Volume 21, Issue 4 pp. 547-549

Short Report

Muscle fiber type-specific myofibrillar actomyosin Ca²⁺ ATPase activity in multiple sclerosis

Michael J. Castro MS,

Michael J. Castro MS

Department of Exercise Science, 115F Ramsey Center, University of Georgia, 300 River Road, Athens, Georgia 30602, USA

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Jane A. Kent-Braun PhD,

Jane A. Kent-Braun PhD

Departments of Radiology and Neurology, University of California–San Francisco, San Francisco, California 94121, USA

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A.V. Ng PhD,

A.V. Ng PhD

Departments of Radiology and Neurology, University of California–San Francisco, San Francisco, California 94121, USA

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Robert G. Miller MD,

Robert G. Miller MD

Departments of Radiology and Neurology, University of California–San Francisco, San Francisco, California 94121, USA

Neurology Department, California Pacific Medical Center, San Francisco, California 94115, USA

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Gary A. Dudley PhD,

Corresponding Author

Gary A. Dudley PhD

Department of Exercise Science, 115F Ramsey Center, University of Georgia, 300 River Road, Athens, Georgia 30602, USA

Department of Exercise Science, 115F Ramsey Center, University of Georgia, 300 River Road, Athens, Georgia 30602, USASearch for more papers by this author

Michael J. Castro MS,

Michael J. Castro MS

Department of Exercise Science, 115F Ramsey Center, University of Georgia, 300 River Road, Athens, Georgia 30602, USA

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Jane A. Kent-Braun PhD,

Jane A. Kent-Braun PhD

Departments of Radiology and Neurology, University of California–San Francisco, San Francisco, California 94121, USA

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A.V. Ng PhD,

A.V. Ng PhD

Departments of Radiology and Neurology, University of California–San Francisco, San Francisco, California 94121, USA

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Robert G. Miller MD,

Robert G. Miller MD

Departments of Radiology and Neurology, University of California–San Francisco, San Francisco, California 94121, USA

Neurology Department, California Pacific Medical Center, San Francisco, California 94115, USA

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Gary A. Dudley PhD,

Corresponding Author

Gary A. Dudley PhD

Department of Exercise Science, 115F Ramsey Center, University of Georgia, 300 River Road, Athens, Georgia 30602, USA

Department of Exercise Science, 115F Ramsey Center, University of Georgia, 300 River Road, Athens, Georgia 30602, USASearch for more papers by this author

First published: 07 December 1998

https://doi.org/10.1002/(SICI)1097-4598(199804)21:4<547::AID-MUS18>3.0.CO;2-U

Citations: 13

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Abstract

Biopsies of tibialis anterior muscle were analyzed to determine if increased energy demand of contraction, as indirectly reflected by myofibrillar actomyosin Ca²⁺ ATPase (qATPase) activity, contributes to symptomatic fatigue in multiple sclerosis (MS). qATPase activity showed a fiber-type effect, IIax > IIa > I. Fiber-type qATPase activity, however, was not different between MS patients and healthy controls. We suggest that fatigue in MS does not reflect increased energy demand of contraction. © 1998 John Wiley & Sons, Inc. Muscle Nerve 21:547–549, 1998.

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Volume21, Issue4

April 1998

Pages 547-549

Muscle fiber type-specific myofibrillar actomyosin Ca²⁺ ATPase activity in multiple sclerosis

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Muscle fiber type-specific myofibrillar actomyosin Ca2+ ATPase activity in multiple sclerosis

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Muscle fiber type-specific myofibrillar actomyosin Ca²⁺ ATPase activity in multiple sclerosis