Genetic regulation of slowly progressing mild muscle atrophy in fast-twitch muscles of BUF/Mna rats
Mitsuhiro Saito BSc
Department of Pathology, Nagoya University School of Medicine, Nagoya, Japan
Search for more papers by this authorShizuko Nagao PhD
Laboratory Animal Center, Fujita Health University School of Medicine, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake-shi, Aichi-ken 470-11, Japan
Search for more papers by this authorShigeru Yagiu PhD
Laboratory Animal Center, Fujita Health University School of Medicine, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake-shi, Aichi-ken 470-11, Japan
Search for more papers by this authorHisahide Takahashi PhD
Laboratory Animal Center, Fujita Health University School of Medicine, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake-shi, Aichi-ken 470-11, Japan
Search for more papers by this authorHiroyuki Morita MD
Branch Hospital, Nagoya University School of Medicine, Nagoya, Japan
Search for more papers by this authorTakako Matsuyama Morita MD
Second Department of Surgery, Nagoya University School of Medicine, Nagoya, Japan
Search for more papers by this authorCorresponding Author
Mutsushi Matsuyama MD
Department of Pathology, Fujita Health University School of Medicine, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake-shi, Aichi-ken 470-11, Japan
Department of Pathology, Fujita Health University School of Medicine, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake-shi, Aichi-ken 470-11, JapanSearch for more papers by this authorMitsuhiro Saito BSc
Department of Pathology, Nagoya University School of Medicine, Nagoya, Japan
Search for more papers by this authorShizuko Nagao PhD
Laboratory Animal Center, Fujita Health University School of Medicine, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake-shi, Aichi-ken 470-11, Japan
Search for more papers by this authorShigeru Yagiu PhD
Laboratory Animal Center, Fujita Health University School of Medicine, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake-shi, Aichi-ken 470-11, Japan
Search for more papers by this authorHisahide Takahashi PhD
Laboratory Animal Center, Fujita Health University School of Medicine, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake-shi, Aichi-ken 470-11, Japan
Search for more papers by this authorHiroyuki Morita MD
Branch Hospital, Nagoya University School of Medicine, Nagoya, Japan
Search for more papers by this authorTakako Matsuyama Morita MD
Second Department of Surgery, Nagoya University School of Medicine, Nagoya, Japan
Search for more papers by this authorCorresponding Author
Mutsushi Matsuyama MD
Department of Pathology, Fujita Health University School of Medicine, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake-shi, Aichi-ken 470-11, Japan
Department of Pathology, Fujita Health University School of Medicine, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake-shi, Aichi-ken 470-11, JapanSearch for more papers by this authorAbstract
BUF/Mna strain rats spontaneously develop slowly progressing mild-moderate muscle atrophy of extensor digitorum longus, tibialis, and extraocular muscles, which consist mainly of fast-twitch type fibers, at nearly 100% incidence. They have lighter extensor digitorum longus muscles than soleus muscles, when alive for more than 6 weeks. Genetic segregation of the development of the muscle atrophy was studied by crossing the BUF/Mna strain with three other strains, ACI/NMs, WKY/NCrj, and BDIX, which were free of muscle atrophy. Two autosomal dominant susceptible genes, Mas-1 and Mas-2, determine the development of the muscle atrophy in these combinations of crosses. © 1997 John Wiley & Sons, Inc. Muscle Nerve 20: 1258–1263, 1997
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