Positive sharp wave and fibrillation potential modeling

A finite muscle fiber simulation program which calculates the extracellular potential for any given intracellular action potential (IAP) was used to model a fibrillation potential and a positive sharp wave. This computer model employs the core conductor model assumptions for an active muscle fiber and allows two distinct types of end effects: a cut or a crush. A “cut end” is defined as a membrane segment with the termination of both active and passive ion channels. The “crush end” is simulated as a focal membrane segment which blocks action potential propagation, and is connected to a region of normal membrane on either side of it so that a normal transmembrane potential is maintained beyond the crush zone. A prototypical positive sharp wave of appropriate amplitude and duration could only be detected extracellularly by using an IAP of the configuration found in denervated rat muscle recorded from a muscle fiber terminating in a crush segment of membrane. © 1999 John Wiley & Sons, Inc. Muscle Nerve 22: 242–251, 1999