnancy or Gardner's syndrome, only two displayed changes. The minimal common regions of the most frequent gains were 1q21 (39%), chromosome 20 (32%), and 9p12 (21%). No high-level amplifications were detected. Losses of DNA sequences were two times less frequent than gains and the minimal common regions of the most frequent losses were 6q16–q21 (14%), 5q14 (11%), and 13q21–q31 (11%). Genes Chromosomes Cancer 23:183–186, 1998. © 1998 Wiley-Liss, Inc.
References
- Armengol G, Tarkkanen M, Virolainen M, Valle J, Asko-Seljavaara S, Elomaa I, Karaharju E, Kivioja AH, Siimes MA, Tukiainen E, Caballin MR, Knuutila S (1997) Recurrent gains of 1q, 8, and 12 in the Ewing family of tumors by comparative genomic hybridization. Br J Cancer 75: 1403–1409.
- Baeg GH, Matsumine A, Kuroda T, Bhattacharjee RN, Miyashiro I, Yoyoshima K, Akimaya T (1995) The tumour suppressor gene product APC blocks cell cycle progression from G0/G1 to S-phase. EMBOJ 14: 5618–5624.
- Bodmer WF, Bailey CJ, Bodmer J, Bussey HJR, Ellis A, Gorman P, Lucibello FC, Murdya VA, Rider SH, Scambler P, Sheer D, Solomon E, Spurr NK (1987) Localization of the gene for familial adenomatous polyposis on chromosome 5. Nature 328: 614–616.
-
Bridge JA,
Sreekantaiah C,
Mouron B,
Neff JR,
Sandberg AA
(1992)
Clonal chromosomal abnormalities in desmoid tumors: Implications for histopathogenesis.
Cancer
69:
430–436.
10.1002/1097-0142(19920115)69:2<430::AID-CNCR2820690226>3.0.CO;2-H CAS PubMed Web of Science® Google Scholar
- Bridge JA, Meloni AM, Neff JR, Deboer J, Pickering D, Dalence C, Jeffrey B, Sandberg AA (1996) Deletion 5q in desmoid tumor and fluorescence in situ hybridization for chromosome 8 and/or 20 copy number. Cancer Genet Cytogenet 92: 150–151.
- Chang AE, Rosenberg SA, Glatstein EJ, Antman KH (1989) Desmoid tumors. In VT De Vita, S Hellman, SA Rosenberg (eds): Cancer Principles and Practice of Oncology. Philadelphia: Lippin-cott, pp 1353–1354.
- Clark SK, Phillips RK (1996) Desmoids in familial adenomatous polyposis. Br J Surg 83: 1494–1504.
- Dal Cin P, Sciot R, Aly MS, Delabie J, Stas M, De Wever I, Van Damme B, Van den Berghe H (1994) Some desmoid tumors are characterized by trisomy 8. Genes Chromosomes Cancer 10: 131–135.
- Dal Cin P, Sciot R, Van Damme B, De Wever I, Van den Berghe H (1995) Trisomy 20 characterizes a second group of desmoid tumors. Cancer Genet Cytogenet 79: 189.
- Dangel A, Meloni AM, Lynch HT, Sandberg AA (1994) Deletion (5q) in a desmoid tumor of a patient with Gardner's syndrome. Cancer Genet Cytogenet 78: 94–98.
- Eccles DM, van der Luijt R, Breukel C, Bullman H, Bunyan D, Fisher A, Barber J, du Boulay C, Primrose J, Burn J, Fodde R (1996) Hereditary desmoid disease due to a frameshift mutation at codon 1924 of the APC gene. Am J Hum Genet 59: 1193–1201.
- El-Rifai W, Larramendy ML, Björkqvist A-M, Hemmer S, Knuutila S (1997) Optimization of comparative genomic hybridization using fluorochrome conjugated to dCTP and dUTP nucleotides. Lab Invest 77: 699–700.
- Enzinger FM, Weiss SW (1995) Fibromatoses. In FM Enzinger, SW Weiss (eds): Soft Tissue Tumors. Saint Louis, MO: Mosby, pp 201–230.
- Fletcher JA, Naeem R, Xiao S, Corson JM (1995) Chromosome aberrations in desmoid tumors: Trisomy 8 may be a predictor of recurrence. Cancer Genet Cytogenet 79: 139–143.
- Forus A, Weterman MAJ, Geurts van Kessel AG, Berner J-M, Fodstad Ø, Myklebost O (1996) Characterization of 1q21–q22 amplicon in human sarcomas by CGH and molecular analysis. Cytogenet Cell Genet 72: 148.
- Heiskanen I, Järvinen HJ (1996) Occurrence of desmoid tumors in familial adenomatous polyposis and results of treatment. Int J Colorectal Dis 11: 157–162.
- Kallioniemi A, Kallioniemi O-P, Sudar D, Rutovitz D, Gray JW, Waldman F Pinkel D (1992) Comparative genomic hybridization for molecular cytogenetic analysis of solid tumors. Science 258: 818–821.
- Karlsson I, Mandahl N, Heim S, Rydholm A, Willén H, Mitelman F (1988) Complex chromosome rearrangements in an extraabdominal desmoid tumor. Cancer Genet Cytogenet 34: 241–245.
- Kinzler WK, Nilbert MC, Su L-K, Vogelstein B, Bryan TM, Levy DB, Smith KJ, Preisinger AC, Hedge P, McKechnie D, Finniear R, Markham A, Groffen J, Boguski MS, Altschul SF Horii A, Ando H, Miyoshi Y, Miki Y, Nishisho I, Nakamura Y (1991) Identification of FAP locus genes from chromosome 5q21. Science 253: 661–665.
- Knuutila S, Björkqvist A-M, Autio K, Tarkkanen M, Wolf M, Monni O, Szymanska J, Larramendy ML, Tapper J, Pere H, El-Rifai W, Hemmer S, Wasenius V-M, Vidgren V, Zhu Y (1998) DNA copy number amplifications in human neoplasms. Review of comparative genomic hybridization studies. Am J Pathol 152: 1107–1123.
- Larramendy ML, Tarkkanen M, Blomqvist C, Virolainen M, Wik-lund T, Asko-Seljavaara S, Elomaa I, Knuutila S (1997a) Comparative genomic hybridization of malignant fibrous histiocytoma reveals a novel prognostic marker. Am J Pathol 151: 1153–1161.
- Larramendy ML, Tarkkanen M, Valle J, Kivioja AH, Ervasti H, Karaharju E, Salmivalli T, Elomaa I, Knuutila S (1997b) Gains, losses, and amplifications of DNA sequences evaluated by comparative genomic hybridization in chondrosarcomas. Am J Pathol 150: 685–691.
- Mertens F, Willén H, Rydholm A, Brosjö O, Carlén B, Mitelman F, Mandahl N (1995) Trisomy 20 is a primary chromosome aberration in desmoid tumors. Int J Cancer 63: 527–529.
- Miller SA, Dykes DD, Polesky HF (1988) A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 16: 1215.
- Mitelman F (1994) Catalog of Chromosome Aberrations in Cancer, 5th ed. New York: John Wiley & Sons, Inc.
- Polakis P (1995) Mutations in the APC gene and their implications for protein structure and function. Curr Opin Genet Dev 5: 66–71.
- Qi H, Dal Cin P, Hernández JM, Garcia JL, Sciot R, Fletcher C, Van Eyken P, De Wever I, Van den Berghe H (1996) Trisomies 8 and 20 in desmoid tumors. Cancer Genet Cytogenet 92: 147–149.
-
Szymanska J,
Tarkkanen M,
Wiklund T,
Virolainen M,
Blomqvist C,
Asko-Seljavaara S,
Tukiainen E,
Elomaa I,
Knuutila S
(1996)
Gains and losses of DNA sequences in liposarcomas evaluated by comparative genomic hybridization.
Genes Chromosomes Cancer
15:
89–94.
10.1002/(SICI)1098-2264(199602)15:2<89::AID-GCC2>3.0.CO;2-# CAS PubMed Web of Science® Google Scholar
- Tarkkanen M, Karhu R, Kallioniemi A, Elomaa I, Kivioja AH, Nevalainen J, Böhling T, Karaharju E, Hyytinen E, Knuutila S, Kallioniemi O-P (1995) Gains and losses of DNA sequences in osteosarcomas by comparative genomic hybridization. Cancer Res 55: 1334–1338.
