Volume 20, Issue 10 pp. 1324-1327
Short Report

A case of Isaacs' syndrome with associated central nervous system findings

J. Ansell MD

J. Ansell MD

Queen Elizabeth II Health Sciences Centre, Neurological Investigation Unit, Division of Neurology, Dalhousie University, Halifax, Nova Scotia B3H 2Y9, Canada

Search for more papers by this author
S. Kirby MD, FRCP(C)

S. Kirby MD, FRCP(C)

Queen Elizabeth II Health Sciences Centre, Neurological Investigation Unit, Division of Neurology, Dalhousie University, Halifax, Nova Scotia B3H 2Y9, Canada

Search for more papers by this author
T. Benstead MD, FRCP(C)

Corresponding Author

T. Benstead MD, FRCP(C)

Queen Elizabeth II Health Sciences Centre, Neurological Investigation Unit, Division of Neurology, Dalhousie University, Halifax, Nova Scotia B3H 2Y9, Canada

Queen Elizabeth II Health Sciences Centre, Neurological Investigation Unit, Division of Neurology, Dalhousie University, Halifax, Nova Scotia B3H 2Y9, CanadaSearch for more papers by this author

Abstract

We report a 44-year-old female with Isaacs' syndrome, peripheral motor neuropathy, and features of central pontine myelinolysis (CPM). The patient presented with stiffness and muscle spasms accompanied by profound sweating. She also had bilateral Babinski signs. Electrodiagnostic abnormalities were characteristic of Isaacs' syndrome. Magnetic resonance imaging demonstrated features of CPM. She gained modest relief from baclofen, valproate, and diazepam. She improved dramatically following plasmapheresis and continued to recover on prednisone. She was weaned from steroids without relapse. © 1997 John Wiley & Sons, Inc. Muscle Nerve 20: 1324–1327, 1997

The full text of this article hosted at iucr.org is unavailable due to technical difficulties.

click me