Transcutaneous access to retrograde axonal flow
Paul D. Costas MD
Department of Plastic and Reconstructive Surgery, Plastic Surgery Research Laboratory, Lahey Hitchcock Medical Center, 41 Mall Road, Burlington, Massachusetts 01805, USA
Search for more papers by this authorThomas D. Sabin MD
Department of Plastic and Reconstructive Surgery, Plastic Surgery Research Laboratory, Lahey Hitchcock Medical Center, 41 Mall Road, Burlington, Massachusetts 01805, USA
Search for more papers by this authorKai-Kai Wang MD
Department of Plastic and Reconstructive Surgery, Plastic Surgery Research Laboratory, Lahey Hitchcock Medical Center, 41 Mall Road, Burlington, Massachusetts 01805, USA
Search for more papers by this authorDavid S. Jones
Department of Plastic and Reconstructive Surgery, Plastic Surgery Research Laboratory, Lahey Hitchcock Medical Center, 41 Mall Road, Burlington, Massachusetts 01805, USA
Search for more papers by this authorCorresponding Author
Brooke R. Seckel MD
Department of Plastic and Reconstructive Surgery, Plastic Surgery Research Laboratory, Lahey Hitchcock Medical Center, 41 Mall Road, Burlington, Massachusetts 01805, USA
Department of Plastic and Reconstructive Surgery, Plastic Surgery Research Laboratory, Lahey Hitchcock Medical Center, 41 Mall Road, Burlington, Massachusetts 01805, USASearch for more papers by this authorPaul D. Costas MD
Department of Plastic and Reconstructive Surgery, Plastic Surgery Research Laboratory, Lahey Hitchcock Medical Center, 41 Mall Road, Burlington, Massachusetts 01805, USA
Search for more papers by this authorThomas D. Sabin MD
Department of Plastic and Reconstructive Surgery, Plastic Surgery Research Laboratory, Lahey Hitchcock Medical Center, 41 Mall Road, Burlington, Massachusetts 01805, USA
Search for more papers by this authorKai-Kai Wang MD
Department of Plastic and Reconstructive Surgery, Plastic Surgery Research Laboratory, Lahey Hitchcock Medical Center, 41 Mall Road, Burlington, Massachusetts 01805, USA
Search for more papers by this authorDavid S. Jones
Department of Plastic and Reconstructive Surgery, Plastic Surgery Research Laboratory, Lahey Hitchcock Medical Center, 41 Mall Road, Burlington, Massachusetts 01805, USA
Search for more papers by this authorCorresponding Author
Brooke R. Seckel MD
Department of Plastic and Reconstructive Surgery, Plastic Surgery Research Laboratory, Lahey Hitchcock Medical Center, 41 Mall Road, Burlington, Massachusetts 01805, USA
Department of Plastic and Reconstructive Surgery, Plastic Surgery Research Laboratory, Lahey Hitchcock Medical Center, 41 Mall Road, Burlington, Massachusetts 01805, USASearch for more papers by this authorAbstract
Transcutaneous entry of fluorescent tracer and subsequent retrograde neuronal transport achieved by the use of dimethyl sulfoxide (DMSO) as a vehicle fluorescent dye dissolved in DMSO and applied topically to the hind limb of rats was found in corresponding dorsal root ganglia; aqueous absorption of tracer dye by neuronal tissue was not demonstrated. This example of transcutaneous access and retrograde transport may have implications as to the entry of various toxins, viruses, chemicals, and therapeutic agents to the nervous system. © 1998 John Wiley & Sons, Inc. Muscle Nerve 21:531–532, 1998.
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